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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nfatc1
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
MGI:102469
62 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Adgrg6em3Jlp/Adgrg6em3Jlp
Nfatc1tm1.1(cre)Bz/Nfatc1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:315981
Ccm2tm1Mlkn/Ccm2tm1Mlkn
Nfatc1tm1.1(cre)Bz/Nfatc1+
involves: 129 * 129S1/Sv * 129X1/SvJ 		decreased cardiac jelly amount J:238897
lethality throughout fetal growth and development, complete penetrance J:238897
thin myocardium J:238897
Creld1tm1c(EUCOMM)Wtsi/Creld1tm1c(EUCOMM)Wtsi
Nfatc1tm1.1(cre)Bz/Nfatc1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * SJL 		no abnormal phenotype detected J:304446
Dzip1tm1Sasl/Dzip1tm1Sasl
Nfatc1tm1.1(cre)Bz/Nfatc1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal mitral valve cusp morphology J:291454
abnormal mitral valve morphology J:291454
mitral valve prolapse J:291454
Hivep3tm1Glm/Hivep3tm1Glm
Nfatc1tm3Glm/Nfatc1tm3Glm
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA 		increased bone volume J:184764
Ift88tm1Bky/Ift88tm1Bky
Nfatc1tm1.1(cre)Bz/Nfatc1+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal mitral valve cusp morphology J:291454
abnormal mitral valve morphology J:291454
abnormal motile cilium morphology J:291454
Kdrtm1Wag/Kdrtm1Wag
Nfatc1tm1.1(cre)Bz/Nfatc1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal angiogenesis J:193198
abnormal coronary artery morphology J:193198
abnormal interventricular septum morphology J:193198
decreased body size J:193198
heart hemorrhage J:193198
lethality throughout fetal growth and development, complete penetrance J:193198
Kdrtm1Wag/Kdrtm1Wag
Nfatc1tm1.1(cre)Bz/Nfatc1+
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 		abnormal angiogenesis J:193198
abnormal coronary artery morphology J:193198
Krit1tm1Kwhi/Krit1tm1Kwhi
Map3k3tm1.1Mlkn/Map3k3+
Nfatc1tm1.1(cre)Bz/Nfatc1+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl * C57BL/6NTac 		decreased cardiac jelly amount J:238897
Krit1tm1Kwhi/Krit1tm1Kwhi
Nfatc1tm1.1(cre)Bz/Nfatc1+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl 		abnormal heart morphology J:238897
abnormal myocardial trabeculae morphology J:238897
decreased cardiac jelly amount J:238897
dilated heart atrium J:238897
dilated heart ventricle J:238897
lethality throughout fetal growth and development, complete penetrance J:238897
thin myocardium J:238897
Map3k3tm1.1Mlkn/Map3k3tm1.2Mlkn
Nfatc1tm1.1(cre)Bz/Nfatc1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac 		embryonic lethality during organogenesis J:238897
thin myocardium J:238897
Nfatc1tm1(cre)Bz/Nfatc1+
Smarca4tm1.2Pcn/Smarca4tm1.2Pcn
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ 		abnormal aortic valve morphology J:226941
abnormal heart ventricle morphology J:226941
bicuspid aortic valve J:226941
cardiomyopathy J:226941
enlarged heart J:226941
normal mortality/aging J:226941
thick aortic valve cusps J:226941
thick pulmonary valve J:226941
Nfatc1tm1.1(cre)Bz/Nfatc1+
Smarca4tm1.2Pcn/Smarca4tm1.2Pcn
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ 		abnormal aortic sinus morphology J:226941
abnormal aortic valve cusp morphology J:226941
abnormal aortic valve morphology J:226941
abnormal cardiac outflow tract development J:226941
abnormal coronary artery morphology J:226941
abnormal coronary vein morphology J:226941
abnormal pulmonary valve cusp morphology J:226941
abnormal semilunar valve morphology J:226941
bicuspid aortic valve J:226941
enlarged heart J:226941
lethality throughout fetal growth and development, incomplete penetrance J:226941
perimembraneous ventricular septal defect J:226941
perinatal lethality J:226941
thick aortic valve J:226941
thick heart valve cusps J:226941
thick myocardium J:226941
thick pulmonary valve J:226941
Nfatc1tm1.1(cre)Bz/Nfatc1+
Sema6dtm1.1Jiao/Sema6dtm1.1Jiao
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/Sv * C57BL/6 		abnormal atrioventricular cushion morphology J:254695
abnormal cardiac epithelial to mesenchymal transition J:254695
Nfatc1tm1Glm/Nfatc1tm1Glm
Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * CBA 		abnormal cardiac outflow tract development J:185683
Nfatc1tm1Glm/Nfatc1tm1Glm
Tg(Tek-cre)1Ywa/0
Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * SJL 		abnormal cardiac outflow tract development J:185683
Nfatc1tm1Rao/Nfatc1tm1Rao
Nfatc2tm1Rao/Nfatc2tm1Rao
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c 		abnormal B cell physiology J:177319
decreased interleukin-2 secretion J:177319
Nfatc1tm3Glm/Nfatc1tm3Glm
Sh3bp2tm1Bjro/Sh3bp2tm1Bjro
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA 		abnormal osteoclast differentiation J:144598
decreased osteoclast cell number J:144598
liver inflammation J:144598
lung inflammation J:144598
lymph node inflammation J:144598
normal skeleton phenotype J:144598
stomach inflammation J:144598
Pdcd10tm1Kwhi/Pdcd10tm1Kwhi
Nfatc1tm1.1(cre)Bz/Nfatc1+
involves: 129S1/Sv * 129X1/SvJ 		abnormal cardiac jelly morphology J:238897
lethality throughout fetal growth and development, complete penetrance J:238897
thin myocardium J:238897
Smarca4tm1.2Pcn/Smarca4tm1.2Pcn
Nfatc1tm1.1(cre)Bz/Nfatc1+
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ 		abnormal semilunar valve morphology J:226941
Sox7tm1.1Nat/Sox7tm1.1Nat
Nfatc1tm1.1(cre)Bz/Nfatc1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal cardiac epithelial to mesenchymal transition J:306193
abnormal interventricular septum morphology J:306193
atrial septal defect J:306193
atrioventricular cushion hypoplasia J:306193
normal embryo phenotype J:306193
normal mortality/aging J:306193
partial atrioventricular septal defect J:306193
Tbx20tm1Sev/Tbx20tm1.1Sev
Nfatc1tm1.1(cre)Bz/Nfatc1+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Black Swiss 		abnormal cardiovascular system physiology J:198628
abnormal heart valve morphology J:198628
aortic valve regurgitation J:198628
decreased atrioventricular cushion size J:198628
hemorrhage J:198628
lethality throughout fetal growth and development, complete penetrance J:198628
small atrioventricular valve J:198628
small semilunar valve J:198628
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory