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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Six1
sine oculis-related homeobox 1
MGI:102780
142 phenotypes from 9 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Six1Cwe/Six1+
C3HeB/FeJ-Six1Cwe 		abnormal inner ear vestibule morphology J:149467
abnormal otic vesicle development J:149467
head shaking J:149467
increased cochlear inner hair cell number J:149467
Six1Cwe/Six1Cwe
C3HeB/FeJ-Six1Cwe 		abnormal cochlea morphology J:149467
abnormal common crus morphology J:149467
abnormal crista ampullaris morphology J:149467
abnormal inner ear canal morphology J:149467
absent incus J:149467
absent lateral semicircular canal J:149467
absent pinna reflex J:149467
circling J:149467
decreased body size J:149467
decreased body weight J:149467
decreased cochlear inner hair cell number J:149467
head shaking J:149467
impaired righting response J:149467
inner ear hypoplasia J:149467
limb grasping J:149467
renal hypoplasia J:149467
small utricle J:149467
small vestibular saccule J:149467
Six1em1(IMPC)Mbp/Six1+
C57BL/6N-Six1em1(IMPC)Mbp/MbpMmucd 		abnormal blood vessel morphology J:211773
abnormal kidney morphology J:211773
abnormal placenta morphology J:211773
abnormal placenta vasculature J:211773
abnormal retina morphology J:211773
abnormal skin morphology J:211773
abnormal spleen morphology J:211773
abnormal uterus morphology J:211773
decreased circulating calcium level J:211773
decreased heart rate J:211773
decreased leukocyte cell number J:211773
decreased prepulse inhibition J:211773
edema J:211773
enlarged cecum J:211773
enlarged heart J:211773
enlarged kidney J:211773
enlarged spleen J:211773
prolonged RR interval J:211773
small kidney J:211773
small spleen J:211773
Six1em1(IMPC)Mbp/Six1em1(IMPC)Mbp
C57BL/6N-Six1em1(IMPC)Mbp/MbpMmucd 		abnormal blood vessel morphology J:211773
abnormal craniofacial morphology J:211773
abnormal placenta morphology J:211773
edema J:211773
embryonic growth retardation J:211773
preweaning lethality, complete penetrance J:211773
Six1tm1Kwk/Six1tm1Kwk
involves: 129P2/OlaHsd * C57BL/6 		abnormal endolymphatic duct morphology J:104488
abnormal external nares morphology J:104488
abnormal incus morphology J:104488
abnormal inner ear morphology J:104488
abnormal kidney morphology J:104488
abnormal malleus morphology J:104488
abnormal middle ear morphology J:104488
abnormal nasal cavity morphology J:104488
abnormal nose morphology J:104488
abnormal otic vesicle development J:104488
abnormal semicircular canal morphology J:104488
abnormal submandibular gland development J:155993
abnormal submandibular gland physiology J:155993
absent cochlea J:104488
absent inner ear vestibule J:104488
absent kidney J:104488
absent olfactory epithelium J:104488
absent stapes J:104488
absent vestibulocochlear ganglion J:104488
absent vomeronasal organ J:104488
apnea J:104488
athymia J:104488
bradykinesia J:104488
decreased skeletal muscle mass J:104488
decreased submandibular gland size J:155993
dilated endolymphatic duct J:104488
epistaxis J:104488
eyelids open at birth J:104488
micrognathia J:104488
perinatal lethality, complete penetrance J:104488
short ureter J:104488
small kidney J:104488
Six1tm1Mair/Six1+
either: (involves: 129) or (involves: 129 * C57BL/6) 		abnormal cochlea morphology J:84974
abnormal facial nerve morphology J:84974
abnormal middle ear morphology J:84974
abnormal stapes morphology J:84974
abnormal tympanic membrane morphology J:84974
absent stapedial artery J:84974
conductive hearing loss J:84974
increased or absent threshold for auditory brainstem response J:84974
unilateral deafness J:84974
Six1tm1Mair/Six1+
involves: 129 * C57BL/6J 		abnormal vestibular saccule morphology J:119574
decreased cochlea coiling J:119574
short endolymphatic duct J:119574
Six1tm1Mair/Six1tm1Mair
either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) 		abnormal genioglossus muscle morphology J:82459
abnormal hypaxial muscle morphology J:82459
abnormal intercostal muscle morphology J:82459
abnormal muscle fiber morphology J:82459
abnormal myogenesis J:82459
abnormal rib morphology J:82459
abnormal sternocostal joint morphology J:82459
abnormal sternum ossification J:82459
abnormal xiphoid process morphology J:82459
decreased skeletal muscle mass J:82459
decreased tongue size J:82459
muscle hypoplasia J:82459
perinatal lethality, complete penetrance J:82459
rib bifurcation J:82459
rib fusion J:82459
thin diaphragm muscle J:82459
Six1tm1Mair/Six1tm1Mair
involves: 129 * C57BL/6 * CD-1 * SJL 		abnormal cardiovascular development J:172023
Six1tm1Mair/Six1tm1Mair
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cardiac outflow tract development J:172023
abnormal common carotid artery morphology J:172023
abnormal face development J:172023
abnormal midface morphology J:172023
abnormal skeletal muscle morphology J:172023
micrognathia J:172023
Six1tm1Mair/Six1tm1Mair
involves: 129S2/SvPas 		abnormal cranial neural crest cell morphology J:84417
abnormal craniofacial bone morphology J:84417
abnormal epaxial muscle morphology J:84417
abnormal frontal bone morphology J:84417
abnormal hyoid bone greater horn morphology J:84417
abnormal hypaxial muscle morphology J:84417
abnormal inner ear morphology J:84417
abnormal lacrimal gland development J:84417
abnormal Meckel's cartilage morphology J:84417
abnormal nasal bone morphology J:84417
abnormal nasal cavity morphology J:84417
abnormal nose morphology J:84417
abnormal olfactory epithelium morphology J:84417
abnormal olfactory system morphology J:84417
abnormal styloid process morphology J:84417
absent diaphragm J:84417
absent kidney J:84417
absent metanephros J:84417
absent parotid gland J:84417
absent scala media J:84417
absent semicircular canals J:84417
absent turbinates J:84417
athymia J:84417
cervical vertebral fusion J:84417
decreased otic epithelial cell proliferation J:84417
decreased submandibular gland size J:84417
decreased tongue size J:84417
perinatal lethality, complete penetrance J:84417
short mandible J:84417
short maxilla J:84417
short temporal bone squamous part J:84417
short zygomatic bone J:84417
small otic capsule J:84417
Six1tm1Px/Six1tm1Px
Tg(Atoh1-cre/Esr1*)14Fsh/0
involves: FVB/N 		abnormal cochlear hair cell morphology J:181471
Six1tm1Rsd/Six1tm1Rsd
involves: 129S1/Sv * 129X1/SvJ 		abnormal hypaxial muscle morphology J:86619
abnormal kidney development J:86619
abnormal muscle precursor cell migration J:86619
abnormal nose morphology J:86619
abnormal thoracic cage morphology J:86619
absent inner ear J:86619
absent kidney J:86619
absent semicircular canals J:86619
decreased cell proliferation J:86619
increased apoptosis J:86619
rib fusion J:86619
small adenohypophysis J:86619
small kidney J:86619
Six1tm2.1Mair/Six1tm2.1Mair
Pax7tm1(cre/ERT2)Gaka/Pax7+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6Cr * C57BL/6NTac 		abnormal muscle physiology J:190460
abnormal muscle regeneration J:190460
normal muscle phenotype J:190460
skeletal muscle fibrosis J:190460
Six1tm2.2Mair/Six1tm2.2Mair
involves: C57BL/6NTac 		abnormal myogenesis J:190460
Six1tm2Kwk/Six1tm2Kwk
involves: 129P2/OlaHsd * C57BL/6 		abnormal nervous system physiology J:114468
abnormal trigeminal ganglion morphology J:114468
increased neuron apoptosis J:114468
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory