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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cav1
caveolin 1, caveolae protein
MGI:102709
205 phenotypes from 7 alleles in 14 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cav1em2(IMPC)Ics/Cav1em2(IMPC)Ics
C57BL/6N-Cav1em2(IMPC)Ics/Ics 		decreased cardiac muscle contractility J:211773
decreased grip strength J:211773
increased circulating cholesterol level J:211773
increased circulating HDL cholesterol level J:211773
increased heart rate J:211773
increased hemoglobin content J:211773
increased mean corpuscular hemoglobin J:211773
increased mean corpuscular volume J:211773
Cav1tm1.1Aia/Cav1tm1.1Aia
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal uterus physiology J:174719
enlarged endometrial glands J:174719
increased endometrial gland number J:174719
normal neoplasm J:174719
ovary cyst J:174719
normal reproductive system phenotype J:174719
uterus cyst J:174719
Cav1tm1Krc/Cav1tm1Krc
involves: 129S4/SvJae * Black Swiss 		abnormal nitric oxide homeostasis J:78603
absent caveolae J:78603
decreased heart left ventricle posterior wall thickness J:78603
decreased heart ventricle muscle contractility J:78603
dilated cardiomyopathy J:78603
dilated heart left ventricle J:78603
dilated heart right ventricle J:78603
heart right ventricle hypertrophy J:78603
increased heart left ventricle weight J:78603
increased heart right ventricle muscle contractility J:78603
pulmonary hypertension J:78603
thin interventricular septum J:78603
Cav1tm1Kur/Cav1tm1Kur
involves: 129X1/SvJ 		abnormal thyroid follicular cell morphology J:119709
Cav1tm1Kur/Cav1tm1Kur
involves: 129X1/SvJ * C57BL/6 		abnormal lipid level J:112452
abnormal liver physiology J:112452
abnormal type II pneumocyte morphology J:71760
abnormal vasoconstriction J:71760
absent caveolae J:71760
normal cellular phenotype J:71760
decreased hepatocyte proliferation J:112452
decreased liver triglyceride level J:112452
normal homeostasis/metabolism phenotype J:71760
impaired exercise endurance J:71760
impaired liver regeneration J:112452
increased lung endothelial cell proliferation J:71760
increased susceptibility to induced morbidity/mortality J:112452
increased vasodilation J:71760
pulmonary interstitial fibrosis J:71760
thick pulmonary interalveolar septum J:71760
Cav1tm1Mls/Cav1tm1Mls
B6.Cg-Cav1tm1Mls 		abnormal brown fat cell morphology J:105133
abnormal fat cell morphology J:205741
abnormal lactation J:120010
abnormal lung vasculature morphology J:205741
abnormal mammary gland growth during pregnancy J:120010
abnormal triglyceride level J:105133
abnormal vascular endothelial cell morphology J:205741
absent caveolae J:205741
decreased core body temperature J:105133
decreased fatty acids level J:105133
impaired adaptive thermogenesis J:105133
impaired lipolysis J:105133
increased brown fat cell lipid droplet size J:105133
Cav1tm1Mls/Cav1tm1Mls
B6.Cg-Cav1tm1Mls/J 		abnormal lung morphology J:143600
abnormal pulmonary elastic fiber morphology J:143600
abnormal respiratory mechanics J:143600
absent caveolae J:143600
decreased lung compliance J:143600
increased airway resistance J:143600
increased lung elastance J:143600
increased vascular permeability J:143600
pulmonary edema J:143600
reduced fertility J:143600
Cav1tm1Mls/Cav1tm1Mls
FVB.Cg-Cav1tm1Mls 		abnormal adipose tissue physiology J:182288
abnormal cellular respiration J:182288
abnormal circulating amino acid level J:182288
abnormal free fatty acids level J:182288
abnormal glucose homeostasis J:182288
abnormal homeostasis J:182288
abnormal liver physiology J:182288
abnormal respiratory electron transport chain J:182288
abnormal respiratory quotient J:182288
abnormal skeletal muscle morphology J:182288
decreased circulating adiponectin level J:182288
decreased liver glycogen level J:182288
decreased susceptibility to diet-induced hepatic steatosis J:182288
decreased susceptibility to diet-induced obesity J:182288
decreased total body fat amount J:182288
enhanced gluconeogenesis J:182288
enhanced lipolysis J:182288
hyperglycemia J:182288
increased blood urea nitrogen level J:182288
increased circulating glycerol level J:182288
increased circulating insulin level J:182288
increased food intake J:182288
increased liver glycogen level J:182288
increased liver weight J:182288
increased oxygen consumption J:182288
increased respiratory quotient J:182288
increased triglyceride level J:182288
insulin resistance J:182288
weight loss J:182288
Cav1tm1Mls/Cav1tm1Mls
involves: 129/Sv * C57BL/6 * FVB/N * SJL 		abnormal mammary gland morphology J:147439
increased mammary gland tumor incidence J:147439
Cav1tm1Mls/Cav1tm1Mls
involves: 129/Sv * C57BL/6 * SJL 		abnormal blood homeostasis J:75192
abnormal bone mineralization J:141361
abnormal bone trabecula morphology J:141361
abnormal chemokine secretion J:115914
abnormal circulating free fatty acids level J:75192
abnormal compact bone morphology J:141361
abnormal cytokine level J:115914
abnormal fat cell morphology J:75192
abnormal gonadal fat pad morphology J:75192
abnormal homeostasis J:116286
abnormal lipid homeostasis J:75192
abnormal long bone epiphysis morphology J:141361
abnormal long bone metaphysis morphology J:141361
abnormal macrophage physiology J:115914
abnormal mammary fat pad morphology J:75192
abnormal mammary gland duct morphology J:75192
abnormal mammary gland epithelium morphology J:109251
abnormal mammary gland morphology J:75192
abnormal myocardium layer morphology J:87282
abnormal neutrophil physiology J:139304
abnormal nitric oxide homeostasis J:139304
abnormal osteoclast morphology J:141361
abnormal pulmonary alveolar parenchyma morphology J:75193
abnormal pulmonary endothelial cell surface J:87282
abnormal skeletal muscle fiber morphology J:117199
abnormal vasoconstriction J:75193
abnormal vasodilation J:75193
abnormal vesicle-mediated transport J:73489
absent caveolae J:73489, J:75192, J:75193
absent subcutaneous adipose tissue J:75192
cardiac fibrosis J:87282
cardiac hypertrophy J:87282
congestive heart failure J:87282
decreased body weight J:75192
decreased cardiac muscle contractility J:87282
decreased circulating leptin level J:75192
decreased subcutaneous adipose tissue amount J:75192
decreased susceptibility to diet-induced obesity J:75192
decreased susceptibility to endotoxin shock J:139304
decreased total body fat amount J:75192
decreased white adipose tissue amount J:75192
decreased white fat cell lipid droplet size J:75192
dilated heart right ventricle J:87282
epidermal hyperplasia J:83485
heart left ventricle hypertrophy J:87282
normal homeostasis/metabolism phenotype J:75192
impaired exercise endurance J:75193
impaired neutrophil recruitment J:115914
increased bone strength J:141361
increased bone trabecula number J:141361
increased brown adipose tissue amount J:75192
increased cerebral infarct size J:133702
increased circulating CXCL10 level J:115914
increased circulating interferon-gamma level J:115914
increased circulating interleukin-6 level J:115914
increased circulating triglyceride level J:75192
increased circulating tumor necrosis factor level J:115914
increased circulating VLDL triglyceride level J:75192
increased femoral compact bone area J:141361
increased food intake J:75192
increased heart left ventricle wall thickness J:87282
increased incidence of tumors by chemical induction J:83485
increased susceptibility to bacterial infection J:115914
increased susceptibility to bacterial infection induced morbidity/mortality J:115914
increased trabecular bone thickness J:141361
normal liver/biliary system phenotype J:75192
lung inflammation J:87282
mammary gland duct hyperplasia J:109251
mammary gland hyperplasia J:109251
myocardial fiber disarray J:87282
normal neoplasm J:109251
premature bone ossification J:141361
premature death J:87282
pulmonary hyperemia J:87282
pulmonary hypertension J:87282
slow postnatal weight gain J:75192
thick interventricular septum J:87282
thick pulmonary interalveolar septum J:75193, J:87282
Cav1tm1Mls/Cav1tm1Mls
involves: 129/Sv * C57BL/6J * SJL 		abnormal actin cytoskeleton morphology J:134719
abnormal brain internal capsule morphology J:110712
abnormal cell morphology J:134719
abnormal cellular cholesterol metabolism J:116292
abnormal chondrocyte physiology J:128103
abnormal costochondral joint morphology J:128103
abnormal digestive system physiology J:114334
abnormal fat cell morphology J:89326
abnormal fibroblast chemotaxis J:134719
abnormal gait J:110712
abnormal hyaline cartilage morphology J:128103
abnormal involuntary movement J:110712
abnormal locomotor behavior J:110712
abnormal long bone epiphyseal plate morphology J:128103
abnormal long bone epiphyseal plate proliferative zone J:128103
abnormal long bone hypertrophic chondrocyte zone J:128103
abnormal long bone metaphysis morphology J:128103
abnormal microtubule organizing center morphology J:134719
abnormal nitric oxide homeostasis J:114334
abnormal trabecular bone morphology J:128103
abnormal vascular endothelial cell morphology J:79595
abnormal vascular wound healing J:115492
absent caveolae J:114334, J:115492, J:128103
decreased body weight J:84260
decreased brain size J:110712
decreased brain weight J:110712
decreased exploration in new environment J:110712
decreased fibroblast chemotaxis J:134719
decreased grip strength J:110712
decreased locomotor activity J:110712
decreased vasoconstriction J:120603
impaired lipolysis J:89326
impaired wound healing J:134719
increased circulating insulin level J:84260
increased long bone epiphyseal plate size J:128103
increased vascular permeability J:79595
insulin resistance J:84260
limb grasping J:110712
short stride length J:110712
Cav1tm1Mls/Cav1tm1Mls
Not Specified 		abnormal astrocyte morphology J:168335
abnormal brain vasculature morphology J:168335
abnormal cell cytoskeleton morphology J:168335
abnormal CNS glial cell morphology J:168335
abnormal dendrite morphology J:168335
abnormal dentate gyrus morphology J:168335
abnormal hippocampus CA1 region morphology J:168335
amyloid beta deposits J:168335
astrocytosis J:168335
brain ischemia J:168335
decreased CNS synapse formation J:168335
hippocampal neuron degeneration J:168335
tau protein deposits J:168335
Cav1tm1Mls/Cav1tm1Mls
STOCK Cav1tm1Mls/J 		abnormal thyroid follicular cell morphology J:119709
decreased body weight J:132392
decreased vasoconstriction J:132392
increased systemic arterial blood pressure J:132392
increased vasodilation J:132392
Cav1tm1Pesch/Cav1tm1Pesch
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
FVB.Cg-Cav1tm1Pesch Speer6-ps1Tg(Alb-cre)21Mgn 		decreased circulating glucose level J:182288
decreased circulating glycerol level J:182288
normal liver/biliary system phenotype J:182288
Cav1tm1Tt/Cav1tm1Tt
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal renal calcium reabsorption J:82490
increased kidney weight J:82490
increased urine calcium level J:82490
normal renal/urinary system phenotype J:82490
urolithiasis J:82490
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory