H2ax Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

H2ax
H2A.X variant histone
MGI:102688

14 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Atm^tm1Fwa/Atm^tm1Fwa H2ax^tm1Fwa/H2ax^tm1Fwa involves: 129S4/SvJae * 129S6/SvEvTac	chromosomal instability	J:138190
	embryonic lethality during organogenesis, complete penetrance	J:138190
	increased cell death	J:138190
	spontaneous chromosome breakage	J:138190
H2ax^tm1Fwa/H2ax⁺ Trp53^tm1Brd/Trp53^tm1Brd involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6	increased B cell derived lymphoma incidence	J:84879
	increased lymphoma incidence	J:84879
	increased sarcoma incidence	J:84879
	increased T cell derived lymphoma incidence	J:84879
	increased teratoma incidence	J:84879
	premature death	J:84879
H2ax^tm1Fwa/H2ax^tm1Fwa Trp53^tm1Brd/Trp53^tm1Brd involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6	increased B cell derived lymphoma incidence	J:84879
	increased colon adenocarcinoma incidence	J:84879
	increased sarcoma incidence	J:84879
	increased T cell derived lymphoma incidence	J:84879
	increased tumor incidence	J:84879
	premature death	J:84879
H2ax^tm1Nus/H2ax⁺ Trp53^tm1Brd/Trp53^tm1Brd involves: 129S7/SvEvBrd * C57BL/6J	increased incidence of induced tumors	J:86590
	premature death	J:86590
H2ax^tm1Nus/H2ax^tm1Nus Igh^tm1Mnz/Igh^tm1Mnz involves: 129P2/OlaHsd	normal immune system phenotype	J:120658
H2ax^tm1Nus/H2ax^tm1Nus Igh^tm2Mnz/Igh^tm2Mnz involves: 129P2/OlaHsd	normal immune system phenotype	J:120658
H2ax^tm1Nus/H2ax^tm1Nus Trp53^tm1Brd/Trp53^tm1Brd involves: 129S7/SvEvBrd * C57BL/6J	increased lymphoma incidence	J:86590
	premature death	J:86590

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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