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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Six1
sine oculis-related homeobox 1
MGI:102780
75 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Eya1tm1Rilm/Eya1+
Pax2tm1Pgr/Pax2+
Six1tm1Mair/Six1+
involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal cochlea morphology J:119574
abnormal semicircular canal ampulla morphology J:119574
abnormal semicircular canal morphology J:119574
abnormal vestibular saccule morphology J:119574
decreased cochlea coiling J:119574
decreased lateral semicircular canal size J:119574
decreased posterior semicircular canal size J:119574
decreased superior semicircular canal size J:119574
short endolymphatic duct J:119574
small vestibular saccule J:119574
Eya1tm1Rilm/Eya1+
Six1tm1Mair/Six1+
involves: 129/Sv * 129S1/Sv * 129X1/SvJ 		abnormal ureteric bud morphology J:83432
absent kidney J:83432
impaired branching involved in ureteric bud morphogenesis J:83432
renal hypoplasia J:83432
single kidney J:83432
Eya1tm1Rilm/Eya1+
Six1tm1Mair/Six1+
involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal ureteric bud morphology J:83432
impaired branching involved in ureteric bud morphogenesis J:83432
renal hypoplasia J:83432
single kidney J:83432
Eya1tm1Rilm/Eya1+
Six1tm1Mair/Six1+
involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal cochlea morphology J:119574
abnormal inner ear morphology J:119574
abnormal semicircular canal ampulla morphology J:119574
abnormal semicircular canal morphology J:119574
abnormal vestibular saccule morphology J:119574
decreased cochlea coiling J:119574
decreased lateral semicircular canal size J:119574
decreased posterior semicircular canal size J:119574
decreased superior semicircular canal size J:119574
short endolymphatic duct J:119574
Eya1tm1Rilm/Eya1+
Six1tm1Mair/Six1tm1Mair
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cardiac outflow tract development J:172023
abnormal common carotid artery morphology J:172023
double outlet right ventricle J:172023
retroesophageal right subclavian artery J:172023
right aortic arch J:172023
Eya1tm1Rilm/Eya1+
Six1tm1Rsd/Six1+
involves: 129S1/Sv * 129X1/SvJ 		renal hypoplasia J:86619
single kidney J:86619
Eya1tm1Rilm/Eya1tm1Rilm
Six1tm1Mair/Six1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cardiac outflow tract development J:172023
double outlet right ventricle J:172023
interrupted aortic arch J:172023
retroesophageal right subclavian artery J:172023
vascular ring J:172023
Eya1tm1Rilm/Eya1tm1Rilm
Six1tm1Mair/Six1tm1Mair
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cardiac outflow tract development J:172023
abnormal craniofacial development J:172023
abnormal extraocular muscle morphology J:172023
abnormal pulmonary artery morphology J:172023
abnormal skeletal muscle morphology J:172023
decreased cell proliferation J:172023
double outlet right ventricle J:172023
facial muscle hypoplasia J:172023
increased apoptosis J:172023
interrupted aortic arch, type b J:172023
persistent truncus arteriosus J:172023
retroesophageal right subclavian artery J:172023
right aortic arch J:172023
tongue muscle hypoplasia J:172023
vascular ring J:172023
Eya1tm1Rilm/Eya1tm1Rilm
Six1tm1Rsd/Six1tm1Rsd
involves: 129S1/Sv * 129X1/SvJ 		abnormal epaxial muscle morphology J:86619
absent hypaxial muscle J:86619
absent kidney J:86619
pituitary gland hypoplasia J:86619
small pituitary gland J:86619
Fgf8tm1.3Mrt/Fgf8+
Six1tm1(cre)Xli/Six1+
involves: 129 * 129P2/OlaHsd * C57BL/6 		abnormal cardiac outflow tract development J:172023
cervical aortic arch J:172023
interrupted aortic arch J:172023
Jag1Mhdahtu/Jag1+
Six1Cwe/Six1+
C3HeB/FeJ-C3HeB/FeJ-Jag1Htu Six1Cwe 		abnormal crista ampullaris morphology J:149467
abnormal inner ear canal morphology J:149467
abnormal posterior semicircular canal morphology J:149467
abnormal superior semicircular canal morphology J:149467
circling J:149467
head bobbing J:149467
Six1tm1Kwk/Six1tm1Kwk
Six4tm1Kwk/Six4tm1Kwk
involves: 129P2/OlaHsd 		abnormal dorsal root ganglion morphology J:103002
neonatal lethality, complete penetrance J:103002
Six1tm1Mair/Six1tm1Mair
Six4tm1Mair/Six4tm1Mair
either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair 		abnormal forelimb morphology J:98519
abnormal genioglossus muscle morphology J:98519
abnormal hindlimb morphology J:98519
abnormal inner ear morphology J:98519
abnormal intrinsic tongue muscle morphology J:98519
abnormal muscle development J:98519
abnormal muscle precursor cell migration J:98519
abnormal skeletal muscle morphology J:98519
abnormal sternocostal joint morphology J:98519
absent eye muscles J:98519
absent hypaxial muscle J:98519
absent maxillary shelf J:98519
absent Meckel's cartilage J:98519
absent nasal bone J:98519
absent premaxilla J:98519
absent tongue muscles J:98519
absent tympanic ring J:98519
absent zygomatic bone J:98519
anotia J:98519
decreased embryo size J:98519
distended abdomen J:98519
exophthalmos J:98519
eyelids open at birth J:98519
muscle hypoplasia J:98519
perinatal lethality, complete penetrance J:98519
short mandible J:98519
short maxilla J:98519
short ribs J:98519
small orbits J:98519
small temporal bone J:98519
trunk curl J:98519
Six1tm1Mair/Six1tm1Mair
Tbx1tm1Bem/Tbx1tm1Bem
involves: 129 * C57BL/6 * CD-1 * SJL 		abnormal cardiovascular development J:172023
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory