Mlh1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mlh1
mutL homolog 1
MGI:101938

41 phenotypes from 8 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mlh1^m1Btlr/Mlh1^m1Btlr C57BL/6J-Mlh1^m1Btlr	abnormal humoral immune response	J:265206
Mlh1^m1Btlr/Mlh1^m1Btlr C57BL/6J-Mlh1^m1Btlr	increased IgM level	J:265206
Mlh1^m2Btlr/Mlh1^m2Btlr C57BL/6J-Mlh1^m2Btlr	abnormal humoral immune response	J:265207
	decreased IgE level	J:265207
	increased IgM level	J:265207
Mlh1^m3Btlr/Mlh1^m3Btlr C57BL/6J-Mlh1^m3Btlr	abnormal humoral immune response	J:265208
	decreased IgE level	J:265208
	increased IgM level	J:265208
Mlh1^{tm1b(EUCOMM)Hmgu}/Mlh1^{tm1b(EUCOMM)Hmgu} C57BL/6N-Mlh1^{tm1b(EUCOMM)Hmgu}/H	cataract	J:211773
	increased circulating alanine transaminase level	J:211773
	increased circulating aspartate transaminase level	J:211773
	increased spleen weight	J:211773
	male infertility	J:211773
	small testis	J:211773
Mlh1^tm1Lisk/Mlh1^tm1Lisk involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	increased intestinal adenocarcinoma incidence	J:75745
	increased intestinal adenoma incidence	J:75745
	increased lymphoma incidence	J:75745
	increased skin tumor incidence	J:75745
	increased uterus tumor incidence	J:75745
	premature death	J:75745
	preweaning lethality, incomplete penetrance	J:75745
Mlh1^tm1Lisk/Mlh1^tm1Lisk involves: 129S7/SvEvBrd	abnormal ovarian folliculogenesis	J:34291
	arrest of male meiosis	J:34291
	azoospermia	J:34291
	decreased corpora lutea number	J:34291
	female infertility	J:34291
	increased lymphoma incidence	J:34291
	male infertility	J:34291
	small ovary	J:34291
Mlh1^tm1Lisk/Mlh1^tm1Lisk involves: 129S7/SvEvBrd * C57BL/6	abnormal chiasmata formation	J:216866
Mlh1^tm1Mse/Mlh1^tm1Mse involves: 129S/SvEv	increased T cell derived lymphoma incidence	J:47642
Mlh1^tm1Mse/Mlh1^tm1Mse involves: 129S/SvEv	increased tumor incidence	J:47642
Mlh1^tm1Rak/Mlh1⁺ involves: 129P2/OlaHsd * C57BL/6	increased adenocarcinoma incidence	J:53451
	increased carcinoma incidence	J:53451
	increased gastrointestinal tumor incidence	J:53451
	increased lung carcinoma incidence	J:53451
	increased lymphoma incidence	J:53451
	increased squamous cell carcinoma incidence	J:53451
	increased T cell derived lymphoma incidence	J:53451
	increased tumor incidence	J:53451
	premature death	J:53451
Mlh1^tm1Rak/Mlh1^tm1Rak involves: 129P2/OlaHsd	decreased physiological sensitivity to xenobiotic	J:133352
	decreased sensitivity to induced cell death	J:133352
	increased gastrointestinal tumor incidence	J:133352
	increased lymphoma incidence	J:133352
	increased skin tumor incidence	J:133352
	increased small intestine adenocarcinoma incidence	J:133352
	premature death	J:133352
Mlh1^tm1Rak/Mlh1^tm1Rak involves: 129P2/OlaHsd * C57BL/6	abnormal apoptosis	J:33878
	abnormal female meiosis	J:33878
	arrest of male meiosis	J:33878
	azoospermia	J:33878
	female infertility	J:33878
	increased adenoma incidence	J:53451
	increased B cell derived lymphoma incidence	J:53451, J:98929
	increased carcinoma incidence	J:53451
	increased gastrointestinal tumor incidence	J:53451
	increased lymphoma incidence	J:53451
	increased T cell derived lymphoma incidence	J:53451
	increased tumor incidence	J:53451
	male infertility	J:33878
	premature death	J:53451, J:98929
	small testis	J:33878
Mlh1^tm1Rak/Mlh1^tm1Rak involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	increased intestinal adenocarcinoma incidence	J:153684
	increased intestinal adenoma incidence	J:153684
	increased lymphoma incidence	J:153684
	increased T cell derived lymphoma incidence	J:153684
	premature death	J:153684
Mlh1^tm1Wed/Mlh1^tm1Wed involves: 129/Sv * C57BL/6J * SJL	abnormal male meiosis	J:133352
	abnormal meiotic spindle morphology	J:133352
	arrest of male meiosis	J:133352
	female infertility	J:133352
	increased basal cell carcinoma incidence	J:133352
	increased lymphoma incidence	J:133352
	increased tumor incidence	J:133352
	male infertility	J:133352
	oligozoospermia	J:133352
	premature death	J:133352

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