Pou5f1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pou5f1
POU domain, class 5, transcription factor 1
MGI:101893

22 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Atg5^tm1.1Myok/Atg5^tm1.1Myok Col1a1^{tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae}/Col1a1⁺ involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N	abnormal cell physiology	J:205532
Col1a1^{tm2(tetO-Pou5f1)Jae}/Col1a1⁺ Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}/Gt(ROSA)26Sor⁺ involves: 129S4/SvJae C57BL/6	abnormal cell proliferation	J:98920
	abnormal epidermal layer morphology	J:98920
	abnormal forestomach morphology	J:98920
	abnormal hair follicle morphology	J:98920
	abnormal intermediate gastric gland morphology	J:98920
	abnormal intestinal epithelium morphology	J:98920
	abnormal small intestine morphology	J:98920
	abnormal stomach epithelium morphology	J:98920
	abnormal stomach glandular epithelium morphology	J:98920
	abnormal stomach mucosa morphology	J:98920
	dehydration	J:98920
	increased skin tumor incidence	J:98920
	lethargy	J:98920
	premature death	J:98920
	spleen atrophy	J:98920
	stomach epithelial hyperplasia	J:98920
	thymus atrophy	J:98920
Col1a1^{tm2(tetO-Pou5f1)Jae}/Col1a1⁺ Gt(ROSA)26Sor^tm1(tTA)Roos/Gt(ROSA)26Sor⁺ Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J	abnormal intestine physiology	J:199754
	abnormal small intestine crypts of Lieberkuhn morphology	J:199754
	increased cell proliferation	J:199754
Col1a1^{tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae}/Col1a1^{tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae} Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}/Gt(ROSA)26Sor^{tm1(rtTAM2)Jae} involves: 129S4/SvJae * C57BL/6	no abnormal phenotype detected	J:157298
Hdac2^tm1.1Eem/Hdac2^tm1.1Eem Pou5f1^tm2Jae/? involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	abnormal cell physiology	J:171358
Mir34a^tm1.1Lhe/Mir34a^tm1.1Lhe Pou5f1^tm2Jae/Pou5f1⁺ involves: 129S4/SvJae * C57BL/6 * C57BL/6J	abnormal cell physiology	J:180692

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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