Acvr2a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Acvr2a
activin receptor IIA
MGI:102806

38 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Acvr2a^{tm1.1(KOMP)Vlcg}/Acvr2a⁺ C57BL/6N-Acvr2a^{tm1.1(KOMP)Vlcg}/Ucd	abnormal behavior	J:211773
	decreased eosinophil cell number	J:211773
	decreased neutrophil cell number	J:211773
	increased thigmotaxis	J:211773
Acvr2a^{tm1.1(KOMP)Vlcg}/Acvr2a^{tm1.1(KOMP)Vlcg} C57BL/6N-Acvr2a^{tm1.1(KOMP)Vlcg}/Ucd	abnormal craniofacial morphology	J:211773
	abnormal embryo size	J:211773
	anophthalmia	J:211773
	microphthalmia	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Acvr2a^tm1Hsch/Acvr2a^tm1Hsch involves: 129S1/Sv * C57BL/6J	abnormal gastrulation	J:57262
	abnormal testis development	J:57262
	cyclopia	J:57262
	embryonic lethality during organogenesis, incomplete penetrance	J:57262
	mandible hypoplasia	J:57262
	reduced female fertility	J:57262
Acvr2a^tm1Zuk/Acvr2a^tm1Zuk either: 129 or (involves: 129S7/SvEvBrd * C57BL/6)	abnormal craniofacial bone morphology	J:23924
	abnormal estrous cycle	J:23924
	abnormal eyelid morphology	J:23924
	abnormal ovary morphology	J:23924
	abnormal seminiferous tubule morphology	J:23924
	absent corpus luteum	J:23924
	absent incisors	J:23924
	azoospermia	J:23924
	cleft palate	J:23924
	delayed male fertility	J:23924
	normal endocrine/exocrine gland phenotype	J:23924
	female infertility	J:23924
	increased atretic ovarian follicle number	J:23924
	mandible hypoplasia	J:23924
	neonatal lethality, complete penetrance	J:23924
	normal reproductive system phenotype	J:23924
	small testis	J:23924
	suppressed circulating follicle stimulating hormone level	J:23924
	thin uterus	J:23924
Acvr2a^tm1Zuk/Acvr2a^tm1Zuk involves: 129S7/SvEvBrd	abnormal Sertoli cell morphology	J:71932
	abnormal spermatid morphology	J:71932
	abnormal spermatogonia morphology	J:71932
	decreased male germ cell number	J:71932
	decreased testis weight	J:71932

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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