H2ax Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

H2ax
H2A.X variant histone
MGI:102688

20 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
H2ax^tm1Fwa/H2ax⁺ involves: 129S6/SvEvTac	chromosomal instability	J:84879
H2ax^tm1Fwa/H2ax^tm1Fwa involves: 129S6/SvEvTac	abnormal class switch recombination	J:84879
	chromosomal instability	J:84879
	decreased body size	J:84879
	decreased lymphocyte cell number	J:84879
	increased T cell derived lymphoma incidence	J:84879
H2ax^tm1Nus/H2ax^tm1Nus Not Specified	abnormal class switch recombination	J:120658, J:194603
	abnormal physiological neovascularization	J:149487
	abnormal tumor vascularization	J:149487
	arrest of male meiosis	J:76360
	decreased B cell number	J:76360
	decreased cell proliferation	J:76360, J:149487
	decreased IgG level	J:73342
	decreased T cell number	J:76360
	decreased tumor growth/size	J:149487
	decreased vascular endothelial cell proliferation	J:194603
	increased mortality induced by gamma-irradiation	J:76360
	increased vascular endothelial cell apoptosis	J:149487
	postnatal growth retardation	J:76360
	retina neovascularization	J:149487
	small seminiferous tubules	J:76360
	small testis	J:76360
H2ax^tm1Nus/H2ax^tm2.1Fwa Tg(Cdh5-cre)7Mlia/0 involves: 129S6/SvEvTac * FVB/N	abnormal tumor vascularization	J:149487
	decreased tumor growth/size	J:149487
	retina neovascularization	J:149487

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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