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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mybpc3
myosin binding protein C, cardiac
MGI:102844
43 phenotypes from 9 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mybpc3tm1.1Jse/Mybpc3tm1.1Jse
Not Specified 		abnormal heart left ventricle morphology J:58295
abnormal M line morphology J:58295
abnormal myocardial fiber morphology J:58295
abnormal ventricle papillary muscle morphology J:58295
cardiac fibrosis J:58295
cardiac interstitial fibrosis J:58295
decreased heart ventricle muscle contractility J:58295
dilated cardiomyopathy J:58295
dilated heart left atrium J:58295
dilated heart left ventricle J:58295
disorganized myocardium J:58295
dystrophic cardiac calcinosis J:58295
enlarged heart J:58295
heart left ventricle hypertrophy J:58295
increased heart weight J:58295
thick ventricular wall J:58295
Mybpc3tm1a(EUCOMM)Hmgu/Mybpc3tm1a(EUCOMM)Hmgu
Not Specified 		abnormal response to new environment J:165965
decreased circulating amylase level J:165965
increased circulating chloride level J:165965
increased heart weight J:165965
Mybpc3tm1Jse/Mybpc3tm1Jse
involves: 129S/SvEv 		abnormal cardiac muscle contractility J:98868
abnormal cardiac muscle relaxation J:98868
decreased cardiac stroke volume J:98868
dilated cardiomyopathy J:98868
dilated heart left ventricle J:98868
increased cardiac muscle contractility J:98868
increased heart weight J:98868
Mybpc3tm1Jse/Mybpc3tm1Jse
Not Specified 		abnormal heart left ventricle morphology J:58295
abnormal M line morphology J:58295
abnormal myocardial fiber morphology J:58295
abnormal ventricle papillary muscle morphology J:58295
cardiac fibrosis J:58295
cardiac interstitial fibrosis J:58295
decreased heart left ventricle muscle contractility J:58295
dilated cardiomyopathy J:58295
dilated heart left atrium J:58295
dilated heart left ventricle J:58295
dystrophic cardiac calcinosis J:58295
enlarged heart J:58295
heart left ventricle hypertrophy J:58295
increased heart weight J:58295
myocardial fiber disarray J:58295
thick ventricular wall J:58295
Mybpc3tm1Lcrr/Mybpc3+
involves: 129S4/SvJae * Black Swiss 		heart left ventricle hypertrophy J:101903
Mybpc3tm1Lcrr/Mybpc3tm1Lcrr
involves: 129S4/SvJae * Black Swiss 		abnormal cardiac muscle contractility J:105732
cardiac hypertrophy J:105732
cardiac interstitial fibrosis J:101903
decreased cardiac muscle contractility J:101903
heart left ventricle hypertrophy J:101903
impaired muscle relaxation J:101903
Mybpc3tm1Rmos/Mybpc3tm1Rmos
either: (involves: 129) or (involves: 129 * C57BL/6) 		abnormal heart morphology J:95725
abnormal myocardial fiber physiology J:109391
cardiac hypertrophy J:95725
cardiac interstitial fibrosis J:95725
cardiomyopathy J:95725
decreased cardiac muscle contractility J:95725
decreased heart left ventricle muscle contractility J:95725
dilated heart left ventricle J:95725
myocardial fiber disarray J:95725
Mybpc3tm1Rmos/Mybpc3tm1Rmos
involves: 129 		decreased heart ventricle muscle contractility J:202199
dilated heart left ventricle J:202199
increased response of heart to induced stress J:202199
Mybpc3tm2.1Lcrr/Mybpc3+
involves: 129S2/SvPasCrl * Black Swiss 		abnormal cardiac muscle relaxation J:185726
abnormal myocardial fiber physiology J:185726
Mybpc3tm2.1Lcrr/Mybpc3+
involves: 129S2/SvPasCrl * Black Swiss * C57BL/6 * CD-1 * DBA/2 		increased myocardial fiber size J:164934
Mybpc3tm2.1Lcrr/Mybpc3tm2.1Lcrr
involves: 129S2/SvPasCrl * Black Swiss 		abnormal cardiac muscle relaxation J:185726
abnormal heart echocardiography feature J:185726
abnormal myocardial fiber physiology J:185726
decreased cardiac muscle contractility J:185726
heart left ventricle hypertrophy J:185726
Mybpc3tm2.1Lcrr/Mybpc3tm2.1Lcrr
involves: 129S2/SvPasCrl * Black Swiss * C57BL/6 * CD-1 * DBA/2 		abnormal heart left ventricle morphology J:164934
cardiac interstitial fibrosis J:164934
decreased cardiac muscle contractility J:164934
heart left ventricle hypertrophy J:164934
increased heart weight J:164934
increased myocardial fiber size J:164934
Mybpc3tm2.1Rmos/Mybpc3tm2.1Rmos
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129 * C57BL/6 * FVB/N 		abnormal heart left ventricle morphology J:202199
cardiac fibrosis J:202199
cardiac interstitial fibrosis J:202199
normal cardiovascular system phenotype J:202199
decreased heart ventricle muscle contractility J:202199
increased myocardial fiber size J:202199
increased response of heart to induced stress J:202199
myocardial fiber disarray J:202199
Tg(Myh6-Mybpc3*)24Rbns/0
Not Specified 		abnormal heart morphology J:59702
abnormal myocardial fiber mitochondrial morphology J:59702
abnormal myocardial fiber physiology J:59702
abnormal sarcomere morphology J:59702
abnormal Z line morphology J:59702
cardiac hypertrophy J:59702
decreased heart rate J:59702
impaired exercise endurance J:59702
increased heart weight J:59702
Tg(Myh6-Mybpc3*)32Rbns/0
Not Specified 		abnormal heart morphology J:127656
abnormal myocardial fiber morphology J:50237
abnormal myocardial fiber physiology J:50237
abnormal sarcomere morphology J:50237
cardiac hypertrophy J:127656
decreased heart rate J:127656
impaired exercise endurance J:127656
increased heart weight J:127656
increased response of heart to induced stress J:127656
increased susceptibility to induced morbidity/mortality J:127656
myocardial fiber degeneration J:50237
sinus bradycardia J:127656
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory