Hmgcs2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hmgcs2
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
MGI:101939

17 phenotypes from 3 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hmgcs2^em1(IMPC)Tcp/Hmgcs2⁺ C57BL/6NCrl-Hmgcs2^em1(IMPC)Tcp	abnormal circulating ketone body level	J:326918
	increased liver weight	J:326918
	increased susceptibility to weight gain	J:326918
	microvesicular hepatic steatosis	J:326918
Hmgcs2^em1(IMPC)Tcp/Hmgcs2^em1(IMPC)Tcp C57BL/6NCrl-Hmgcs2^em1(IMPC)Tcp	decreased body weight	J:326918
	decreased circulating ketone body level	J:326918
	decreased lean body mass	J:326918
	enlarged liver	J:326918
	hepatic steatosis	J:326918
	increased body fat mass	J:326918
	increased liver triglyceride level	J:326918
	increased liver weight	J:326918
	lethargy	J:326918
	microvesicular hepatic steatosis	J:326918
	pale liver	J:326918
	postnatal lethality, incomplete penetrance	J:326918
	slow postnatal weight gain	J:326918
Hmgcs2^em1Wilh/Hmgcs2^em1Wilh involves: C57BL/6	normal reproductive system phenotype	J:285178
Hmgcs2^em2Wilh/Hmgcs2^em2Wilh involves: C57BL/6	reproductive system phenotype	J:285178

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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