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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Mmp14
matrix metallopeptidase 14 (membrane-inserted)
MGI:101900
121 phenotypes from 7 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Mmp14m1Btlr/Mmp14m1Btlr
C57BL/6J-Mmp14m1Btlr
abnormal postnatal growth/weight/body size J:133626
decreased body weight J:133626
decreased cranium height J:133626
infertility J:133626
macrophthalmia J:133626
premature death J:133626
prenatal lethality, incomplete penetrance J:133626
short snout J:133626
Mmp14sabe/Mmp14sabe
B6(129P2)-Mmp14sabe/GrsrJ
abnormal gait J:127164
decreased body size J:127164
decreased cranium height J:127164
decreased cranium width J:127164
domed cranium J:127164
enlarged optic nerve J:127164
exophthalmos J:127164
increased or absent threshold for auditory brainstem response J:127164
increased percent body fat/body weight J:127164
premature death J:127164
round head J:127164
short mandible J:127164
short maxilla J:127164
small ears J:127164
normal vision/eye phenotype J:127164
Mmp14tm1Hbh/Mmp14tm1Hbh
involves: 129P1/ReJ * 129P2/OlaHsd * Black Swiss
abnormal club cell morphology J:97067
abnormal pulmonary alveolus morphology J:97067
abnormal pulmonary elastic fiber morphology J:97067
abnormal terminal bronchiole morphology J:97067
absent alveolar pores J:97067
dilated pulmonary alveolar duct J:97067
dilated respiratory conducting tube J:97067
impaired lung alveolus development J:97067
overexpanded pulmonary alveolus J:97067
pulmonary hypoplasia J:97067
Mmp14tm1Hbh/Mmp14tm1Hbh
involves: 129P2/OlaHsd
abnormal chondrocyte morphology J:130212
decreased cranium length J:130212
short humerus J:130212
Mmp14tm1Hbh/Mmp14tm1Hbh
involves: 129P2/OlaHsd * Black Swiss
abnormal bone ossification J:57969
abnormal bone remodeling J:86538
abnormal cartilage development J:86538
abnormal cartilage morphology J:57969
abnormal chondrocyte morphology J:57969, J:86538
abnormal cranial suture morphology J:57969
abnormal cranium morphology J:57969
abnormal fontanelle morphology J:57969
abnormal forelimb morphology J:57969
abnormal interparietal bone morphology J:57969
abnormal joint morphology J:86538
abnormal long bone epiphyseal plate morphology J:57969
abnormal long bone morphology J:57969
abnormal Meckel's cartilage morphology J:86538
abnormal neurocranium morphology J:57969
abnormal orbit morphology J:57969
abnormal osteoclast physiology J:57969, J:86538
abnormal parietal bone morphology J:57969, J:86538
abnormal skeleton development J:57969, J:198679
abnormal skeleton physiology J:57969
abnormal trabecular bone morphology J:57969
absent sexual maturation J:57969
autoimmune arthritis J:57969
cachexia J:57969
decreased body size J:57969
decreased body weight J:57969
decreased bone mineral density J:57969
decreased length of long bones J:57969
decreased locomotor activity J:57969
delayed bone ossification J:57969
disproportionate dwarf J:57969
domed cranium J:57969
focal hair loss J:57969
impaired osteoblast differentiation J:198679
kyphosis J:57969
lordosis J:57969
osteoporosis J:57969
postnatal lethality, incomplete penetrance J:57969
premature death J:57969
short snout J:57969
skeletal muscle fibrosis J:57969
skin fibrosis J:57969
Mmp14tm1Ktry/Mmp14tm1Ktry
B6.129X1-Mmp14tm1Ktry
abnormal axial skeleton morphology J:61685
abnormal bone mineralization J:61685
abnormal bone ossification J:61685
abnormal cartilage development J:61685
abnormal cranial suture morphology J:61685
abnormal cranial vertex morphology J:61685
abnormal craniofacial morphology J:61685
abnormal cranium morphology J:61685
abnormal long bone epiphyseal plate proliferative zone J:61685
abnormal neurocranium morphology J:61685
abnormal upper incisor morphology J:61685
cachexia J:61685
decreased angiogenesis J:61685
decreased body weight J:61685
decreased locomotor activity J:61685
delayed endochondral bone ossification J:61685
domed cranium J:61685
increased width of hypertrophic chondrocyte zone J:61685
lethality at weaning, complete penetrance J:61685
loose skin J:61685
malocclusion J:61685
short incisors J:61685
short limbs J:61685
short lower incisors J:61685
short mandible J:61685
short maxilla J:61685
short snout J:61685
short upper incisors J:61685
small cranial cavity J:61685
Mmp14tm1Ktry/Mmp14tm1Ktry
involves: 129X1/SvJ
abnormal dendritic cell physiology J:138782
abnormal incisor morphology J:103089
abnormal tooth development J:103089
delayed tooth eruption J:103089
small mandible J:103089
Mmp14tm1Ktry/Mmp14tm1Ktry
involves: 129X1/SvJ * C57BL/6
abnormal bronchiole morphology J:95881
abnormal lung morphology J:95881
abnormal pulmonary alveolus morphology J:95881
abnormal submandibular gland branching morphogenesis J:95881
decreased submandibular gland size J:95881
overexpanded pulmonary alveolus J:95881
postnatal lethality, complete penetrance J:95881
small lung J:95881
Mmp14tm1Noda/Mmp14tm1Noda
Not Specified
no abnormal phenotype detected J:91198
Mmp14tm1Ski/Mmp14tm1Ski
B6.Cg-Mmp14tm1Ski
abnormal basement membrane morphology J:165029
abnormal joint morphology J:113113
abnormal kidney corticomedullary boundary morphology J:165029
abnormal kidney development J:165029
abnormal kidney morphology J:165029
abnormal kidney papilla morphology J:165029
abnormal skeletal muscle fiber morphology J:113113, J:165029
abnormal skeleton physiology J:113113
centrally nucleated skeletal muscle fibers J:113113
decreased body size J:165029
decreased kidney cell proliferation J:165029
decreased renal glomerulus number J:165029
impaired branching involved in ureteric bud morphogenesis J:165029
increased skeletal muscle fiber size J:113113
kidney cortex hypoplasia J:165029
postnatal lethality J:165029
premature death J:113113
skeletal muscle interstitial fibrosis J:113113
small kidney J:165029
Mmp14tm1Stjw/Mmp14tm1Stjw
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: C57BL/6 * CD-1
normal adipose tissue phenotype J:198679
decreased bone mineral density J:198679
delayed cranial suture closure J:198679
delayed intramembranous bone ossification J:198679
normal skeleton phenotype J:198679
Mmp14tm1Stjw/Mmp14tm1Stjw
Twist2tm1.1(cre)Dor/Twist2+
involves: 129X1/SvJ * C57BL/6
abnormal bone ossification J:198679
abnormal cartilage morphology J:198679
abnormal hypodermis fat layer morphology J:198679
abnormal joint morphology J:198679
decreased body size J:198679
decreased body weight J:198679
decreased bone mineral density J:198679
delayed cranial suture closure J:198679
delayed intramembranous bone ossification J:198679
domed cranium J:198679
increased bone marrow adipose tissue amount J:198679
postnatal growth retardation J:198679
premature death J:198679
short snout J:198679
normal skeleton phenotype J:198679

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory