About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Six1
sine oculis-related homeobox 1
MGI:102780
142 phenotypes from 9 alleles in 13 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Six1Cwe/Six1+
C3HeB/FeJ-Six1Cwe
abnormal inner ear vestibule morphology J:149467
abnormal otic vesicle development J:149467
head shaking J:149467
increased cochlear inner hair cell number J:149467
Six1Cwe/Six1Cwe
C3HeB/FeJ-Six1Cwe
abnormal cochlea morphology J:149467
abnormal common crus morphology J:149467
abnormal crista ampullaris morphology J:149467
abnormal inner ear canal morphology J:149467
absent incus J:149467
absent lateral semicircular canal J:149467
absent pinna reflex J:149467
circling J:149467
decreased body size J:149467
decreased body weight J:149467
decreased cochlear inner hair cell number J:149467
head shaking J:149467
impaired righting response J:149467
inner ear hypoplasia J:149467
limb grasping J:149467
renal hypoplasia J:149467
small utricle J:149467
small vestibular saccule J:149467
Six1em1(IMPC)Mbp/Six1+
C57BL/6N-Six1em1(IMPC)Mbp/MbpMmucd
abnormal blood vessel morphology J:211773
abnormal kidney morphology J:211773
abnormal placenta morphology J:211773
abnormal placenta vasculature J:211773
abnormal retina morphology J:211773
abnormal skin morphology J:211773
abnormal spleen morphology J:211773
abnormal uterus morphology J:211773
decreased circulating calcium level J:211773
decreased heart rate J:211773
decreased leukocyte cell number J:211773
decreased prepulse inhibition J:211773
edema J:211773
enlarged cecum J:211773
enlarged heart J:211773
enlarged kidney J:211773
enlarged spleen J:211773
prolonged RR interval J:211773
small kidney J:211773
small spleen J:211773
Six1em1(IMPC)Mbp/Six1em1(IMPC)Mbp
C57BL/6N-Six1em1(IMPC)Mbp/MbpMmucd
abnormal blood vessel morphology J:211773
abnormal craniofacial morphology J:211773
abnormal placenta morphology J:211773
edema J:211773
embryonic growth retardation J:211773
preweaning lethality, complete penetrance J:211773
Six1tm1Kwk/Six1tm1Kwk
involves: 129P2/OlaHsd * C57BL/6
abnormal endolymphatic duct morphology J:104488
abnormal external nares morphology J:104488
abnormal incus morphology J:104488
abnormal inner ear morphology J:104488
abnormal kidney morphology J:104488
abnormal malleus morphology J:104488
abnormal middle ear morphology J:104488
abnormal nasal cavity morphology J:104488
abnormal nose morphology J:104488
abnormal otic vesicle development J:104488
abnormal semicircular canal morphology J:104488
abnormal submandibular gland development J:155993
abnormal submandibular gland physiology J:155993
absent cochlea J:104488
absent inner ear vestibule J:104488
absent kidney J:104488
absent olfactory epithelium J:104488
absent stapes J:104488
absent vestibulocochlear ganglion J:104488
absent vomeronasal organ J:104488
apnea J:104488
athymia J:104488
bradykinesia J:104488
decreased skeletal muscle mass J:104488
decreased submandibular gland size J:155993
dilated endolymphatic duct J:104488
epistaxis J:104488
eyelids open at birth J:104488
micrognathia J:104488
perinatal lethality, complete penetrance J:104488
short ureter J:104488
small kidney J:104488
Six1tm1Mair/Six1+
either: (involves: 129) or (involves: 129 * C57BL/6)
abnormal cochlea morphology J:84974
abnormal facial nerve morphology J:84974
abnormal middle ear morphology J:84974
abnormal stapes morphology J:84974
abnormal tympanic membrane morphology J:84974
absent stapedial artery J:84974
conductive hearing loss J:84974
increased or absent threshold for auditory brainstem response J:84974
unilateral deafness J:84974
Six1tm1Mair/Six1+
involves: 129 * C57BL/6J
abnormal vestibular saccule morphology J:119574
decreased cochlea coiling J:119574
short endolymphatic duct J:119574
Six1tm1Mair/Six1tm1Mair
either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)
abnormal genioglossus muscle morphology J:82459
abnormal hypaxial muscle morphology J:82459
abnormal intercostal muscle morphology J:82459
abnormal muscle fiber morphology J:82459
abnormal myogenesis J:82459
abnormal rib morphology J:82459
abnormal sternocostal joint morphology J:82459
abnormal sternum ossification J:82459
abnormal xiphoid process morphology J:82459
decreased skeletal muscle mass J:82459
decreased tongue size J:82459
muscle hypoplasia J:82459
perinatal lethality, complete penetrance J:82459
rib bifurcation J:82459
rib fusion J:82459
thin diaphragm muscle J:82459
Six1tm1Mair/Six1tm1Mair
involves: 129 * C57BL/6 * CD-1 * SJL
abnormal cardiovascular development J:172023
Six1tm1Mair/Six1tm1Mair
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal cardiac outflow tract development J:172023
abnormal common carotid artery morphology J:172023
abnormal face development J:172023
abnormal midface morphology J:172023
abnormal skeletal muscle morphology J:172023
micrognathia J:172023
Six1tm1Mair/Six1tm1Mair
involves: 129S2/SvPas
abnormal cranial neural crest cell morphology J:84417
abnormal craniofacial bone morphology J:84417
abnormal epaxial muscle morphology J:84417
abnormal frontal bone morphology J:84417
abnormal hyoid bone greater horn morphology J:84417
abnormal hypaxial muscle morphology J:84417
abnormal inner ear morphology J:84417
abnormal lacrimal gland development J:84417
abnormal Meckel's cartilage morphology J:84417
abnormal nasal bone morphology J:84417
abnormal nasal cavity morphology J:84417
abnormal nose morphology J:84417
abnormal olfactory epithelium morphology J:84417
abnormal olfactory system morphology J:84417
abnormal styloid process morphology J:84417
absent diaphragm J:84417
absent kidney J:84417
absent metanephros J:84417
absent parotid gland J:84417
absent scala media J:84417
absent semicircular canals J:84417
absent turbinates J:84417
athymia J:84417
cervical vertebral fusion J:84417
decreased otic epithelial cell proliferation J:84417
decreased submandibular gland size J:84417
decreased tongue size J:84417
perinatal lethality, complete penetrance J:84417
short mandible J:84417
short maxilla J:84417
short temporal bone squamous part J:84417
short zygomatic bone J:84417
small otic capsule J:84417
Six1tm1Px/Six1tm1Px
Tg(Atoh1-cre/Esr1*)14Fsh/0
involves: FVB/N
abnormal cochlear hair cell morphology J:181471
Six1tm1Rsd/Six1tm1Rsd
involves: 129S1/Sv * 129X1/SvJ
abnormal hypaxial muscle morphology J:86619
abnormal kidney development J:86619
abnormal muscle precursor cell migration J:86619
abnormal nose morphology J:86619
abnormal thoracic cage morphology J:86619
absent inner ear J:86619
absent kidney J:86619
absent semicircular canals J:86619
decreased cell proliferation J:86619
increased apoptosis J:86619
rib fusion J:86619
small adenohypophysis J:86619
small kidney J:86619
Six1tm2.1Mair/Six1tm2.1Mair
Pax7tm1(cre/ERT2)Gaka/Pax7+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6Cr * C57BL/6NTac
abnormal muscle physiology J:190460
abnormal muscle regeneration J:190460
normal muscle phenotype J:190460
skeletal muscle fibrosis J:190460
Six1tm2.2Mair/Six1tm2.2Mair
involves: C57BL/6NTac
abnormal myogenesis J:190460
Six1tm2Kwk/Six1tm2Kwk
involves: 129P2/OlaHsd * C57BL/6
abnormal nervous system physiology J:114468
abnormal trigeminal ganglion morphology J:114468
increased neuron apoptosis J:114468

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory