About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tsc2
TSC complex subunit 2
MGI:102548
97 phenotypes from 13 alleles in 18 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Amhr2tm3(cre)Bhr/Amhr2+
Tsc2tm1.1Mjg/Tsc2tm1.1Mjg
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 		abnormal seminiferous tubule epithelium morphology J:187754
abnormal seminiferous tubule morphology J:187754
abnormal Sertoli cell morphology J:187754
abnormal spermatogenesis J:187754
abnormal testis morphology J:187754
decreased male germ cell number J:187754
decreased testis weight J:187754
increased Sertoli cell proliferation J:187754
normal neoplasm J:187754
small testis J:187754
Tg(CMV-Tsc2*)1Arbi/0
involves: C57BL/6 		abnormal cerebellum morphology J:96943
abnormal dermal layer morphology J:96943
abnormal motor learning J:179850
abnormal response to social novelty J:179850
abnormal social investigation J:179850
increased hamartoma incidence J:96943
increased skin hamartoma incidence J:96943
reduced long-term depression J:182345
Tg(GFAP-cre)8Gtm/0
Tsc2tm1.1Mjg/Tsc2tm1.1Mjg
involves: 129X1/SvJ * 129S1/Sv * C57BL/6 * CBA 		abnormal hippocampus pyramidal cell morphology J:167241
astrocytosis J:167241
increased brain size J:167241
increased brain weight J:167241
premature death J:167241
seizures J:167241
slow postnatal weight gain J:167241
Tg(Ins2-cre)23Herr/0
Tsc2tm1Kido/Tsc2tm1Kido
involves: 129S4/SvJae * C57BL/6 * C57BL/6J * CBA/J 		abnormal pancreatic islet morphology J:135811
decreased body weight J:135811
decreased circulating insulin level J:135811
decreased pancreatic beta cell number J:135811
hypoglycemia J:135811
improved glucose tolerance J:135811
increased circulating glucose level J:135811
increased circulating insulin level J:135811
increased insulin sensitivity J:135811
increased pancreatic beta cell mass J:135811
pancreatic islet hyperplasia J:135811
Tg(Pcp2-cre)2Mpin/0
Tsc2tm1.1Mjg/Tsc2tm1.1Mjg
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal gait J:174327
abnormal Purkinje cell morphology J:174327
ataxia J:174327
impaired coordination J:174327
Purkinje cell degeneration J:174327
Tg(Pcp2-cre)2Mpin/0
Tsc2tm1.1Mjg/Tsc2tm1.2Mjg
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal Purkinje cell morphology J:174327
postnatal lethality, incomplete penetrance J:174327
Purkinje cell degeneration J:174327
seizures J:174327
Tsc2tm1.1Kcess/Tsc2tm1.1Kcess
involves: 129S1/SvImJ * 129S4/SvJaeSor * 129S6/SvEvTac 		no abnormal phenotype detected J:195049
Tsc2tm1.1Kcess/Tsc2tm1.1Kcess
Emx1tm1(cre)Krj/Emx1+
involves: 129S/Sv * C57BL/6J 		decreased body weight J:195049
environmentally induced seizures J:195049
postnatal growth retardation J:195049
postnatal lethality, complete penetrance J:195049
Tsc2tm1.1Kido/Tsc2+
involves: 129S4/SvJae * C57BL/6 		increased kidney tumor incidence J:135811
Tsc2tm1.1Mjg/Tsc2tm1.1Mjg
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		no abnormal phenotype detected J:121748
Tsc2tm1.1Mjg/Tsc2tm1.1Mjg
Pgrtm2(cre)Lyd/Pgr+
involves: 129S1/Sv * 129X1/SvJ 		abnormal myometrium morphology J:221228
endometrium hyperplasia J:221228
enlarged uterus J:221228
increased endometrial gland number J:221228
increased lung tumor incidence J:221228
increased metastatic potential J:221228
increased uterus leiomyoma incidence J:221228
increased uterus weight J:221228
internal hemorrhage J:221228
Tsc2tm1.2Mjg/Tsc2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		increased adenoma incidence J:121748
kidney cyst J:121748
Tsc2tm1.2Mjg/Tsc2tm1.2Mjg
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		embryonic growth retardation J:121748
embryonic lethality during organogenesis, incomplete penetrance J:121748
Tsc2tm1Djk/Tsc2+
either: (involves: 129S4/SvJae * BALB/cJ) or (involves: 129S4/SvJae * Black Swiss) or (involves: 129S4/SvJae * C57BL/6J) 		increased extremity angiosarcoma incidence J:57631
increased hepatic hemangioma incidence J:57631
increased lung adenoma incidence J:57631
increased renal carcinoma incidence J:57631
increased renal cystadenoma incidence J:57631
increased tumor incidence J:57631
Tsc2tm1Djk/Tsc2+
involves: 129S4/SvJae * C57BL/6J 		abnormal autophagy J:217829
abnormal dendritic spine morphology J:217829
abnormal response to novel object J:217829
abnormal response to social novelty J:217829
abnormal social investigation J:217829
Tsc2tm1Djk/Tsc2+
involves: 129S4/SvJae * C57BL/6NCrl 		abnormal contextual conditioning behavior J:138621
abnormal spatial learning J:138621
normal behavior/neurological phenotype J:138621
enhanced long-term potentiation J:138621
normal nervous system phenotype J:138621
Tsc2tm1Djk/Tsc2tm1Djk
either: (involves: 129S4/SvJae * BALB/cJ) or (involves: 129S4/SvJae * Black Swiss) or (involves: 129S4/SvJae * C57BL/6J) 		embryonic lethality during organogenesis, complete penetrance J:57631
liver hypoplasia J:57631
Tsc2tm1Jusa/Tsc2+
Not Specified 		decreased myocardial infarct size J:186597
increased myocardial infarct size J:186597
Tsc2tm1Kcess/Tsc2tm1Kcess
involves: 129S1/SvImJ * 129S6/SvEvTac 		preweaning lethality, complete penetrance J:195049
Tsc2tm1Kido/Tsc2tm1Kido
involves: 129S4/SvJae * C57BL/6 		no abnormal phenotype detected J:135811
Tsc2tm1Mjg/Tsc2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		kidney cyst J:121748
Tsc2tm1Mjg/Tsc2tm1Mjg
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		decreased embryo size J:121748
embryonic lethality during organogenesis, incomplete penetrance J:121748
lethality throughout fetal growth and development, incomplete penetrance J:121748
open neural tube J:121748
pallor J:121748
prenatal lethality, complete penetrance J:121748
Tsc2tm1Tno/Tsc2+
B6J.129S4-Tsc2tm1Tno 		abnormal social investigation J:221239
decreased coping response J:221239
increased vertical activity J:221239
Tsc2tm1Tno/Tsc2+
involves: 129S4/SvJae 		abnormal dendrite morphology J:222712
abnormal dendritic spine morphology J:222712
normal nervous system phenotype J:222712
Tsc2tm1Tno/Tsc2+
involves: 129S4/SvJae * C57BL/6J 		increased hepatic hemangioma incidence J:52464
increased renal carcinoma incidence J:52464
Tsc2tm1Tno/Tsc2tm1Tno
involves: 129S4/SvJae * C57BL/6J 		abnormal endocardium morphology J:52464
abnormal heart ventricle morphology J:52464
decreased embryo size J:52464
embryonic growth retardation J:52464
embryonic lethality during organogenesis, incomplete penetrance J:52464
heart hyperplasia J:52464
incomplete rostral neuropore closure J:52464
thick myocardium J:52464
Tsc2tm2.1Djk/Tsc2tm2.1Djk
involves: 129S4/SvJae * C57BL/6 		no abnormal phenotype detected J:149326
Tsc2tm2.2Djk/Tsc2+
involves: 129S4/SvJae * C57BL/6 		increased renal cystadenoma incidence J:149326
Tsc2tm2.2Djk/Tsc2tm2.2Djk
involves: 129S4/SvJae * C57BL/6 		abnormal embryonic hematopoiesis J:149326
abnormal vascular development J:149326
dilated vasculature J:149326
embryonic growth retardation J:149326
increased apoptosis J:149326
internal hemorrhage J:149326
lethality throughout fetal growth and development, complete penetrance J:149326
liver hypoplasia J:149326
normal nervous system phenotype J:149326
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory