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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pdx1
pancreatic and duodenal homeobox 1
MGI:102851
38 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Insrtm1Khn/Insrtm1Khn
Pdx1tm1Ted/Pdx1+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S4/SvJae * C57BL/6 * DBA/2 		decreased pancreatic beta cell mass J:92861
Krastm5Tyj/Kras+
Pdx1tm1.1(flpo)Most/Pdx1+
Trp53tm1.1Dgk/Trp53+
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * Black Swiss * C57BL/6 		increased pancreatic ductal adenocarcinoma incidence J:248550
increased pancreatic intraepithelial neoplasia incidence J:248550
premature death J:248550
Krastm5Tyj/Kras+
Pdx1tm1.1(flpo)Most/Pdx1+
Trp53tm1.1Dgk/Trp53tm1.1Dgk
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * Black Swiss * C57BL/6 		increased pancreatic ductal adenocarcinoma incidence J:248550
increased pancreatic intraepithelial neoplasia incidence J:248550
premature death J:248550
Neurog3tm1.1(cre/ERT)Ggu/Neurog3+
Pdx1tm1Macd/Pdx1+
Tg(tetO-Myt1)2Ggu/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ 		abnormal pancreatic islet morphology J:136131
Nkx6-1tm1.1Msan/Nkx6-1+
Pdx1tm1Cvw/Pdx1+
Tg(Neurog3-cre)C1Able/0
involves: 129/Sv * C57BL/6 * SJL 		abnormal pancreatic islet morphology J:195153
decreased pancreatic beta cell number J:195153
increased pancreatic alpha cell number J:195153
Pdx1tm1Cvw/Pdx1+
Pbx1tm1Mlc/Pbx1+
involves: 129S6/SvEvTac * C57BL/6 		decreased insulin secretion J:75811
disorganized pancreatic islets J:75811
hyperglycemia J:75811
impaired glucose tolerance J:75811
increased insulin sensitivity J:75811
increased urine glucose level J:75811
weight loss J:75811
Pdx1tm1Cvw/Pdx1+
SpopGt(BGB118)Byg/Spop+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal pancreatic beta cell morphology J:165268
abnormal pancreatic beta cell physiology J:165268
decreased insulin secretion J:165268
disorganized pancreatic islets J:165268
normal endocrine/exocrine gland phenotype J:165268
improved glucose tolerance J:165268
increased circulating glucose level J:165268
Pdx1tm1Egs/Pdx1+
Stk11tm1.1Gne/Stk11tm1.1Gne
involves: 129S1/Sv * C57BL/6N 		increased cell proliferation J:195229
pancreas cyst J:195229
Pdx1tm1Macd/Pdx1+
Tg(tetO-Neurog3)8Ggu/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal pancreas development J:136131
Pdx1tm1Macd/Pdx1+
Tg(tetO-Myt1)2Ggu/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal pancreas development J:136131
Pdx1tm1Macd/Pdx1+
Tg(tetO-Sox17,-EGFP)1Jaw/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal digestive system morphology J:151981
abnormal endocrine pancreas morphology J:151981
abnormal pancreas development J:151981
abnormal pancreas morphology J:151981
abnormal stomach morphology J:151981
normal digestive/alimentary phenotype J:151981
exocrine pancreas hyperplasia J:151981
normal liver/biliary system phenotype J:151981
pancreatic acinar hypoplasia J:151981
small pancreas J:151981
stomach epithelial hyperplasia J:151981
Pdx1tm1Macd/Pdx1tm1Macd
Tg(tetO-Ipf1,EGFP)956.6Macd/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal pancreas development J:79206
abnormal pancreatic beta cell morphology J:101742
decreased circulating glucose level J:101742
decreased insulin secretion J:101742
impaired glucose tolerance J:79206, J:101742
increased cell proliferation J:101742
increased circulating glucose level J:79206
increased glucagon secretion J:101742
small pancreatic islets J:101742
Pdx1tm1Macd/Pdx1tm1Macd
Tg(tetO-Ipf1,lacZ)958.1Macd/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal pancreas development J:103522
absent pancreas J:103522
impaired glucose tolerance J:103522
Pdx1tm2Cvw/Pdx1+
Slc2a4tm1Mch/Slc2a4+
involves: 129/Sv * Black Swiss * C57BL/6 * SJL 		decreased circulating insulin level J:97234
decreased insulin secretion J:97234
impaired glucose tolerance J:97234
increased circulating glucose level J:97234
pancreatic islet hyperplasia J:97234
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11/12/2024
MGI 6.24 		The Jackson Laboratory