Runx3 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Runx3
runt related transcription factor 3
MGI:102672

18 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Dynlrb1^{tm1c(EUCOMM)Wtsi}/Dynlrb1^{tm1c(EUCOMM)Wtsi} Runx3^{tm6(EGFP/cre)Yg}/Runx3⁺ involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6N	abnormal gait	J:292124
	abnormal motor coordination/balance	J:292124
	abnormal proprioceptive neuron morphology	J:292124
	decreased locomotor activity	J:292124
	impaired balance	J:292124
	limb grasping	J:292124
	normal nervous system phenotype	J:292124
H2-Ab1^b-tm1Gru/H2-Ab1^b-tm1Gru Runx1^tm1Toku/Runx1^tm1Toku Runx3^tm1Itan/Runx3^tm1Itan Tg(Cd4-cre)1Cwi/0 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2	abnormal interferon secretion	J:131081
	increased CD4-positive, alpha-beta T cell number	J:131081
Runx1^tm1Tani/Runx1^tm1Tani Runx3^tm1Itan/Runx3^tm1Itan Tg(Cd4-cre)1Cwi/? involves: 129P2/OlaHsd * C57BL/6 * DBA/2	decreased CD8-positive, alpha-beta T cell number	J:125959
Runx1^tm1Toku/Runx1⁺ Runx3^tm1Itan/Runx3^tm1Itan Tg(Cd4-cre)1Cwi/0 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	decreased CD8-positive, alpha-beta T cell number	J:131081
Runx1^tm1Toku/Runx1^tm1Toku Runx3^tm1Itan/Runx3⁺ Tg(Cd4-cre)1Cwi/0 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	decreased CD4-positive, alpha-beta T cell number	J:131081
	decreased CD8-positive, alpha-beta T cell number	J:131081
Runx1^tm1Toku/Runx1^tm1Toku Runx3^tm1Itan/Runx3^tm1Itan Tg(Cd4-cre)1Cwi/0 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	decreased CD4-positive, alpha-beta T cell number	J:131081
	decreased CD8-positive, alpha-beta T cell number	J:131081
Runx2^tm1Mjo/Runx2⁺ Runx3^tm1Yg/Runx3^tm1Yg involves: 129S1/Sv * 129X1/SvJ * ICR	delayed bone ossification	J:224290
	postnatal lethality, incomplete penetrance	J:224290
Runx2^tm1Mjo/Runx2⁺ Runx3^tm3Yg/Runx3^tm3Yg Tg(Col1a1-cre)1Kry/0 involves: FVB/N	decreased body height	J:224290
	decreased body size	J:224290
Runx3^tm1.1Itok/Runx3^tm1.1Itok Trp53^tm1Brn/Trp53^tm1Brn Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 involves: 129P2/OlaHsd * C57BL/6 * CD-1	decreased osteosarcoma incidence	J:319454
	increased tumor-free survival time	J:319454
Runx3^tm1Itan/Runx3⁺ Trp53^tm1Brn/Trp53^tm1Brn Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 involves: 129P2/OlaHsd * C57BL/6 * CD-1	decreased osteosarcoma incidence	J:319454
	increased tumor-free survival time	J:319454
Runx3^tm1Itan/Runx3^tm1Itan Trp53^tm1Brn/Trp53^tm1Brn Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 involves: 129P2/OlaHsd * C57BL/6 * CD-1	premature death	J:319454

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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