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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		E2f1
E2F transcription factor 1
MGI:101941
269 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Abcc6tm1c(EUCOMM)Wtsi/Abcc6tm1c(EUCOMM)Wtsi
E2f1Tg(Wnt1-cre)2Sor/?
B6.Cg-E2f1Tg(Wnt1-cre)2Sor Abcc6tm1c(EUCOMM)Wtsi 		abnormal snout skin morphology J:252837
calcified skin J:252837
calcinosis J:252837
Abcc6tm1c(EUCOMM)Wtsi/Abcc6tm1c(EUCOMM)Wtsi
E2f1Tg(Wnt1-cre)2Sor/?
Speer6-ps1Tg(Alb-cre)21Mgn/?
B6.Cg-E2f1Tg(Wnt1-cre)2Sor Abcc6tm1c(EUCOMM)Wtsi Speer6-ps1Tg(Alb-cre)21Mgn 		abnormal snout skin morphology J:252837
calcified skin J:252837
calcinosis J:252837
Ankrd11tm1c(EUCOMM)Wtsi/Ankrd11+
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: C3H * C57BL/6 * C57BL/6N 		abnormal frontal bone morphology J:306391
abnormal mandible morphology J:306391
abnormal midface morphology J:306391
abnormal neurocranium morphology J:306391
abnormal nose morphology J:306391
abnormal pterygoid bone morphology J:306391
enlarged neurocranium J:306391
large anterior fontanelle J:306391
midface hypoplasia J:306391
normal mortality/aging J:306391
narrow face J:306391
wide metopic suture J:306391
Ankrd11tm1c(EUCOMM)Wtsi/Ankrd11tm1c(EUCOMM)Wtsi
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: C3H * C57BL/6 * C57BL/6N 		abnormal basicranium morphology J:306391
abnormal bone collagen fibril morphology J:306391
abnormal bone remodeling J:306391
abnormal cranial blood vasculature morphology J:306391
abnormal craniofacial morphology J:306391
abnormal head morphology J:306391
abnormal intramembranous bone ossification J:306391
abnormal neurocranium morphology J:306391
abnormal osteocyte morphology J:306391
abnormal palatal mesenchymal cell proliferation J:306391
abnormal palatal shelf morphology J:306391
abnormal palatine bone morphology J:306391
abnormal snout skin morphology J:306391
absent pterygoid process J:306391
cleft hard palate J:306391
cleft palate J:306391
decreased bone ossification J:306391
decreased bone resorption J:306391
decreased bone trabecula number J:306391
decreased osteoclast cell number J:306391
decreased tongue size J:306391
delayed intramembranous bone ossification J:306391
domed cranium J:306391
eyelids open at birth J:306391
frontal bone hypoplasia J:306391
hypopigmentation J:306391
impaired ossification of basisphenoid bone J:306391
large anterior fontanelle J:306391
micrognathia J:306391
midface hypoplasia J:306391
palatal shelf hypoplasia J:306391
palatal shelves fail to meet at midline J:306391
perinatal lethality, complete penetrance J:306391
retrognathia J:306391
short tongue J:306391
small frontal bone J:306391
small mandible J:306391
small parietal bone J:306391
tongue hypoplasia J:306391
triangular face J:306391
Anp32etm1Mak/Anp32etm1Mak
Cfdp1tm1Dkwpd/Cfdp1tm2.1Dkwpd
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: 129 * C3H * C57BL/6 		normal abnormal intracellular organelle physiology J:349245
normal craniofacial phenotype J:349245
C2cd3em2Brgm/C2cd3em2Brgm
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: C3H * C57BL/6 		abnormal cilium physiology J:308674
abnormal tongue morphology J:308674
cleft palate J:308674
delayed bone ossification J:308674
C2cd3tm1c(EUCOMM)Wtsi/C2cd3tm1c(EUCOMM)Wtsi
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: C3H * C57BL/6 		abnormal cilium physiology J:308674
abnormal facial morphology J:308674
cleft palate J:308674
delayed bone ossification J:308674
tongue hypoplasia J:308674
Cfdp1tm1Dkwpd/Cfdp1tm2.1Dkwpd
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: 129 * 129S2/SvPas * C3H * C57BL/6 		abnormal craniofacial morphology J:349245
abnormal incisor morphology J:349245
abnormal intracellular organelle physiology J:349245
abnormal intramembranous bone ossification J:349245
abnormal maxilla morphology J:349245
flat head J:349245
short mandible J:349245
small mandible J:349245
Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi
E2f1Tg(Wnt1-cre)2Sor/E2f1+
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
involves: 129 * C3H * C57BL/6 * C57BL/6N 		abnormal conotruncal ridge morphology J:298597
abnormal cranial neural crest cell migration J:298597
abnormal embryonic tissue physiology J:298597
abnormal pharyngeal arch morphology J:298597
double outlet right ventricle J:298597
impaired cranial neural crest cell differentiation J:298597
interrupted aortic arch, type b J:298597
perinatal lethality, complete penetrance J:298597
pulmonary trunk hypoplasia J:298597
small frontal bone J:298597
small mandible J:298597
small maxilla J:298597
ventricular septal defect J:298597
E2f1Tg(Wnt1-cre)2Sor/E2f1+
Snrpbem1Lajm/Snrpb+
involves: C3H * C57BL/6 * C57BL/6J * CD1 		abnormal cranial ganglia morphology J:326544
abnormal cranium morphology J:326544
abnormal DNA-templated transcription J:326544
abnormal embryonic tissue morphology J:326544
abnormal forebrain morphology J:326544
abnormal frontonasal prominence morphology J:326544
abnormal geniculate ganglion morphology J:326544
abnormal glossopharyngeal nerve morphology J:326544
abnormal head development J:326544
abnormal head shape J:326544
abnormal jaw morphology J:326544
abnormal mandible morphology J:326544
abnormal mandibular nerve morphology J:326544
abnormal maxillary nerve morphology J:326544
abnormal metopic suture morphology J:326544
abnormal nasopharynx morphology J:326544
abnormal nose morphology J:326544
abnormal ophthalmic nerve morphology J:326544
abnormal premaxilla morphology J:326544
abnormal temporal bone morphology J:326544
abnormal tracheal cartilage morphology J:326544
abnormal trigeminal nerve morphology J:326544
abnormal vagus nerve morphology J:326544
abnormal vestibular ganglion morphology J:326544
absent alisphenoid bone J:326544
absent aorticopulmonary septum J:326544
absent frontonasal prominence J:326544
absent gastric milk in neonates J:326544
absent hyoid bone J:326544
absent mandibular angle J:326544
absent mandibular condyloid process J:326544
absent mandibular coronoid process J:326544
absent maxillary prominence J:326544
absent nasal septum J:326544
absent tympanic ring J:326544
absent zygomatic arch J:326544
athymia J:326544
basisphenoid bone hypoplasia J:326544
cleft palate J:326544
domed cranium J:326544
ectopic bone J:326544
ectopic cartilage J:326544
edema J:326544
enlarged lateral ventricles J:326544
first pharyngeal arch hypoplasia J:326544
frontal bone hypoplasia J:326544
frontonasal prominence hypoplasia J:326544
hindbrain hypoplasia J:326544
hyoid bone hypoplasia J:326544
interparietal bone hypoplasia J:326544
lethality throughout fetal growth and development, incomplete penetrance J:326544
mandible hypoplasia J:326544
mandibular prominence hypoplasia J:326544
maxilla hypoplasia J:326544
maxillary prominence hypoplasia J:326544
Meckel's cartilage hypoplasia J:326544
midbrain hypoplasia J:326544
nasal bone hypoplasia J:326544
neonatal lethality, complete penetrance J:326544
parietal bone hypoplasia J:326544
pharyngeal arch hypoplasia J:326544
short snout J:326544
small dorsal root ganglion J:326544
small ears J:326544
small temporal bone squamous part J:326544
thin cerebral cortex J:326544
E2f1Tg(Wnt1-cre)2Sor/E2f1+
Snrpbem1Lajm/Snrpb+
Trp53tm1Brn/Trp53+
involves: 129P2/OlaHsd * C3H * C57BL/6 * CD1 		abnormal craniofacial morphology J:326544
E2f1Tg(Wnt1-cre)2Sor/E2f1+
Snrpbem1Lajm/Snrpb+
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * C3H * C57BL/6 * CD1 		abnormal bone ossification J:326544
abnormal mandible morphology J:326544
cleft palate J:326544
microcephaly J:326544
micrognathia J:326544
perinatal lethality, complete penetrance J:326544
short snout J:326544
E2f1tm1Meg/E2f1+
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129 * C57BL/6 * FVB/N * NMRI 		abnormal eye development J:124204
E2f1tm1Meg/E2f1+
Phactr4humdy/Phactr4humdy
involves: 129S4/SvJae * C57BL/6J 		exencephaly J:123924
normal vision/eye phenotype J:123924
E2f1tm1Meg/E2f1+
Tg(CAG-Tfb1m)AGsha/0
involves: 129S4/SvJae * C57BL/6J * SJL/J 		normal hearing/vestibular/ear phenotype J:181548
E2f1tm1Meg/E2f1tm1Meg
E2f2tm1Zubi/E2f2tm1Zubi
E2f3tm2.1Gle/E2f3tm2.1Gle
involves: 129 * FVB/N * NIH Black Swiss 		decreased cell proliferation J:138289
perinatal lethality J:138289
E2f1tm1Meg/E2f1tm1Meg
E2f2tm1Zubi/E2f2tm1Zubi
E2f3tm3.1Gle/E2f3tm3.1Gle
involves: 129 * FVB/N * NIH Black Swiss 		decreased body weight J:138289
decreased cell proliferation J:138289
normal mortality/aging J:138289
E2f1tm1Meg/E2f1tm1Meg
E2f3tm1.1Gle/E2f3tm1.1Gle
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129 * C57BL/6 * FVB/N * NMRI 		normal vision/eye phenotype J:124204
E2f1tm1Meg/E2f1tm1Meg
E2f3tm2.1Gle/E2f3tm2.1Gle
involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss 		abnormal adrenal cortex morphology J:138289
abnormal brain size J:138289
abnormal corpus luteum morphology J:138289
abnormal epiphyseal plate morphology J:138289
abnormal lung epithelium morphology J:138289
normal adipose tissue phenotype J:138289
normal behavior/neurological phenotype J:138289
decreased body size J:138289
decreased body weight J:138289
decreased cell proliferation J:138289
decreased circulating growth hormone level J:138289
decreased circulating insulin-like growth factor I level J:138289
decreased circulating leptin level J:138289
decreased circulating triglyceride level J:138289
decreased survivor rate J:138289
decreased white adipose tissue amount J:138289
normal digestive/alimentary phenotype J:138289
female infertility J:138289
male infertility J:138289
ovary hypoplasia J:138289
premature death J:138289
testis hypoplasia J:138289
E2f1tm1Meg/E2f1tm1Meg
E2f3tm3.1Gle/E2f3tm3.1Gle
involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss 		decreased body weight J:138289
E2f1tm1Meg/E2f1tm1Meg
E2f3tm4Gle/E2f3tm4Gle
involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss 		no abnormal phenotype detected J:138289
E2f1tm1Meg/E2f1tm1Meg
E2f3tm5(E2f1)Gle/E2f3tm5(E2f1)Gle
involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss 		no abnormal phenotype detected J:138289
E2f1tm1Meg/E2f1tm1Meg
H2-Oa/Brd2Tg(otx2-lacZ)F5pImat/H2-Oa/Brd2Tg(otx2-lacZ)F5pImat
involves: 129S4/SvJae * CD-1 		normal embryo phenotype J:188139
normal nervous system phenotype J:188139
E2f1tm1Meg/E2f1tm1Meg
Phactr4humdy/Phactr4humdy
involves: 129S4/SvJae * C57BL/6J 		exencephaly J:123924
normal vision/eye phenotype J:123924
E2f1tm1Meg/E2f1tm1Meg
Rb1tm1Tyj/Rb1tm1Tyj
Tg(Rb1)1Blg/0
involves: 129S2/SvPas * 129S4/SvJae 		abnormal cell cycle J:65679
abnormal muscle physiology J:65679
abnormal skeletal muscle fiber morphology J:65679
hunched posture J:65679
hyporesponsive to tactile stimuli J:65679
polyploidy J:65679
E2f1tm1Meg/E2f1tm1Meg
Rb1tm2.1Fad/Rb1tm2.1Fad
involves: 129S4/SvJae * C57BL/6 		normal cellular phenotype J:215358
normal neoplasm J:215358
postnatal lethality, incomplete penetrance J:215358
E2f1tm1Meg/E2f1tm1Meg
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129 * C57BL/6 * FVB/N * NMRI 		abnormal amacrine cell morphology J:124204
abnormal cone electrophysiology J:124204
abnormal retina bipolar cell morphology J:124204
abnormal retina inner plexiform layer morphology J:124204
abnormal retina morphology J:124204
decreased retina ganglion cell number J:124204
thin retina outer nuclear layer J:124204
E2f1tm1Njd/E2f1+
Rb1tm1Tyj/Rb1+
either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6) 		increased thyroid adenoma incidence J:47108
increased tumor incidence J:47108
premature death J:47108
E2f1tm1Njd/E2f1+
Rb1tm1Tyj/Rb1tm1Tyj
either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6) 		prenatal lethality, complete penetrance J:47108
E2f1tm1Njd/E2f1+
E2f3tm1Lees/E2f3tm1Lees
involves: 129S2/SvPas 		lethality throughout fetal growth and development, complete penetrance J:75765
E2f1tm1Njd/E2f1tm1Njd
E2f3tm1Lees/E2f3+
involves: 129S2/SvPas 		slow postnatal weight gain J:75765
testicular atrophy J:75765
E2f1tm1Njd/E2f1tm1Njd
E2f3tm1Lees/E2f3tm1Lees
involves: 129S2/SvPas 		embryonic lethality during organogenesis, complete penetrance J:75765
E2f1tm1Njd/E2f1tm1Njd
E2f3tm2Lees/E2f3tm2Lees
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 		abnormal cartilage morphology J:147270
abnormal cell cycle J:147270
abnormal chondrocyte morphology J:147270
abnormal long bone epiphyseal plate morphology J:147270
decreased body weight J:147270
decreased cell proliferation J:147270
neonatal lethality, incomplete penetrance J:147270
E2f1tm1Njd/E2f1tm1Njd
E2f3tm3Lees/E2f3tm3Lees
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 		no abnormal phenotype detected J:147270
E2f1tm1Njd/E2f1tm1Njd
Klhl40tm1.1Itl/Klhl40tm1.1Itl
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6N 		decreased body size J:227534
normal mortality/aging J:227534
E2f1tm1Njd/E2f1tm1Njd
Rb1tm1Tyj/Rb1+
either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6) 		abnormal thyroid gland morphology J:47108
adrenal medulla hyperplasia J:47108
increased hemangioma incidence J:47108
increased pituitary gland tumor incidence J:47108
increased thyroid adenoma incidence J:47108
premature death J:47108
uterine hemorrhage J:47108
E2f1tm1Njd/E2f1tm1Njd
Rb1tm1Tyj/Rb1tm1Tyj
either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6) 		prenatal lethality, complete penetrance J:47108
E2f1tm1Njd/E2f1tm1Njd
Trp53tm1Brd/Trp53tm1Brd
involves: 129S2/SvPas * 129S7/SvEvBrd * SKH1 		increased sensitivity to skin irradiation J:97525
H2-Oa/Brd2Tg(otx2-lacZ)F5pImat/H2-Oa/Brd2Tg(otx2-lacZ)F5pImat
E2f1tm1Meg/E2f1tm1Meg
involves: 129S4/SvJae * CD-1 		normal embryo phenotype J:188139
normal nervous system phenotype J:188139
Hand1tm2Eno/Hand1tm3Abfi
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: 129S6/SvEvTac * C3H * C57BL/6 		abnormal craniofacial development J:214092
abnormal maxillary prominence morphology J:214092
abnormal nasal capsule morphology J:214092
abnormal palatal shelf fusion at midline J:214092
abnormal pharyngeal arch morphology J:214092
abnormal secondary palate development J:214092
abnormal tongue position J:214092
absent nasal septum J:214092
basisphenoid bone hypoplasia J:214092
midline facial cleft J:214092
nasal bone hypoplasia J:214092
neonatal lethality J:214092
Hand1tm2Eno/Hand1tm4Abfi
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: 129S6/SvEvTac * C3H * C57BL/6 		abnormal craniofacial development J:214092
abnormal maxillary prominence morphology J:214092
abnormal nasal capsule morphology J:214092
abnormal palatal shelf fusion at midline J:214092
abnormal pharyngeal arch morphology J:214092
abnormal secondary palate development J:214092
absent middle ear ossicles J:214092
absent nasal septum J:214092
decreased maxillary shelf size J:214092
decreased palatine bone horizontal plate size J:214092
mandible hypoplasia J:214092
middle ear ossicle hypoplasia J:214092
midline facial cleft J:214092
neonatal lethality J:214092
temporal bone squamous part hypoplasia J:214092
Hand1tm3Abfi/Hand1+
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: C3H * C57BL/6 		abnormal alisphenoid bone morphology J:214092
abnormal basicranium morphology J:214092
abnormal maxilla morphology J:214092
abnormal nasal capsule morphology J:214092
abnormal palatal shelf fusion at midline J:214092
abnormal pharyngeal arch morphology J:214092
abnormal Reichert's cartilage morphology J:214092
abnormal sagittal suture morphology J:214092
abnormal secondary palate development J:214092
abnormal tongue position J:214092
absent nasal bone J:214092
absent nasal septum J:214092
absent temporal bone squamous part J:214092
basisphenoid bone hypoplasia J:214092
frontal bone hypoplasia J:214092
interparietal bone hypoplasia J:214092
mandible hypoplasia J:214092
midline facial cleft J:214092
neonatal lethality J:214092
pterygoid bone hypoplasia J:214092
short Meckel's cartilage J:214092
short premaxilla J:214092
zygomatic bone hypoplasia J:214092
Hand1tm4Abfi/Hand1+
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: C3H * C57BL/6 		abnormal alisphenoid bone morphology J:214092
abnormal nasal capsule morphology J:214092
abnormal palatal shelf fusion at midline J:214092
abnormal pharyngeal arch morphology J:214092
abnormal tongue position J:214092
absent nasal septum J:214092
midline facial cleft J:214092
nasal bone hypoplasia J:214092
neonatal lethality J:214092
premaxilla hypoplasia J:214092
small mandible J:214092
temporal bone squamous part hypoplasia J:214092
Kctd1tm1c(EUCOMM)Wtsi/Kctd1+
Kctd15tm1c(EUCOMM)Wtsi/Kctd15+
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: 129S4/SvJae * C57BL/6J * C57BL/6N 		normal craniofacial phenotype J:344153
normal integument phenotype J:344153
normal pigmentation phenotype J:344153
Kctd1tm1c(EUCOMM)Wtsi/Kctd1+
Kctd15tm1c(EUCOMM)Wtsi/Kctd15tm1c(EUCOMM)Wtsi
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: 129S4/SvJae * C57BL/6J * C57BL/6N 		belly spot J:344153
Kctd1tm1c(EUCOMM)Wtsi/Kctd1tm1c(EUCOMM)Wtsi
Kctd15tm1c(EUCOMM)Wtsi/Kctd15+
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: 129S4/SvJae * C57BL/6J * C57BL/6N 		belly spot J:344153
Kctd1tm1c(EUCOMM)Wtsi/Kctd1tm1c(EUCOMM)Wtsi
Kctd15tm1c(EUCOMM)Wtsi/Kctd15tm1c(EUCOMM)Wtsi
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: 129S4/SvJae * C57BL/6J * C57BL/6N 		abnormal cranial suture morphology J:344153
abnormal craniofacial development J:344153
abnormal eyelid development J:344153
abnormal heart morphology J:344153
abnormal intramembranous bone ossification J:344153
abnormal nasal cartilage morphology J:344153
abnormal nose morphology J:344153
abnormal scalp morphology J:344153
absent incisors J:344153
absent lower incisors J:344153
absent nasal bone J:344153
absent upper incisors J:344153
bicuspid aortic valve J:344153
delayed cranial suture closure J:344153
delayed intramembranous bone ossification J:344153
ectopic neuron J:344153
eyelids open at birth J:344153
overriding aortic valve J:344153
perimembraneous ventricular septal defect J:344153
short frontal bone J:344153
skin lesions J:344153
small nasal bone J:344153
thin epidermis J:344153
wide metopic suture J:344153
Kctd15tm1c(EUCOMM)Wtsi/Kctd15tm1c(EUCOMM)Wtsi
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: 129S4/SvJae * C57BL/6J * C57BL/6N 		belly spot J:344153
normal cardiovascular system phenotype J:344153
Mmachcem1Poche/Mmachcem1Poche
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6J 		normal craniofacial phenotype J:317822
Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J 		abnormal craniofacial bone morphology J:279139
abnormal frontal bone morphology J:279139
abnormal nasal bone morphology J:279139
abnormal palatal mesenchymal cell proliferation J:279139
absent palatine bone horizontal plate J:279139
normal cardiovascular system phenotype J:279139
cleft secondary palate J:279139
decreased bone ossification J:279139
normal endocrine/exocrine gland phenotype J:279139
frontal bone hypoplasia J:279139
neonatal lethality, complete penetrance J:279139
palatal shelves fail to meet at midline J:279139
normal skeleton phenotype J:279139
small mandible J:279139
Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk
E2f1Tg(Wnt1-cre)2Sor/E2f1+
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
involves: 129S/Sv * 129X1/SvJ * C57BL/6J 		normal cellular phenotype J:279139
normal embryo phenotype J:279139
Sox9tm2Crm/Sox9+
Rr80em1Jwsk/Rr80+
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: 129S7/SvEvBrd * C3H * C57BL/6J * FVB/NJ 		abnormal mandible morphology J:306395
mandibular condyloid process hypoplasia J:306395
postnatal growth retardation J:306395
short mandible J:306395
Tg(ACTB-Edn1)721Clou/0
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: 129S4/SvJae * C3H * C57BL/6 		abnormal mandible morphology J:221133
abnormal Meckel's cartilage morphology J:221133
abnormal temporal bone squamous part morphology J:221133
absent palatine bone J:221133
absent zygomatic bone J:221133
basisphenoid bone hypoplasia J:221133
cleft palate J:221133
midline facial cleft J:221133
upper jaw to lower jaw transformation J:221133
Tg(ACTB-Edn1)1398Clou/0
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: 129S4/SvJae * C3H * C57BL/6 		abnormal incus morphology J:221133
abnormal malleus morphology J:221133
abnormal mandibular angle morphology J:221133
abnormal zygomatic bone morphology J:221133
absent mandibular coronoid process J:221133
cleft palate J:221133
ectopic cranial bone J:221133
gonial bone hypoplasia J:221133
palatine bone hypoplasia J:221133
temporal bone squamous part hypoplasia J:221133
tympanic ring hypoplasia J:221133
upper jaw to lower jaw transformation J:221133
Tg(ACTB-Edn1)1408Clou/0
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: 129S4/SvJae * C3H * C57BL/6 		normal craniofacial phenotype J:221133
Tg(ACTB-Edn1)1416Clou/0
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: 129S4/SvJae * C3H * C57BL/6 		abnormal mandibular angle morphology J:221133
abnormal Meckel's cartilage morphology J:221133
absent mandibular coronoid process J:221133
ectopic cartilage J:221133
malleus hypoplasia J:221133
midline facial cleft J:221133
palatine bone hypoplasia J:221133
temporal bone squamous part hypoplasia J:221133
tympanic ring hypoplasia J:221133
upper jaw to lower jaw transformation J:221133
Thap11tm1Tpz/Thap11em1Poche
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J 		belly spot J:317822
decreased digit pigmentation J:317822
Thap11tm1Tpz/Thap11tm1Tpz
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C3H * C57BL/6 		abnormal craniofacial development J:317822
Vegfatm2Gne/Vegfatm2Gne
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: 129/Sv * C3H * C57BL/6 		abnormal intramembranous bone ossification J:309228
abnormal mandible morphology J:309228
abnormal maxilla morphology J:309228
abnormal palatal mesenchymal cell proliferation J:309228
abnormal palatal shelf bone ossification J:309228
abnormal palatal shelf elevation J:309228
abnormal secondary palate development J:309228
abnormal vascular development J:309228
decreased palatal shelf size J:309228
palatal shelf hypoplasia J:309228
palatal shelves fail to meet at midline J:309228
poor arterial differentiation J:309228
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory