Ppp5c Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ppp5c
protein phosphatase 5, catalytic subunit
MGI:102666

34 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ppp5c^Gt(XG029)Byg/Ppp5c^Gt(XG029)Byg involves: 129P2/OlaHsd * C57BL/6J	abnormal cell cycle checkpoint function	J:122564
Ppp5c^tm1.2Rhon/Ppp5c^tm1.2Rhon B6.129X1-Ppp5c^tm1.2Rhon	abnormal cell adhesion	J:178164
	abnormal cell morphology	J:178164
	decreased body weight	J:178164
	decreased fibroblast proliferation	J:178164
	decreased litter size	J:178164
	enlarged spleen	J:178164
	lethality, incomplete penetrance	J:178164
Ppp5c^tm1.2Rhon/Ppp5c^tm1.2Rhon either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J * FVB/N)	no abnormal phenotype detected	J:178164
Ppp5c^{tm1a(EUCOMM)Wtsi}/Ppp5c^{tm1a(EUCOMM)Wtsi} B6Dnk;B6Brd;B6N-Ppp5c^{tm1a(EUCOMM)Wtsi} Tyr^c-Brd/WtsiH	abnormal behavior	J:175295
	abnormal bone structure	J:175295
	abnormal coat/hair pigmentation	J:175295
	abnormal rib morphology	J:165965, J:175295
	decreased body length	J:165965, J:175295
	decreased body weight	J:165965, J:175295
	decreased circulating cholesterol level	J:175295
	decreased circulating glucose level	J:175295
	decreased circulating HDL cholesterol level	J:175295
	decreased circulating triglyceride level	J:175295
	decreased lumbar vertebrae number	J:165965, J:175295
	decreased mean corpuscular hemoglobin concentration	J:175295
	decreased rib number	J:165965, J:175295
	decreased thoracic vertebrae number	J:165965
	vertebral fusion	J:165965
Ppp5c^{tm1a(EUCOMM)Wtsi}/Ppp5c^{tm1a(EUCOMM)Wtsi} involves: C57BL/6 * C57BL/6N	abnormal rib morphology	J:213427
	caudal vertebral fusion	J:213427
	caudal vertebral transformation	J:213427
	cervical vertebral fusion	J:213427
	decreased body length	J:213427
	decreased body weight	J:213427
	decreased lumbar vertebrae number	J:213427
	decreased respiratory quotient	J:213427
	decreased rib number	J:213427
	decreased thoracic vertebrae number	J:213427
	increased CD4-positive, alpha-beta T cell number	J:213427
	increased CD8-positive, alpha-beta T cell number	J:213427
	increased lymphoma incidence	J:213427
	increased T cell number	J:213427
	lymphoid hyperplasia	J:213427
	truncated ribs	J:213427
	vertebral fusion	J:213427
	vertebral transformation	J:213427
Ppp5c^tm1Lex/Ppp5c^tm1Lex involves: 129S5/SvEvBrd * C57BL/6J	no abnormal phenotype detected	J:103485

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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