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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Myh11
myosin, heavy polypeptide 11, smooth muscle
MGI:102643
33 phenotypes from 5 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Myh11tm1.1Dmmz/Myh11tm1.1Dmmz
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 		abnormal cell adhesion J:212664
abnormal vascular smooth muscle physiology J:212664
abnormal vascular wound healing J:212664
normal cardiovascular system phenotype J:212664
decreased vasoconstriction J:212664
increased vascular smooth muscle cell proliferation J:212664
Myh11tm1.1Rng/Myh11tm1.1Rng
involves: 129/Sv * C57BL/6 		postnatal lethality, complete penetrance J:179478
Myh11tm1Bdr/Myh11tm1Bdr
Not Specified 		abnormal urinary bladder morphology J:82859
abnormal vascular regression J:82859
anuria J:82859
decreased mean systemic arterial blood pressure J:82859
dilated cardiomyopathy J:82859
dilated heart left ventricle J:82859
distended urinary bladder J:82859
impaired contractility of urinary bladder detrusor smooth muscle J:82859
increased circulating renin level J:82859
intestinal hypoperistalsis J:82859
neonatal lethality, incomplete penetrance J:82859
pallor J:82859
slow postnatal weight gain J:82859
thin ventricular wall J:82859
Myh11tm1Peri/Myh11+
involves: 129 * C57BL/6 		impaired smooth muscle contractility J:97927
Myh11tm1Peri/Myh11tm1Peri
involves: 129 * C57BL/6 		impaired smooth muscle contractility J:97927
Myh11tm1Peri/Myh11tm1Peri
Not Specified 		abnormal airway resistance J:97298
decreased bronchoconstrictive response J:97298
Myh11tm2Peri/Myh11tm2Peri
involves: 129 * C57BL/6 		abnormal digestive system morphology J:142230
abnormal muscle contractility J:142230
abnormal sarcomere morphology J:142230
decreased body weight J:142230
distended urinary bladder J:142230
hydronephrosis J:142230
increased physiological sensitivity to xenobiotic J:142230
ischuria J:142230
postnatal lethality, incomplete penetrance J:142230
premature death J:142230
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory