Cav1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cav1
caveolin 1, caveolae protein
MGI:102709

33 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apoe^tm1Unc/Apoe^tm1Unc Cav1^tm1Mls/Cav1^tm1Mls involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * SJL	decreased susceptibility to atherosclerosis	J:101788
	increased circulating cholesterol level	J:101788
	increased circulating LDL cholesterol level	J:101788
	increased circulating triglyceride level	J:101788
	increased circulating VLDL cholesterol level	J:101788
Cav1^tm1.1Aia/Cav1^tm1.1Aia crsp/+ involves: 129S7/SvEvBrd * C57BL/6J * FVB	enlarged endometrial glands	J:174719
	increased endometrial gland number	J:174719
	normal neoplasm	J:174719
	ovary cyst	J:174719
	normal reproductive system phenotype	J:174719
	uterus cyst	J:174719
Cav1^tm1.1Aia/Cav1^tm1.1Aia crsp/crsp involves: 129S7/SvEvBrd * C57BL/6J * FVB	enlarged endometrial glands	J:174719
	increased endometrial gland number	J:174719
	normal neoplasm	J:174719
	ovary cyst	J:174719
	uterus cyst	J:174719
Cav1^tm1.1Aia/Cav1^tm1.1Aia Rxfp2^tm1Aia/Rxfp2⁺ involves: 129S7/SvEvBrd * C57BL/6J * FVB	abnormal uterus physiology	J:174719
	enlarged endometrial glands	J:174719
	increased endometrial gland number	J:174719
	normal neoplasm	J:174719
	ovary cyst	J:174719
	normal reproductive system phenotype	J:174719
	uterus cyst	J:174719
Cav1^tm1Mls/Cav1⁺ Tg(MMTV-PyVT)634Mul/0 involves: 129/Sv * C57BL/6J * FVB/N * SJL	increased mammary gland tumor incidence	J:132472
Cav1^tm1Mls/Cav1^tm1Mls Cav3^tm1Mls/Cav3^tm1Mls involves: 129/Sv * C57BL/6J * SJL	abnormal myocardial fiber morphology	J:77372
	absent caveolae	J:77372
	cardiac hypertrophy	J:77372
	cardiac interstitial fibrosis	J:77372
	cardiomyopathy	J:77372
	decreased heart left ventricle muscle contractility	J:77372
	dilated heart left ventricle	J:77372
	heart inflammation	J:77372
	heart left ventricle hypertrophy	J:77372
	increased heart left ventricle wall thickness	J:77372
	increased heart right ventricle wall thickness	J:77372
	increased heart weight	J:77372
	myocardial fiber disarray	J:77372
	thick interventricular septum	J:77372
Cav1^tm1Mls/Cav1^tm1Mls Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp involves: 129/Sv * C57BL/6 * SJL	abnormal branching of the mammary ductal tree	J:90334
	abnormal cell cycle	J:90334
	abnormal mammary gland duct morphology	J:90334
	increased fibroblast proliferation	J:90334
	mammary gland duct hyperplasia	J:90334
Cav1^tm1Mls/Cav1^tm1Mls Tg(MMTV-PyVT)634Mul/0 involves: 129/Sv * C57BL/6J * FVB/N * SJL	increased mammary gland tumor incidence	J:132472
Cav1^tm1Mls/Cav1^tm1Mls Tg(TRAMP)8247Ng/0 involves: 129/Sv * C57BL/6 * SJL	decreased tumor incidence	J:133066

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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