Bdkrb2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Bdkrb2
bradykinin receptor, beta 2
MGI:102845

24 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ace^tm4Keb/Ace^tm4Keb Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ	abnormal kidney vasculature morphology	J:83894
	abnormal response/metabolism to endogenous compounds	J:83894
	decreased hematocrit	J:83894
	decreased kidney weight	J:83894
	decreased systemic arterial systolic blood pressure	J:83894
	decreased urine osmolality	J:83894
	kidney cyst	J:83894
	vascular inflammation	J:83894
Bdkrb1^tm2Bdr/Bdkrb1^tm2Bdr Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh involves: 129S7/SvEvBrd * C57BL/6	normal cardiovascular system phenotype	J:135789
	decreased heart rate	J:135789
	decreased physiological sensitivity to xenobiotic	J:135789
	decreased susceptibility to endotoxin shock	J:135789
Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh Ins2^Akita/Ins2⁺ B6.Cg-Ins2^Akita Bdkrb2^tm1Jfh	abnormal intestinal epithelium morphology	J:108948
	abnormal Leydig cell morphology	J:108948
	abnormal mitochondrial chromosome morphology	J:108948
	abnormal seminiferous tubule morphology	J:108948
	abnormal spermatic cord morphology	J:108948
	abnormal spermatogonia morphology	J:108948
	alopecia	J:108948
	decreased bone mineral density	J:108948
	decreased subcutaneous adipose tissue amount	J:108948
	kyphosis	J:108948
	premature death	J:108948
Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh Serping1^Gt1Aed/Serping1^Gt1Aed involves: 129S5/SvEvBrd * C57BL/6	no abnormal phenotype detected	J:76090

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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