Ednrb Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ednrb
endothelin receptor type B
MGI:102720

59 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
A^y/a Ednrb^s/Ednrb^s Not Specified	variable body spotting	J:12954
Ednra^tm1Ywa/Ednra^tm1Ywa Ednrb^tm1Ywa/Ednrb^tm1Ywa involves: 129S7/SvEvBrd	abnormal artery morphology	J:46640
	pericardial effusion	J:46640
	prenatal lethality	J:46640
Ednrb^s-3CHLo/Ednrb^s-3CHLo involves: 101/Rl * C3H/Rl	megacolon	J:44601, J:100221
	postnatal lethality, complete penetrance	J:44601, J:100221
	white spotting	J:44601, J:100221
Ednrb^s-15DttMb/Ednrb⁺ Mycbp2^tm1.1Adia/Mycbp2⁺ involves: 101/Rl * C3H/Rl * C57BL/6 * FVB/N	abnormal nervous system morphology	J:125702
Ednrb^s-24Pub/Ednrb⁺ Mycbp2^m274-4Tpo/Mycbp2⁺ involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ	neonatal lethality, complete penetrance	J:149893
	respiratory distress	J:149893
Ednrb^s-24Pub/Ednrb⁺ m128-7Tpo/m128-7Tpo⁺ involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ	abnormal direction of heart looping	J:149893
	abnormal head morphology	J:149893
	abnormal pharyngeal arch morphology	J:149893
	abnormal vitelline vasculature morphology	J:149893
	embryonic lethality, complete penetrance	J:149893
	enlarged pericardium	J:149893
	hemopericardium	J:149893
	incomplete embryo turning	J:149893
Ednrb^s-24Pub/Ednrb⁺ m174-16Tpo/m174-16Tpo⁺ involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ	lethality throughout fetal growth and development, complete penetrance	J:149893
Ednrb^s-24Pub/Ednrb⁺ m183-15Tpo/m183-15Tpo⁺ involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ	embryonic lethality between implantation and somite formation, complete penetrance	J:149893
Ednrb^s-24Pub/Ednrb⁺ m251-2Tpo/m251-2Tpo⁺ involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ	preweaning lethality, complete penetrance	J:149893
Ednrb^s-24Pub/Ednrb⁺ m283-1Tpo/m283-1Tpo⁺ involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ	preweaning lethality, complete penetrance	J:149893
Ednrb^s-24Pub/Ednrb^s-24Pub m289-5Tpo/m289-5Tpo⁺ involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ	preweaning lethality, complete penetrance	J:149893
Ednrb^s-31Pub/Ednrb⁺ involves: 101/Rl * C3H/Rl	decreased body size	J:100221
Ednrb^s-31Pub/Ednrb^s-31Pub involves: 101/Rl * C3H/Rl	prenatal lethality, complete penetrance	J:100221
Ednrb^s-36Pub/Ednrb⁺ Spry2^tm1.1Mrt/Spry2⁺ involves: 101/Rl * 129P2/OlaHsd * C3H/Rl * C57BL/6J	abnormal palatal rugae morphology	J:125229
	cleft secondary palate	J:125229
Ednrb^s-36Pub/Ednrb^s-36Pub Tg(Spry2)2Tpo/0 B6.Cg-Ednrb^s-36Pub Tg(Spry2)2Tpo	abnormal palate bone morphology	J:125229
	cleft secondary palate	J:125229
	normal craniofacial phenotype	J:125229
	maxillary shelf hypoplasia	J:125229
Ednrb^s-36Pub/Ednrb^s-36Pub Tg(Spry2)69Tpo/0 B6.Cg-Ednrb^s-36Pub Tg(Spry2)69Tpo	abnormal palate bone morphology	J:125229
	cleft secondary palate	J:125229
	normal craniofacial phenotype	J:125229
	maxillary shelf hypoplasia	J:125229
Ednrb^s/Ednrb^s-3CHLo involves: 101/Rl * C3H/Rl	white spotting	J:100221
Ednrb^s/Ednrb^s-31Pub involves: 101/Rl * C3H/Rl	decreased body size	J:100221
Ednrb^s/Ednrb^s-31Pub involves: 101/Rl * C3H/Rl	white spotting	J:100221
Ednrb^s/Ednrb^s Lyst^bg-slt/Lyst^bg-slt involves: C57BL/10Ch * Y257/Ch	abnormal eye pigmentation	J:25388
Ednrb^s/Ednrb^s Mc1r^e/Mc1r^e Not Specified	white spotting	J:5110
Ednrb^s/Ednrb^s Mc1r^e/Mc1r^e Not Specified	yellow coat color	J:5110
Ednrb^tm1.1Nat/Ednrb^tm1.2Nat Igs1^{tm11(CAG-Bgeo,-Edn2)Nat}/Igs1⁺ Tg(Pax6-cre,GFP)2Pgr/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal retina vasculature morphology	J:201133
Ednrb^tm1Nrd/Ednrb^tm1Nrd Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J	abnormal enteric neural crest cell migration	J:140320
	aganglionic megacolon	J:140320
	distended abdomen	J:140320
	premature death	J:140320
	slow postnatal weight gain	J:140320
	white spotting	J:140320
Ednrb^tm1Nrd/Ednrb^tm1Nrd Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA/J	abnormal mature B cell number	J:233811
	abnormal Peyer's patch morphology	J:233811
	abnormal spleen morphology	J:233811
	abnormal splenic cell ratio	J:233811
	decreased B cell number	J:233811
	decreased germinal center B cell number	J:233811
	decreased IgA level	J:233811
	decreased marginal zone B cell number	J:233811
	decreased spleen red pulp amount	J:233811
	decreased spleen weight	J:233811
	decreased spleen white pulp amount	J:233811
	large intestinal inflammation	J:233811
	small Peyer's patches	J:233811
	small spleen	J:233811
Ednrb^tm1Nrd/Ednrb^tm1Nrd Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Tg(Tyr-cre/ERT2)13Bos/0 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J	abnormal coat/hair pigmentation	J:231435
	abnormal hair follicle melanocyte morphology	J:231435
	abnormal melanocyte proliferation	J:231435
	absent hair follicle melanin granules	J:231435
	decreased melanocyte number	J:231435
	reduced hair shaft melanin granule number	J:231435
Ednrb^tm1Ywa/Ednrb⁺ Tg(Mt1-RET)304Ina/0 involves: 129S7/SvEvBrd * BALB/c * C57BL/6	decreased tumor-free survival time	J:155735
	increased melanoma incidence	J:155735
	increased metastatic potential	J:155735

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24