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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Umod
uromodulin
MGI:102674
98 phenotypes from 8 alleles in 10 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Tg(Umod)416Lura/0
involves: FVB 		no abnormal phenotype detected J:161532
Tg(Umod*C147W)958Lura/0
involves: FVB 		abnormal kidney morphology J:161532
abnormal renal tubule morphology J:161532
abnormal renal/urinary system physiology J:161532
decreased urine osmolality J:161532
decreased urine pH J:161532
dilated renal tubule J:161532
increased blood osmolality J:161532
increased blood urea nitrogen level J:161532
increased circulating antidiuretic hormone level J:161532
increased circulating creatinine level J:161532
increased kidney cell proliferation J:161532
increased urine calcium level J:161532
isosthenuria J:161532
kidney corticomedullary cyst J:161532
kidney failure J:161532
kidney inflammation J:161532
polydipsia J:161532
polyuria J:161532
renal cast J:161532
renal interstitial fibrosis J:161532
renal tubular necrosis J:161532
renal tubule atrophy J:161532
Umodem1Duf/Umod+
C57BL/6J-Umodem1Duf 		abnormal autophagy J:252597
abnormal proximal convoluted tubule morphology J:252597
decreased body weight J:252597
decreased kidney weight J:252597
increased blood urea nitrogen level J:252597
increased circulating creatinine level J:252597
increased endoplasmic reticulum stress J:252597
increased kidney apoptosis J:252597
isosthenuria J:252597
kidney failure J:252597
kidney inflammation J:252597
renal interstitial fibrosis J:252597
Umodtm1.1Rvt/Umod+
either: B6J.129-Umodtm1.1Rvt or (involves: 129S1/Sv * 129X1/SvJ) 		decreased urine osmolality J:242593
decreased urine pH J:242593
decreased urine protein level J:242593
decreased urine uric acid level J:242593
increased blood osmolality J:242593
increased blood urea nitrogen level J:242593
increased circulating creatinine level J:242593
increased urine calcium level J:242593
kidney failure J:242593
kidney inflammation J:242593
polyuria J:242593
renal interstitial fibrosis J:242593
Umodtm1.1Rvt/Umodtm1.1Rvt
either: B6J.129-Umodtm1.1Rvt or (involves: 129S1/Sv * 129X1/SvJ) 		abnormal renal tubule morphology J:242593
decreased urine osmolality J:242593
decreased urine pH J:242593
decreased urine protein level J:242593
decreased urine uric acid level J:242593
glomerulosclerosis J:242593
increased alkaline phosphatase activity J:242593
increased blood osmolality J:242593
increased blood urea nitrogen level J:242593
increased circulating calcium level J:242593
increased circulating creatinine level J:242593
increased urine calcium level J:242593
kidney failure J:242593
kidney inflammation J:242593
polyuria J:242593
renal interstitial fibrosis J:242593
Umodtm1Kuma/Umodtm1Kuma
involves: 129 		abnormal juxtaglomerular apparatus morphology J:96653
abnormal kidney morphology J:245853
abnormal loop of Henle ascending limb thick segment morphology J:96653
abnormal urine homeostasis J:245853
abnormal urine osmolality J:96653
decreased creatinine clearance J:96653, J:245853
decreased renal glomerular filtration rate J:96653, J:245853
decreased susceptibility to hypertension J:245853
decreased systemic arterial systolic blood pressure J:245853
increased creatinine clearance J:245853
increased fluid intake J:245853
increased renal glomerular filtration rate J:245853
increased urine chloride ion level J:245853
increased urine potassium level J:245853
increased urine sodium level J:245853
polyuria J:96653, J:245853
weight loss J:245853
Umodtm1Xrw/Umod+
B6.129S6-Umodtm1Xrw 		hydronephrosis J:163552
nephrocalcinosis J:163552
urolithiasis J:163552
Umodtm1Xrw/Umodtm1Xrw
129S/SvEv-Umodtm1Xrw 		abnormal kidney papilla morphology J:163552
abnormal papillary duct morphology J:163552
abnormal urine homeostasis J:127526, J:163552
abnormal urine organic anion level J:163552
crystalluria J:127526
decreased urine citrate level J:163552
decreased urine flow rate J:163552
decreased urine pH J:163552
dilated kidney collecting duct J:127526, J:163552
hydronephrosis J:163552
increased urine ammonia level J:163552
increased urine calcium level J:163552
increased urine chloride ion level J:127526, J:163552
increased urine creatinine level J:163552
increased urine magnesium level J:163552
increased urine phosphate level J:127526, J:163552
increased urine potassium level J:163552
increased urine sodium level J:127526
increased urine uric acid level J:163552
nephrocalcinosis J:127526, J:163552
renal fibrosis J:127526
urolithiasis J:163552
Umodtm1Xrw/Umodtm1Xrw
B6.129S6-Umodtm1Xrw 		abnormal kidney papilla morphology J:163552
abnormal papillary duct morphology J:163552
dilated kidney collecting duct J:163552
hydronephrosis J:163552
nephrocalcinosis J:163552
urolithiasis J:163552
Umodtm1Xrw/Umodtm1Xrw
involves: 129S6/SvEvTac 		increased susceptibility to bacterial infection J:95431
UmodUrehd1/Umod+
C3HeB/FeJ-UmodUrehd1 		decreased body weight J:121470
decreased circulating glucose level J:121470
decreased renal glomerular filtration rate J:121470
decreased total body fat amount J:121470
decreased urine creatinine level J:121470
decreased urine sodium level J:121470
increased blood urea nitrogen level J:121470
increased circulating creatinine level J:121470
increased fluid intake J:121470
increased food intake J:121470
increased urine potassium level J:121470
polyuria J:121470
UmodUrehd1/Umod+
involves: C3HeB/FeJ 		abnormal endoplasmic reticulum morphology J:201084
abnormal loop of Henle ascending limb thick segment morphology J:201084
abnormal urine urea nitrogen level J:201084
decreased body weight J:201084
decreased bone mineral content J:201084
decreased bone mineral density J:201084
decreased circulating cholesterol level J:201084
decreased circulating ferritin level J:201084
decreased circulating iron level J:201084
decreased circulating phosphate level J:201084
decreased circulating transferrin level J:201084
decreased circulating triglyceride level J:201084
decreased total body fat amount J:201084
decreased urine osmolality J:201084
decreased urine uric acid level J:201084
dilated renal glomerular capsule J:201084
normal homeostasis/metabolism phenotype J:201084
hydronephrosis J:201084
increased blood urea nitrogen level J:201084
increased circulating alkaline phosphatase level J:201084
increased circulating calcium level J:201084
increased circulating creatinine level J:201084
increased circulating potassium level J:201084
increased urine calcium level J:201084
increased urine chloride ion level J:201084
increased urine flow rate J:201084
increased urine magnesium level J:201084
increased urine potassium level J:201084
increased urine sodium level J:201084
renal glomerulus cyst J:201084
renal interstitial fibrosis J:201084
renal tubular necrosis J:201084
UmodUrehd1/UmodUrehd1
involves: C3HeB/FeJ 		decreased body weight J:201084
decreased renal glomerular filtration rate J:201084
increased blood urea nitrogen level J:201084
renal interstitial fibrosis J:201084
renal tubular necrosis J:201084
Umodurehr4/Umod+
C3HeB/FeJ-Umodurehr4 		abnormal blood homeostasis J:153895
abnormal circulating lipid level J:153895
decreased basal metabolism J:153895
decreased body temperature J:153895
decreased body weight J:153895
decreased bone mineral content J:153895
decreased bone mineral density J:153895
decreased circulating cholesterol level J:153895
decreased circulating triglyceride level J:153895
decreased percent body fat/body weight J:153895
decreased total body fat amount J:153895
increased blood urea nitrogen level J:201084
increased circulating creatinine level J:153895
increased lean body mass J:153895
renal interstitial fibrosis J:201084
renal tubular necrosis J:201084
Umodurehr4/Umodurehr4
C3HeB/FeJ-Umodurehr4 		abnormal blood homeostasis J:153895
abnormal bone structure J:153895
abnormal circulating lipid level J:153895
abnormal urine homeostasis J:153895
decreased basal metabolism J:153895
decreased body temperature J:153895
decreased body weight J:153895
decreased bone mineral content J:153895
decreased bone mineral density J:153895
decreased bone mineral density of femur J:153895
decreased circulating cholesterol level J:153895
decreased circulating triglyceride level J:153895
decreased percent body fat/body weight J:153895
decreased total body fat amount J:153895
decreased urine osmolality J:153895
decreased urine sodium level J:121470
increased blood urea nitrogen level J:121470
increased blood uric acid level J:153895
increased circulating calcium level J:153895
increased circulating creatinine level J:121470, J:153895
increased lean body mass J:153895
increased urine potassium level J:153895
increased urine sodium level J:153895
polyuria J:153895
normal renal/urinary system phenotype J:153895
uremia J:153895
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory