Six2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Six2
sine oculis-related homeobox 2
MGI:102778

49 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cdc42^tm1Brak/Cdc42^tm1Brak Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ involves: 129 * C57BL/6J	abnormal kidney cortex morphology	J:195266
	abnormal kidney development	J:195266
	abnormal kidney papilla morphology	J:195266
	abnormal nephrogenic zone morphology	J:195266
	abnormal proximal convoluted tubule morphology	J:195266
	anuria	J:195266
	decreased renal glomerulus number	J:195266
	decreased renal tubule number	J:195266
	postnatal lethality, complete penetrance	J:195266
	renal hypoplasia	J:195266
Ctdnep1^tm3Ryn/Ctdnep1^tm3Ryn Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ involves: 129X1/SvJ * C57BL/6 * C57BL/6J	decreased kidney apoptosis	J:205755
Ctdnep1^tm3Ryn/Ctdnep1^tm3Ryn Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ involves: 129 * C57BL/6 * C57BL/6J	abnormal kidney morphology	J:205755
	abnormal nephron morphology	J:205755
	abnormal proximal convoluted tubule morphology	J:205755
	decreased kidney weight	J:205755
	premature death	J:205755
	renal glomerulus atrophy	J:205755
	small kidney	J:205755
Gt(ROSA)26Sor^{tm1(Notch1)Dam}/Gt(ROSA)26Sor⁺ Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ involves: 129S4/SvJaeSor * C57BL/6J	abnormal renal tubule morphology	J:185844
Gt(ROSA)26Sor^{tm1(Sall1)Ryn}/Gt(ROSA)26Sor⁺ Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ involves: 129P2/OlaHsd * C57BL/6 * CD-1	no abnormal phenotype detected	J:162052
Gt(ROSA)26Sor^{tm2(Notch2)Ryn}/Gt(ROSA)26Sor⁺ Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ involves: 129/Sv * 129P2/OlaHsd * C57BL/6J	abnormal kidney development	J:185844
	abnormal metanephric ureteric bud development	J:185844
	abnormal nephrogenic zone morphology	J:185844
	absent metanephric mesenchyme	J:185844
	dilated proximal convoluted tubule	J:185844
	dilated renal tubule	J:185844
	impaired branching involved in ureteric bud morphogenesis	J:185844
	neonatal lethality, complete penetrance	J:185844
	renal glomerulus cyst	J:185844
	small kidney	J:185844
Hnf4a^tm1Sad/Hnf4a^tm1Sad Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal kidney development	J:266356
	abnormal kidney morphology	J:266356
	abnormal proximal convoluted tubule morphology	J:266356
	increased urine glucose level	J:266356
	increased urine phosphate level	J:266356
	nephrocalcinosis	J:266356
	polydipsia	J:266356
	polyuria	J:266356
	small kidney	J:266356
Podxl^tm1Parl/Podxl^tm1Parl Podxl2^{tm1c(EUCOMM)Wtsi}/Podxl2^{tm1c(EUCOMM)Wtsi} Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	neonatal lethality, complete penetrance	J:240523
	normal renal/urinary system phenotype	J:240523
Six2^tm1Gco/Six2^tm1Gco Wnt9b^tm1.1Amc/Wnt9b^tm1.1Amc involves: 129/Sv * 129X1/SvJ * C57BL/6J	abnormal kidney development	J:148455
	delayed kidney development	J:148455
Six2^tm1Gco/Six2^tm1Gco Wnt9b^tm1.1Amc/Wnt9b^tm1.1Amc involves: 129X1/SvJ * C57BL/6J * NMRI	abnormal kidney development	J:148455
Srgap1^{tm1a(KOMP)Wtsi}/Srgap1^{tm1a(KOMP)Wtsi} Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ involves: 129 * C57BL/6J * C57BL/6N	abnormal glomerular filtration barrier function	J:333727
	absent podocyte slit diaphragm	J:333727
	albuminuria	J:333727
	decreased podocyte number	J:333727
	detached podocyte	J:333727
	dilated renal tubule	J:333727
	expanded mesangial matrix	J:333727
	glomerulosclerosis	J:333727
	increased mesangial cell number	J:333727
	podocyte foot process effacement	J:333727
	renal cast	J:333727
Wasl^tm2Sbs/Wasl^tm2Sbs Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ involves: 129 * C57BL/6J	decreased renal glomerulus number	J:195266
	decreased renal tubule number	J:195266
	renal hypoplasia	J:195266
Wwtr1^tm1Hmc/Wwtr1^tm1Hmc Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J	kidney cyst	J:195266
	kidney hemorrhage	J:195266
Wwtr1^tm1Hmc/Wwtr1^tm1Hmc Yap1^tm1Hmc/Yap1^tm1Hmc Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ involves: 129 * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl	abnormal kidney development	J:195266
	decreased renal glomerulus number	J:195266
	decreased renal tubule number	J:195266
	kidney cyst	J:195266
Yap1^tm1Hmc/Yap1^tm1Hmc Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl	abnormal kidney cortex morphology	J:195266
	abnormal kidney development	J:195266
	abnormal kidney medulla morphology	J:195266
	abnormal kidney papilla morphology	J:195266
	abnormal loop of Henle morphology	J:195266
	abnormal metanephros morphology	J:195266
	abnormal nephrogenic zone morphology	J:195266
	abnormal proximal convoluted tubule morphology	J:195266
	abnormal renal glomerulus morphology	J:195266
	abnormal renal tubule morphology	J:195266
	anuria	J:195266
	decreased renal glomerulus number	J:195266
	decreased renal tubule number	J:195266
	impaired branching involved in ureteric bud morphogenesis	J:195266
	podocyte foot process effacement	J:195266
	postnatal lethality, complete penetrance	J:195266
	renal hypoplasia	J:195266

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