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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nfatc1
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
MGI:102469
80 phenotypes from 7 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nfatc1em1(IMPC)Bay/Nfatc1+
C57BL/6N-Nfatc1em1(IMPC)Bay/BayMmucd 		abnormal locomotor behavior J:211773
decreased locomotor activity J:211773
Nfatc1em1(IMPC)Bay/Nfatc1em1(IMPC)Bay
C57BL/6N-Nfatc1em1(IMPC)Bay/BayMmucd 		preweaning lethality, complete penetrance J:211773
Nfatc1tm1.1Fbs/Nfatc1tm1.1Fbs
C57BL/6-Nfatc1tm1.1Fbs 		decreased interferon-gamma secretion J:305649
decreased interleukin-17 secretion J:305649
decreased susceptibility to experimental autoimmune encephalomyelitis J:305649
decreased susceptibility to graft versus host disease J:305649
normal immune system phenotype J:305649
increased interleukin-2 secretion J:305649
increased regulatory T cell number J:305649
Nfatc1tm1Glm/Nfatc1tm1Glm
B6.129S2-Nfatc1tm1Glm 		abnormal cardiac outflow tract development J:185683
abnormal semilunar valve morphology J:185683
decreased atrioventricular cushion size J:185683
Nfatc1tm1Glm/Nfatc1tm1Glm
involves: 129S2/SvPas 		abnormal blood circulation J:99892
abnormal cardiovascular system physiology J:46398
abnormal heart morphology J:46398
abnormal semilunar valve morphology J:46398
absent aortic valve cusps J:46398
absent pulmonary valve cusps J:46398
edema J:46398
gastrointestinal hemorrhage J:46398
lethality throughout fetal growth and development, complete penetrance J:46398
pallor J:46398
pericardial effusion J:46398
semilunar valve regurgitation J:99892
ventricular septal defect J:46398
Nfatc1tm1Glm/Nfatc1tm2Glm
chimera involves: 129S2/SvPas 		abnormal B cell physiology J:78376
abnormal immune system physiology J:78376
abnormal immunoglobulin level J:78376
abnormal interferon-gamma secretion J:78376
abnormal interleukin-2 secretion J:78376
abnormal lymphocyte cell number J:78376
abnormal lymphocyte physiology J:78376
abnormal T cell physiology J:78376
abnormal T-helper 2 physiology J:78376
decreased double-positive T cell number J:78376
decreased IgE level J:78376
decreased IgG1 level J:78376
decreased IgG2b level J:78376
decreased IgG3 level J:78376
decreased immunoglobulin level J:78376
decreased interleukin-4 secretion J:78376
decreased lymphocyte cell number J:78376
increased double-negative T cell number J:78376
increased IgA level J:78376
increased IgG2a level J:78376
increased IgM level J:78376
increased immunoglobulin level J:78376
Nfatc1tm1Mak/Nfatc1tm1Mak
involves: 129P2/OlaHsd * C57BL/6 		abnormal cardiac outflow tract development J:46399
abnormal interventricular septum morphology J:46399
abnormal mitral valve cusp morphology J:46399
abnormal mitral valve development J:46399
abnormal semilunar valve development J:46399
abnormal tricuspid valve cusp morphology J:46399
abnormal tricuspid valve development J:46399
anemia J:46399
cardiac hypertrophy J:46399
edema J:46399
embryo tissue necrosis J:46399
lethality throughout fetal growth and development, complete penetrance J:46399
Nfatc1tm1Rao/Nfatc1tm1Rao
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c 		abnormal B cell calcium ion homeostasis J:177319
abnormal class switch recombination J:177319
abnormal marginal zone B cell physiology J:177319
decreased B cell number J:177319
decreased B cell proliferation J:177319
decreased B-1a cell number J:177319
decreased susceptibility to experimental autoimmune encephalomyelitis J:177319
increased B cell apoptosis J:177319
Nfatc1tm1Rao/Nfatc1tm1Rao
Tg(Fcer2a-cre)5Mbu/0
involves: C57BL/6 * CBA 		abnormal B cell physiology J:177319
abnormal class switch recombination J:177319
decreased B cell proliferation J:177319
decreased IgG2a level J:177319
decreased IgG3 level J:177319
decreased IgM level J:177319
decreased interleukin-2 secretion J:177319
increased IgM level J:177319
increased interleukin-10 secretion J:177319
Nfatc1tm3Glm/Nfatc1tm3Glm
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6 		normal skeleton phenotype J:144598
Nfatc1tm3Glm/Nfatc1tm3Glm
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA 		abnormal endochondral bone ossification J:144598
abnormal mandibular condyloid process morphology J:144598
abnormal osteoclast differentiation J:144598
absent lower incisors J:144598
decreased length of long bones J:144598
decreased osteoclast cell number J:144598
increased width of hypertrophic chondrocyte zone J:144598
long upper incisors J:144598
osteopetrosis J:144598
short femur J:144598
short lower incisors J:144598
short tibia J:144598
Nfatc1tm3Glm/Nfatc1tm3Glm
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/?
involves: C57BL/6 * CD-1 		normal skeleton phenotype J:144598
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory