Mlh1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mlh1
mutL homolog 1
MGI:101938

19 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apc^tm1Rak/Apc⁺ Mlh1^tm1Rak/Mlh1⁺ involves: 129P2/OlaHsd * C57BL/6	increased gastrointestinal tumor incidence	J:53451
	increased tumor incidence	J:53451
	premature death	J:53451
Apc^tm1Rak/Apc⁺ Mlh1^tm1Rak/Mlh1^tm1Rak involves: 129P2/OlaHsd * C57BL/6	increased adenocarcinoma incidence	J:53451
	increased adenoma incidence	J:53451
	increased carcinoma incidence	J:53451
	increased gastrointestinal tumor incidence	J:53451
	increased lymphoma incidence	J:53451
	increased skin tumor incidence	J:53451
	increased tumor incidence	J:53451
	melena	J:53451
	premature death	J:53451
Dnmt1^tm1Jae/Dnmt1⁺ Mlh1^tm1Lisk/Mlh1^tm1Lisk involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	increased intestinal adenocarcinoma incidence	J:75745
	increased intestinal adenoma incidence	J:75745
	increased lymphoma incidence	J:75745
	premature death	J:75745
Dnmt1^tm1Jae/Dnmt1^tm1Pwl Mlh1^tm1Lisk/Mlh1^tm1Lisk involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	increased lymphoma incidence	J:75745
	normal neoplasm	J:75745
	premature death	J:75745
Dnmt1^tm1Pwl/Dnmt1⁺ Mlh1^tm1Lisk/Mlh1^tm1Lisk involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	increased intestinal adenocarcinoma incidence	J:75745
	increased intestinal adenoma incidence	J:75745
	increased lymphoma incidence	J:75745
	premature death	J:75745
Fan1^em1Mem/Fan1^em1Mem Htt^tm5Mem/Htt⁺ Mlh1^tm1Rak/Mlh1^tm1Rak involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J	normal cellular phenotype	J:298297
Meikin^tm1Yow/Meikin^tm1Yow Mlh1^tm1Lisk/Mlh1^tm1Lisk involves: 129S7/SvEvBrd * C57BL/6	abnormal chromosomal synapsis	J:216866
Mgmt^tm1Mse/Mgmt^tm1Mse Mlh1^tm1Mse/Mlh1^tm1Mse involves: 129S/SvEv	normal homeostasis/metabolism phenotype	J:47642
	increased lung adenoma incidence	J:47642
	increased T cell derived lymphoma incidence	J:47642
Mlh1^tm1Rak/Mlh1^tm1Rak Pold1^tm1.1Bdp/Pold1^tm1.1Bdp involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J	embryonic lethality during organogenesis, complete penetrance	J:153684
Mlh1^tm1Rak/Mlh1^tm1Rak Pole^tm1.1Bdp/Pole^tm1.1Bdp involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J	lethality during fetal growth through weaning, complete penetrance	J:153684

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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