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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Acvr2a
activin receptor IIA
MGI:102806
62 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Acvr2atm1Hsch/Acvr2a+
Acvr2btm1Enl/Acvr2btm1Enl
involves: 129S1/Sv * 129S4/SvJae * C57BL/6J 		perinatal lethality, complete penetrance J:57262
Acvr2atm1Hsch/Acvr2a+
Bmpr2tm1.1Enl/Bmpr2tm1.1Enl
Tg(KRT14-cre)1Ipc/0
involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * SJL 		abnormal auchene hair morphology J:189569
abnormal awl hair morphology J:189569
abnormal coat/ hair morphology J:189569
abnormal hair cycle J:189569
abnormal hair cycle catagen phase J:189569
abnormal hair follicle outer root sheath morphology J:189569
abnormal hair follicle regression J:189569
abnormal hair growth J:189569
abnormal hair medulla J:189569
abnormal hair medullary septa cells J:189569
abnormal hair shaft melanin granule distribution J:189569
abnormal hair shaft morphology J:189569
abnormal zigzag hair morphology J:189569
absent hair club J:189569
alopecia J:189569
early exit from anagen phase J:189569
early exit from telogen phase J:189569
increased curvature of awl hairs J:189569
increased curvature of guard hairs J:189569
increased hair follicle cell proliferation J:189569
long nails J:189569
premature hair regrowth J:189569
striated fur J:189569
thick epidermis J:189569
thin hair shaft J:189569
Acvr2atm1Hsch/Acvr2a+
Acvr2btm1Spo/Acvr2btm1Spo
involves: 129S1/Sv * 129S4/SvJae 		abnormal left-right axis patterning J:114533
lumbar vertebral transformation J:114533
right pulmonary isomerism J:114533
transposition of great arteries J:114533
Acvr2atm1Hsch/Acvr2a+
Acvr2btm1.1Spo/Acvr2btm1.1Spo
involves: 129S1/Sv * 129S4/SvJae * FVB/N 		abnormal left-right axis patterning J:114533
lumbar vertebral transformation J:114533
right pulmonary isomerism J:114533
transposition of great arteries J:114533
Acvr2atm1Hsch/Acvr2atm1Hsch
Acvr2btm1.1Spo/Acvr2btm1.1Spo
involves: 129S1/Sv * 129S4/SvJae * FVB/N 		abnormal embryonic tissue morphology J:114533
embryonic growth arrest J:114533
embryonic lethality between somite formation and embryo turning J:114533
embryonic-extraembryonic boundary constriction J:114533
Acvr2atm1Hsch/Acvr2atm1Hsch
Acvr2btm1Enl/Acvr2b+
involves: 129S1/Sv * 129S4/SvJae * C57BL/6J 		abnormal gastrulation J:57262
abnormal mesoderm development J:57262
abnormal primitive streak elongation J:57262
abnormal rostral-caudal axis patterning J:57262
absent allantois J:57262
absent amnion J:57262
absent head fold J:57262
absent heart tube J:57262
embryonic growth arrest J:57262
embryonic lethality between implantation and somite formation, complete penetrance J:57262
embryonic-extraembryonic boundary constriction J:57262
Acvr2atm1Hsch/Acvr2atm1Hsch
Acvr2btm1Enl/Acvr2btm1Enl
involves: 129S1/Sv * 129S4/SvJae * C57BL/6J 		absent mesoderm J:57262
embryonic growth arrest J:57262
embryonic lethality between implantation and somite formation, complete penetrance J:57262
embryonic-extraembryonic boundary constriction J:57262
failure to gastrulate J:57262
increased embryonic epiblast cell apoptosis J:57262
Acvr2atm1Hsch/Acvr2atm1Hsch
Bmpr2tm1.1Enl/Bmpr2tm1.1Enl
Tg(KRT14-cre)1Ipc/0
involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * SJL 		abnormal hair follicle development J:189569
abnormal hair growth J:189569
abnormal vibrissa follicle morphology J:189569
absent hair follicle bulb J:189569
absent vibrissae J:189569
eyelids open at birth J:189569
perinatal lethality, complete penetrance J:189569
underdeveloped hair follicles J:189569
Acvr2atm1Hsch/Acvr2atm1Hsch
Bmpr2tm1.1Enl/Bmpr2tm1.1Enl
Tg(Tyr-cre)1Lru/Y
involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * DBA/2 		abnormal coat/hair pigmentation J:189569
abnormal hair follicle melanin granule morphology J:189569
diluted coat color J:189569
reduced hair shaft melanin granule number J:189569
small melanosome J:189569
Acvr2atm1Hsch/Acvr2atm1Hsch
Bmpr2tm1.1Enl/Bmpr2tm1.1Enl
Tg(Tyr-cre)1Lru/0
involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * DBA/2 		mosaic coat color J:189569
Acvr2atm1Hsch/Acvr2atm1Hsch
Nodaltm1Rob/Nodal+
involves: 129S/SvEv * 129S1/Sv * C57BL/6J 		abnormal gastrulation J:57262
abnormal head morphology J:57262
cyclopia J:57262
decreased forebrain size J:57262
embryonic lethality, complete penetrance J:57262
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory