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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cpe
carboxypeptidase E
MGI:101932
68 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cpefat/Cpefat
BKSChpLt.HRS-Cpefat/J 		abnormal hormone level J:80698
abnormal hypothalamus secretion J:80698
abnormal pancreatic beta cell morphology J:24436
abnormal percent body fat/body weight J:10872
decreased circulating adrenocorticotropin level J:40372
decreased circulating gastrin level J:52393
decreased digestive secretion J:52393
degranulated pancreatic beta cells J:10872
hyperglycemia J:10872
impaired adaptive thermogenesis J:80698
increased circulating cholesterol level J:18161, J:19043
increased circulating growth hormone level J:40372
increased circulating HDL cholesterol level J:18161, J:19043
increased circulating insulin level J:10872, J:24436
increased circulating LDL cholesterol level J:19043
increased circulating pituitary hormone level J:38227, J:40372
increased circulating triglyceride level J:19043
increased circulating triiodothyronine level J:80698
increased circulating VLDL cholesterol level J:19043
increased growth hormone level J:40372
increased pituitary hormone level J:40372
infertility J:10872
obese J:10872
pancreatic islet hyperplasia J:10872
Cpefat/Cpefat
involves: HRS/J 		abnormal pancreatic beta cell morphology J:10872
degranulated pancreatic beta cells J:13651
hyperglycemia J:10872
hypoglycemia J:13651
increased circulating insulin level J:10872, J:13651
increased pancreatic islet number J:13651
increased total body fat amount J:10872
infertility J:10872
obese J:10872, J:13651
pancreatic islet hyperplasia J:10872
Cpetm1b(EUCOMM)Hmgu/Cpetm1b(EUCOMM)Hmgu
C57BL/6N-Cpetm1b(EUCOMM)Hmgu/Ieg 		abnormal behavior J:211773
abnormal locomotor behavior J:211773
aorta stenosis J:211773
decreased body length J:211773
decreased circulating chloride level J:211773
decreased exploration in new environment J:211773
decreased food intake J:211773
decreased grip strength J:211773
decreased locomotor activity J:211773
decreased vertical activity J:211773
hyperactivity J:211773
impaired glucose tolerance J:211773
increased circulating alanine transaminase level J:211773
increased circulating alkaline phosphatase level J:211773
increased circulating aspartate transaminase level J:211773
increased circulating calcium level J:211773
increased circulating glucose level J:211773
increased fasting circulating glucose level J:211773
increased hematocrit J:211773
increased leukocyte cell number J:211773
increased mean corpuscular volume J:211773
increased startle reflex J:211773
increased thigmotaxis J:211773
male infertility J:211773
Cpetm1Yplo/Cpetm1Yplo
involves: 129S1/Sv * C57BL/6 		abnormal energy expenditure J:95741
abnormal gait J:95741
abnormal glucose homeostasis J:95741
abnormal hypothalamus secretion J:95741
abnormal motor capabilities/coordination/movement J:95741
abnormal motor coordination/balance J:95741
abnormal muscle physiology J:95741
abnormal physical strength J:95741
abnormal placing response J:95741
decreased grip strength J:95741
decreased locomotor activity J:95741
decreased vertical activity J:95741
hyporesponsive to tactile stimuli J:95741
impaired glucose tolerance J:95741
increased body length J:95741
increased circulating glucose level J:95741
increased circulating insulin level J:95741
increased circulating leptin level J:95741
increased respiratory quotient J:95741
increased total body fat amount J:95741
insulin resistance J:95741
lethargy J:95741
obese J:95741
polyphagia J:95741
reduced fertility J:95741
tremors J:95741
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory