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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Hmgcs2
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
MGI:101939
28 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Hmgcs2em1(IMPC)Tcp/Hmgcs2+
C57BL/6NCrl-Hmgcs2em1(IMPC)Tcp
abnormal circulating ketone body level J:326918
increased liver weight J:326918
increased susceptibility to weight gain J:326918
microvesicular hepatic steatosis J:326918
Hmgcs2em1(IMPC)Tcp/Hmgcs2em1(IMPC)Tcp
C57BL/6NCrl-Hmgcs2em1(IMPC)Tcp
decreased body weight J:326918
decreased circulating ketone body level J:326918
decreased lean body mass J:326918
enlarged liver J:326918
hepatic steatosis J:326918
increased body fat mass J:326918
increased liver triglyceride level J:326918
increased liver weight J:326918
lethargy J:326918
microvesicular hepatic steatosis J:326918
pale liver J:326918
postnatal lethality, incomplete penetrance J:326918
slow postnatal weight gain J:326918
Hmgcs2em1Wilh/Hmgcs2em1Wilh
involves: C57BL/6
normal reproductive system phenotype J:285178
Hmgcs2em2Wilh/Hmgcs2em2Wilh
involves: C57BL/6
reproductive system phenotype J:285178
Hmgcs2tm1.1Yil/Hmgcs2tm1.1Yil
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * C3H * C57BL/6 * C57BL/6J
abnormal intestinal crypt stem cell physiology J:280699
abnormal small intestine crypts of Lieberkuhn morphology J:280699
decreased intestinal crypt stem cell number J:280699
Hmgcs2tm1.1Yil/Hmgcs2tm1.1Yil
Tg(Vil1-cre/ERT2)23Syr/0
involves: C3H * C57BL/6 * C57BL/6J * DBA/2
abnormal homeostasis J:280699
abnormal jejunal goblet cell morphology J:280699
abnormal jejunum crypts of Lieberkuhn morphology J:280699
decreased body weight J:280699
decreased intestinal crypt stem cell number J:280699
decreased survivor rate J:280699
enhanced intestine regeneration J:280699
increased Paneth cell number J:280699
premature death J:280699
Hmgcs2tm1Yil/Hmgcs2+
Not Specified
no abnormal phenotype detected J:280699

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory