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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Itga7
integrin alpha 7
MGI:102700
31 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Itga6tm2Egl/Itga6tm2Egl
Itga7tm1Umr/Itga7tm1Umr
Tg(Mpz-cre)26Mes/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac 		abnormal axon radial sorting J:204174
abnormal myelination J:204174
abnormal Schwann cell physiology J:204174
abnormal sciatic nerve morphology J:204174
axon degeneration J:204174
hypermyelination J:204174
Itga7tm1Burk/Itga7tm1Burk
Sspntm1Kcam/Sspntm1Kcam
involves: 129S1/Sv * 129X1/SvJ 		abnormal diaphragm morphology J:187752
abnormal muscle physiology J:187752
abnormal quadriceps morphology J:187752
abnormal sarcolemma morphology J:187752
abnormal skeletal muscle fiber type ratio J:187752
centrally nucleated skeletal muscle fibers J:187752
decreased body weight J:187752
decreased quadriceps weight J:187752
decreased skeletal muscle mass J:187752
enhanced skeletal muscle regeneration J:187752
increased susceptibility to injury J:187752
kyphosis J:187752
myopathy J:187752
premature death J:187752
skeletal muscle atrophy J:187752
skeletal muscle fibrosis J:187752
Itga7tm1Umr/Itga7tm1Umr
Sgcgtm1Mcn/Sgcgtm1Mcn
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cell physiology J:91880
abnormal gait J:91880
abnormal stationary movement J:91880
decreased grooming behavior J:91880
increased apoptosis J:91880
kyphoscoliosis J:91880
lethality at weaning, complete penetrance J:91880
muscle degeneration J:91880
postnatal growth retardation J:91880
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory