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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Six3
sine oculis-related homeobox 3
MGI:102764
23 phenotypes from 5 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Six3tm1Gco/Six3tm1Gco
involves: 129S1/Sv 		abnormal craniofacial morphology J:81797
abnormal cranium morphology J:81797
abnormal forebrain development J:81797
abnormal neural tube morphology J:81797
abnormal rostral-caudal axis patterning J:81797
absent embryonic telencephalon J:81797
absent nasal placodes J:81797
absent optic pit J:81797
absent optic vesicle J:81797
anophthalmia J:81797
decreased forebrain size J:81797
increased midbrain size J:81797
perinatal lethality, complete penetrance J:81797
Six3tm2.1Gco/Six3tm2.1Gco
involves: 129S1/Sv 		abnormal forebrain development J:116102
decreased forebrain size J:116102
Six3tm2Gco/Six3tm2.1Gco
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S1/Sv * C57BL/6 * CBA 		abnormal lens development J:116102
abnormal lens fiber morphology J:116102
abnormal lens induction J:116102
abnormal lens morphology J:116102
abnormal lens vesicle development J:116102
abnormal optic vesicle formation J:116102
aphakia J:116102
cataract J:116102
small lens J:116102
Six3tm2Gco/Six3tm2.1Gco
Tg(Pax6-cre,GFP)1Pgr/0
involves: 129S1/Sv * FVB/N 		abnormal forebrain development J:116102
abnormal lens induction J:116102
Six3tm3Gco/Six3tm3Gco
Foxg1tm1(cre)Skm/Foxg1+
involves: 129S1/Sv * C57BL/6 		holoprosencephaly J:140315
Six3tm4(cre/ERT2)Gco/Six3+
involves: 129S1/Sv * C57BL/6 		holoprosencephaly J:140315
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory