Pdx1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pdx1
pancreatic and duodenal homeobox 1
MGI:102851

70 phenotypes from 10 alleles in 14 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pdx1^tm1.1Stof/Pdx1⁺ involves: 129/Sv * C57BL/6	abnormal pancreatic endocrine progenitor cell physiology	J:152582
	decreased circulating insulin level	J:152582
	decreased pancreatic beta cell mass	J:152582
	impaired glucose tolerance	J:152582
	pancreas hypoplasia	J:152582
Pdx1^tm1.1Stof/Pdx1^tm1.1Stof involves: 129/Sv * C57BL/6	abnormal pancreas development	J:152582
	abnormal pancreatic delta cell morphology	J:152582
	abnormal pancreatic epsilon cell morphology	J:152582
	abnormal PP cell morphology	J:152582
	decreased circulating insulin level	J:152582
	decreased pancreatic alpha cell mass	J:152582
	decreased pancreatic beta cell mass	J:152582
	normal endocrine/exocrine gland phenotype	J:152582
	hyperglycemia	J:152582
	impaired glucose tolerance	J:152582
	pancreatic islet hypoplasia	J:152582
Pdx1^{tm1b(EUCOMM)Wtsi}/Pdx1⁺ C57BL/6N-Pdx1^{tm1b(EUCOMM)Wtsi}/Bay	impaired glucose tolerance	J:211773
Pdx1^{tm1b(EUCOMM)Wtsi}/Pdx1^{tm1b(EUCOMM)Wtsi} C57BL/6N-Pdx1^{tm1b(EUCOMM)Wtsi}/Bay	preweaning lethality, complete penetrance	J:211773
Pdx1^tm1Cvw/Pdx1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal pancreatic beta cell physiology	J:165268
	abnormal pancreatic islet size	J:165268
	decreased insulin secretion	J:165268
	decreased pancreatic beta cell number	J:165268
	disorganized pancreatic islets	J:165268
	normal endocrine/exocrine gland phenotype	J:165268
	impaired glucose tolerance	J:165268
	increased circulating glucose level	J:165268
	increased pancreatic beta cell apoptosis	J:165268
	small pancreatic islets	J:165268
Pdx1^tm1Cvw/Pdx1^tm1.1Stof involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6	decreased pancreas weight	J:152582
	hyperglycemia	J:152582
	small pancreas	J:152582
Pdx1^tm1Cvw/Pdx1^tm1Cvw involves: 129S1/Sv * 129X1/SvJ * Black Swiss	abnormal bile duct development	J:32017
	abnormal duodenum morphology	J:32017
	abnormal foregut morphology	J:32017
	abnormal liver development	J:32017
	abnormal pancreatic acinar cell morphology	J:32017
	abnormal pancreatic beta cell differentiation	J:32017
	abnormal pancreatic duct morphology	J:32017
	abnormal pancreatic islet morphology	J:32017
	abnormal pyloric sphincter morphology	J:32017
	abnormal small intestine morphology	J:32017
	abnormal stomach morphology	J:32017
	absent Brunner's glands	J:32017
	absent pancreas	J:32017
	decreased body weight	J:32017
	dehydration	J:32017
	postnatal growth retardation	J:32017
	postnatal lethality, complete penetrance	J:32017
	sparse hair	J:32017
	thin skin	J:32017
Pdx1^tm1Cvw/Pdx1^tm4Cvw Tg(Ins2-cre)25Mgn/0 involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * DBA	abnormal pancreas morphology	J:130389
	decreased circulating insulin level	J:130389
	decreased pancreatic beta cell number	J:130389
	decreased pancreatic beta cell proliferation	J:130389
	disorganized pancreatic islets	J:130389
	impaired glucose tolerance	J:130389
	increased circulating glucose level	J:130389
	increased pancreatic alpha cell number	J:130389
	increased pancreatic alpha cell proliferation	J:130389
	increased pancreatic delta cell number	J:130389
Pdx1^tm1Egs/Pdx1⁺ involves: 129S1/Sv	no abnormal phenotype detected	J:110137
Pdx1^tm1Heed/Pdx1^tm1Heed Tg(Ins2-cre)1Heed/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal pancreatic beta cell physiology	J:48516
	abnormal pancreatic islet morphology	J:48516
	decreased pancreatic beta cell number	J:48516
	disorganized pancreatic islets	J:48516
	increased circulating glucose level	J:48516
	increased pancreatic alpha cell number	J:48516
	increased urine glucose level	J:48516
Pdx1^tm1Macd/Pdx1⁺ involves: 129S1/Sv * 129X1/SvJ	impaired glucose tolerance	J:79206, J:101742
Pdx1^tm1Macd/Pdx1^tm1Macd involves: 129S1/Sv * 129X1/SvJ	normal liver/biliary system phenotype	J:151981
Pdx1^tm1Ted/Pdx1⁺ involves: 129P2/OlaHsd	abnormal pancreatic beta cell apoptosis	J:82969
	abnormal pancreatic islet cell apoptosis	J:82969
	abnormal pancreatic islet morphology	J:82969
	decreased insulin secretion	J:82969
	decreased pancreatic beta cell mass	J:82969
	decreased pancreatic islet number	J:82969
	impaired glucose tolerance	J:48516, J:82969
	increased circulating glucose level	J:82969
	pancreas inflammation	J:82969
	small pancreatic islets	J:82969
Pdx1^tm1Ted/Pdx1^tm1Ted involves: 129P2/OlaHsd	abnormal pancreas development	J:33133
	abnormal small intestine placement	J:20779
	absent pancreas	J:20779
	decreased body size	J:20779
	normal immune system phenotype	J:20779
	increased circulating glucose level	J:20779
	normal liver/biliary system phenotype	J:20779
	postnatal lethality, complete penetrance	J:20779
Pdx1^tm2Cvw/Pdx1⁺ involves: 129/Sv * Black Swiss	decreased insulin secretion	J:97234
Pdx1^tm2Cvw/Pdx1⁺ involves: 129/Sv * Black Swiss	impaired glucose tolerance	J:97234
Pdx1^tm2Cvw/Pdx1⁺ involves: 129S1/Sv * 129X1/SvJ * Black Swiss	abnormal mitochondrial physiology	J:75664
	abnormal pancreatic beta cell physiology	J:75664
	abnormal tricarboxylic acid cycle	J:75664
	decreased amylin secretion	J:75664
	decreased insulin secretion	J:75664
	normal homeostasis/metabolism phenotype	J:75664
	impaired glucose tolerance	J:75664
	increased glucagon secretion	J:75664
Pdx1^tm2Cvw/Pdx1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA	impaired glucose tolerance	J:104617
Pdx1^tm2Cvw/Pdx1^tm2Cvw involves: 129S1/Sv * 129X1/SvJ * Black Swiss	abnormal bile duct development	J:32017
	abnormal duodenum morphology	J:32017
	abnormal foregut morphology	J:32017
	abnormal liver development	J:32017
	abnormal pancreatic acinar cell morphology	J:32017
	abnormal pancreatic beta cell differentiation	J:32017
	abnormal pancreatic duct morphology	J:32017
	abnormal pancreatic islet morphology	J:32017
	abnormal pyloric sphincter morphology	J:32017
	abnormal small intestine morphology	J:32017
	abnormal stomach morphology	J:32017
	absent pancreas	J:32017
	decreased body weight	J:32017
	dehydration	J:32017
	postnatal growth retardation	J:32017
	postnatal lethality, complete penetrance	J:32017
	sparse hair	J:32017
	thin skin	J:32017
Pdx1^tm2Cvw/Pdx1^tm2Cvw involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA	abnormal intestine morphology	J:104617
	abnormal stomach enteroendocrine cell morphology	J:104617
	abnormal stomach pyloric region morphology	J:104617
	distended stomach	J:104617
Pdx1^tm2Cvw/Pdx1^tm3Cvw involves: 129/Sv * C57BL/6 * DBA * FVB/N	abnormal enteroendocrine cell morphology	J:104617
	abnormal pancreas development	J:104617
	dehydration	J:104617
	exocrine pancreatic insufficiency	J:104617
	postnatal growth retardation	J:104617
	postnatal lethality, complete penetrance	J:104617
Pdx1^tm3Cvw/Pdx1⁺ involves: 129S6/SvEvTac * C57BL/6 * DBA * FVB/N	decreased circulating insulin level	J:104617
	disorganized pancreatic islets	J:104617
	impaired glucose tolerance	J:104617
	increased circulating glucose level	J:104617
	increased pancreatic alpha cell number	J:104617
	increased PP cell number	J:104617
Pdx1^tm3Cvw/Pdx1^tm3Cvw involves: 129S6/SvEvTac * C57BL/6 * DBA * FVB/N	abnormal enteroendocrine cell morphology	J:104617
	abnormal pancreas development	J:104617
	postnatal lethality, complete penetrance	J:104617
Pdx1^tm4Cvw/Pdx1^tm4Cvw involves: 129S1/Sv * 129X1/SvJ * Black Swiss	no abnormal phenotype detected	J:130389

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