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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lhx3
LIM homeobox protein 3
MGI:102673
54 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Lhx3tm1(cre)Slp/Lhx3tm1(cre)Slp
involves: 129S1/Sv 		abnormal Rathke's pouch apoptosis J:119270
abnormal Rathke's pouch development J:119270
absent adenohypophysis J:119270
small pituitary intermediate lobe J:119270
Lhx3tm1.1Sjr/Lhx3tm1.1Sjr
involves: 129S/SvEv * C57BL/6J * FVB/N 		abnormal craniofacial morphology J:169035
abnormal fertility/fecundity J:169035
abnormal internal male genitalia morphology J:169035
abnormal pituitary gland morphology J:169035
abnormal pituitary hormone level J:169035
abnormal sex gland secretion J:169035
abnormal spermatogenesis J:169035
abnormal thyroid follicle morphology J:169035
abnormal uterus development J:169035
abnormal uterus morphology J:169035
adenohypophysis hypoplasia J:169035
azoospermia J:169035
cachexia J:169035
decreased activity of thyroid gland J:169035
decreased adrenocorticotropin level J:169035
decreased body size J:169035
decreased circulating insulin-like growth factor I level J:169035
decreased circulating prolactin level J:169035
decreased circulating thyroxine level J:169035
decreased follicle stimulating hormone level J:169035
decreased gonadotroph cell number J:169035
decreased lactotroph cell number J:169035
decreased luteinizing hormone level J:169035
decreased prolactin level J:169035
decreased survivor rate J:169035
decreased uterus weight J:169035
delayed sexual maturation J:169035
normal endocrine/exocrine gland phenotype J:169035
female infertility J:169035
normal hearing/vestibular/ear phenotype J:169035
perinatal lethality, incomplete penetrance J:169035
postnatal growth retardation J:169035
premature death J:169035
reduced male fertility J:169035
normal reproductive system phenotype J:169035
small prostate gland J:169035
small seminal vesicle J:169035
small testis J:169035
small uterus J:169035
Lhx3tm1Lmgd/Lhx3tm1Lmgd
involves: 129S4/SvJae 		abnormal corticotroph morphology J:33050
abnormal pituitary gland development J:33050
abnormal Rathke's pouch development J:33050
absent adenohypophysis J:33050, J:51420
absent lactotrophs J:33050
absent pituitary intermediate lobe J:33050, J:51420
absent somatotrophs J:33050
absent thyrotrophs J:33050
adrenal cortical hyperplasia J:33050
decreased adrenocorticotropin level J:33050
decreased gonadotroph cell number J:33050
decreased growth hormone level J:33050
decreased luteinizing hormone level J:33050
decreased thyroid-stimulating hormone level J:33050
normal nervous system phenotype J:51420
prenatal lethality, complete penetrance J:33050
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory