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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Runx3
runt related transcription factor 3
MGI:102672
106 phenotypes from 8 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Runx3tm1b(KOMP)Wtsi/Runx3+
C57BL/6N-Runx3tm1b(KOMP)Wtsi/J 		abnormal locomotor behavior J:211773
decreased grip strength J:211773
Runx3tm1b(KOMP)Wtsi/Runx3tm1b(KOMP)Wtsi
C57BL/6N-Runx3tm1b(KOMP)Wtsi/J 		preweaning lethality, complete penetrance J:211773
Runx3tm1Itan/Runx3tm1Itan
Tg(Cd4-cre)1Cwi/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal CD8-positive, alpha beta T cell morphology J:125953
abnormal CD8-positive, alpha-beta T cell differentiation J:125953
decreased CD8-positive, alpha-beta T cell number J:131081
increased IgA level J:125953
lung inflammation J:125953
Runx3tm1Litt/Runx3tm1Litt
involves: 129P2/OlaHsd 		abnormal CD8-positive, alpha-beta T cell differentiation J:141144
abnormal double-positive T cell morphology J:141144
Runx3tm1Yg/Runx3tm1Yg
either: (involves: 129S1/Sv * 129X1/SvJ * BALB/c) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) 		postnatal lethality J:93240
Runx3tm1Yg/Runx3tm1Yg
either: (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1) 		abnormal auchene hair morphology J:99572
abnormal cecum morphology J:93240
abnormal colon morphology J:93240
abnormal crypts of Lieberkuhn morphology J:93240
abnormal cytokine level J:93240
abnormal dendritic cell differentiation J:88424
abnormal dendritic cell morphology J:88424
abnormal dendritic cell physiology J:88424, J:100348
abnormal digestive system physiology J:93240
abnormal dorsal spinal root morphology J:77764
abnormal eating behavior J:93240
abnormal excitatory postsynaptic potential J:77764
abnormal gastric chief cell morphology J:93240
abnormal gastric parietal cell morphology J:93240
abnormal inflammatory response J:93240
abnormal interferon level J:93240
abnormal interleukin level J:93240
abnormal large intestine morphology J:93240
abnormal lung epithelium morphology J:88424
abnormal mesenteric lymph node morphology J:93240
abnormal muscle tone J:77764
abnormal nervous system electrophysiology J:77764
abnormal posture J:77764
abnormal respiratory system physiology J:88424
abnormal sensory neuron innervation pattern J:77764
abnormal sensory neuron morphology J:77764
abnormal spinal cord dorsal column morphology J:77764
abnormal spinal cord dorsal horn morphology J:77764
abnormal stomach mucosa morphology J:93240
abnormal tumor necrosis factor level J:93240
abnormal zigzag hair morphology J:99572
absent Langerhans cell J:88424
absent muscle spindles J:77764
ataxia J:77764
colitis J:93240
decreased body size J:77764
decreased body weight J:93240
decreased spinal cord size J:77764
decreased total body fat amount J:93240
increased airway responsiveness J:100348
increased dendritic cell number J:88424, J:100348
increased IgE level J:100348
intestinal inflammation J:93240
lordosis J:77764
lung inflammation J:88424
postnatal lethality, incomplete penetrance J:77764, J:93240
small dorsal root ganglion J:77764
small intestinal inflammation J:93240
sparse hair J:99572
stomach inflammation J:93240
Runx3tm1Yg/Runx3tm1Yg
involves: 129S1/Sv * 129X1/SvJ 		abnormal CD8-positive, alpha beta T cell morphology J:109584
abnormal muscle tone J:77764
abnormal posture J:77764
ataxia J:77764
decreased body size J:77764
lordosis J:77764
postnatal lethality J:77764
Runx3tm1Yg/Runx3tm1Yg
involves: 129S1/Sv * 129X1/SvJ * ICR 		abnormal bone mineralization J:224290
abnormal clavicle morphology J:224290
abnormal cranium morphology J:224290
abnormal gait J:243559
abnormal intramembranous bone ossification J:224290
abnormal skeleton development J:224290
abnormal skeleton morphology J:224290
abnormal trabecular bone morphology J:224290
ataxia J:243559
decreased body size J:224290
decreased bone mass J:224290
decreased bone mineral content J:224290
decreased bone mineral density J:224290
decreased bone mineral density of femur J:224290
decreased bone stiffness J:224290
decreased bone strength J:224290
decreased bone volume J:224290
decreased compact bone thickness J:224290
decreased diameter of femur J:224290
decreased length of long bones J:224290
decreased osteoblast cell number J:224290
decreased osteoblast proliferation J:224290
decreased skeletal muscle fiber size J:243559
decreased trabecular bone thickness J:224290
decreased trabecular bone volume J:224290
delayed bone ossification J:224290
kyphosis J:224290
scoliosis J:243559
short femur J:224290
short humerus J:224290
normal skeleton phenotype J:243559
small neurocranium J:224290
Runx3tm1Yito/Runx3tm1Yito
involves: 129P2/OlaHsd * C57BL/6 		abnormal stomach epithelium morphology J:75869
decreased circulating glucose level J:75869
increased stomach mucosa thickness J:75869
neonatal lethality, incomplete penetrance J:75869
postnatal lethality, complete penetrance J:75869
stomach mucosa hyperplasia J:75869
Runx3tm2Yg/Runx3tm2Yg
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR 		abnormal CD8-positive, alpha beta T cell morphology J:109584
abnormal dendritic cell differentiation J:109584
normal behavior/neurological phenotype J:109584
Runx3tm3.1Yg/Runx3tm3.1Yg
Not Specified 		abnormal behavior J:224898
abnormal digestive system physiology J:224898
abnormal immune system physiology J:224898
absent Langerhans cell J:224898
ataxia J:224898
decreased body height J:224290
decreased body weight J:224290
decreased bone mineral content J:224290
decreased bone mineral density J:224290
decreased compact bone area J:224290
intestinal inflammation J:224898
short femur J:224290
Runx3tm3Yg/Runx3tm3Yg
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: C57BL/6J * CBA/J 		abnormal gait J:243559
absent proprioceptive neurons J:243559
ataxia J:243559
scoliosis J:243559
Runx3tm3Yg/Runx3tm3Yg
Tg(Col1a1-cre)1Kry/0
involves: FVB/N 		decreased body height J:224290
decreased body mass index J:224290
decreased body size J:224290
decreased body weight J:224290
decreased bone mineral content J:224290
decreased diameter of femur J:224290
decreased femoral compact bone area J:224290
skeleton phenotype J:243559
Runx3tm3Yg/Runx3tm3Yg
Tg(Col2a1-cre)1Bhr/0
involves: C57BL/6 * SJL 		decreased body height J:224290
normal skeleton phenotype J:224290, J:243559
Runx3tm3Yg/Runx3tm3Yg
Tg(Pou4f1-cre/ERT2)2Jiz/0
involves: C57BL/6 		abnormal gait J:243559
abnormal proprioceptive neuron morphology J:243559
ataxia J:243559
scoliosis J:243559
Runx3tm3Yg/Runx3tm3Yg
Tg(Scx-GFP)1Stzr/0
Not Specified 		skeleton phenotype J:243559
Runx3tm3Yg/Runx3tm3Yg
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: CD-1 		decreased body size J:224290
decreased survivor rate J:224290
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory