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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tbx5
T-box 5
MGI:102541
63 phenotypes from 3 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pax3tm1(cre)Joe/Pax3+
Tbx5tm1Jse/Tbx5tm1Jse
Not Specified 		normal limbs/digits/tail phenotype J:157917
Tbx5tm1.1Jse/Tbx5+
either: (involves: 129/Sv) or (involves: Black Swiss) 		abnormal atrioventricular bundle morphology J:92050
abnormal atrioventricular node conduction J:92050
abnormal cardiovascular system physiology J:112887
abnormal impulse conducting system conduction J:92050
abnormal impulse conducting system morphology J:92050
abnormal left posterior bundle morphology J:92050
abnormal right bundle morphology J:92050
abnormal sinoatrial node conduction J:112887
abnormal sinus arrhythmia J:112887
atrial septal defect J:112887
atrioventricular block J:112887
dilated heart atrium J:112887
perinatal lethality, incomplete penetrance J:112887
prolonged PQ interval J:92050, J:112887
prolonged QRS complex duration J:92050
ventricular tachycardia J:112887
Tbx5tm1.1Jse/Tbx5+
involves: 129/Sv * Black Swiss 		abnormal carpal bone morphology J:71845
abnormal heart ventricle shape J:71845
abnormal impulse conducting system conduction J:71845
abnormal phalanx morphology J:71845
atrioventricular block J:71845
dilated heart atrium J:71845
enlarged heart J:71845
hydrops fetalis J:71845
muscular ventricular septal defect J:71845
ostium primum atrial septal defect J:71845
pericardial effusion J:71845
perimembraneous ventricular septal defect J:71845
perinatal lethality, incomplete penetrance J:71845
prolonged P wave J:71845
prolonged PR interval J:71845
sinoatrial block J:71845
ventricular septal defect J:71845
Tbx5tm1.1Jse/Tbx5+
involves: Black Swiss 		abnormal digit morphology J:105332
abnormal heart morphology J:105332
Tbx5tm1.1Jse/Tbx5tm1.1Jse
either: (involves: 129/SvEv) or (involves: Black Swiss) 		abnormal heart development J:71845
abnormal heart morphology J:112887
abnormal heart tube morphology J:71845
absent atrioventricular cushions J:71845
common atrium J:71845
embryonic growth arrest J:71845
embryonic lethality during organogenesis, complete penetrance J:71845, J:112887
failure of heart looping J:71845
Tbx5tm1.2Jse/Tbx5tm1.2Jse
involves: 129S/SvEv * 129X1/SvJ 		no abnormal phenotype detected J:112887
Tbx5tm1.2Jse/Tbx5tm1.2Jse
Not Specified 		atrioventricular block J:190765
ventricular premature beat J:190765
ventricular tachycardia J:190765
Tbx5tm1.2Jse/Tbx5tm1.2Jse
Tg(Kcne1-cre/ERT2)1Imos/0
involves: CD-1 		abnormal atrioventricular bundle conduction J:190765
abnormal impulse conducting system conduction J:190765
abnormal induced morbidity/mortality J:190765
atrioventricular block J:190765
normal cardiovascular system phenotype J:190765
irregular heartbeat J:190765
premature death J:190765
ventricular premature beat J:190765
ventricular tachycardia J:190765
Tbx5tm1Jse/Tbx5+
involves: 129S/SvEv 		abnormal cardiovascular system physiology J:112887
abnormal sinus arrhythmia J:112887
atrial septal defect J:112887
dilated heart atrium J:112887
postnatal lethality, incomplete penetrance J:112887
prolonged PQ interval J:112887
ventricular tachycardia J:112887
Tbx5tm1Jse/Tbx5tm1Jse
involves: 129S/SvEv 		abnormal heart atrium morphology J:112887
abnormal heart development J:112887
abnormal heart left ventricle morphology J:112887
embryonic growth arrest J:112887
embryonic lethality during organogenesis, complete penetrance J:112887
heart atrium hypoplasia J:112887
Tbx5tm1Jse/Tbx5tm1Jse
Tg(Prrx1-cre)1Cjt/0
involves: C57BL/6J * SJL/J 		abnormal abdominal wall morphology J:217810
abnormal forelimb bud morphology J:83258
abnormal thoracic cage morphology J:83258, J:217810
absent apical ectodermal ridge J:83258
absent clavicle J:83258
absent forelimb J:83258, J:217810
absent forelimb buds J:83258
absent scapula J:83258
absent sternum J:83258, J:217810
perinatal lethality J:83258
Tbx5tm1Jse/Tbx5tm1Jse
Tg(Prrx1-cre/ERT2)1Mlgn/0
Not Specified 		abnormal forelimb morphology J:157917
abnormal limb development J:157917
Tbx5tm1Jse/Tbx5tm1Jse
Tg(Prrx1-cre/ERT2)1Mlgn/0
Tg(Scx-GFP)1Stzr/0
Not Specified 		abnormal forelimb morphology J:157917
abnormal limb development J:157917
abnormal tendon morphology J:157917
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory