Mfge8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mfge8
milk fat globule EGF and factor V/VIII domain containing
MGI:102768

25 phenotypes from 4 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mfge8^{Gt(KST227)Byg}/Mfge8^{Gt(KST227)Byg} B6.129P2-Mfge8^{Gt(KST227)Byg}	abnormal kidney physiology	J:98314
	abnormal physiological neovascularization	J:98314
	enlarged spleen	J:98314
	impaired macrophage phagocytosis	J:98314
	reduced male fertility	J:98314
Mfge8^{Gt(KST227)Byg}/Mfge8^{Gt(KST227)Byg} involves: 129P2/OlaHsd * C57BL/6	abnormal involution of the mammary gland	J:107106
	abnormal mammary gland duct morphology	J:107106
	enlarged spleen	J:107106
	impaired macrophage phagocytosis	J:107106
	mastitis	J:107106
	reduced male fertility	J:107106
Mfge8^tm1Mcu/Mfge8^tm1Mcu involves: 129X1/SvJ * C57BL/6NCr	enlarged spleen	J:123138
Mfge8^tm1Osa/Mfge8^tm1Osa B6.129-Mfge8^tm1Osa	abnormal involution of the mammary gland	J:103839
	abnormal mammary gland growth during lactation	J:103839
	abnormal milk composition	J:103839
	hypolactation	J:103839
	normal immune system phenotype	J:187181
Mfge8^tm1Osa/Mfge8^tm1Osa involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal lactation	J:103839
	abnormal spleen morphology	J:90633
	enlarged spleen	J:90633
	impaired macrophage phagocytosis	J:90633
	increased anti-double stranded DNA antibody level	J:225063
	increased spleen B cell follicle size	J:90633
	increased spleen weight	J:90633
	increased spleen white pulp amount	J:90633
	spleen hyperplasia	J:90633
Mfge8^tm1Shur/Mfge8^tm1Shur B6.129-Mfge8^tm1Shur	abnormal cell adhesion	J:145962
	abnormal epididymis morphology	J:145962
	epididymis epithelium degeneration	J:145962
	reduced male fertility	J:145962
	spermatic granuloma	J:145962
Mfge8^tm1Shur/Mfge8^tm1Shur involves: 129 * C57BL/6	decreased litter size	J:85225
	impaired binding of sperm to zona pellucida	J:85225
	reduced male fertility	J:85225

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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