Fosl2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Fosl2
fos-like antigen 2
MGI:102858

71 phenotypes from 5 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Col1a1^{tm2(tetO-Fosl2,-DsRed)Wag}/Col1a1⁺ Tg(Cebpb-tTA)5Bjd/0 involves: 129S4/SvJae * C57BL/6 * NMRI	decreased liver triglyceride level	J:210545
	decreased susceptibility to diet-induced hepatic steatosis	J:210545
	normal homeostasis/metabolism phenotype	J:213764
Col1a1^{tm2(tetO-Fosl2,-DsRed)Wag}/Col1a1⁺ Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 involves: 129S4/SvJae * C57BL/6 * CD-1	abnormal osteoblast morphology	J:211215
	abnormal osteoblast physiology	J:211215
	abnormal osteoclast morphology	J:211215
	normal adipose tissue phenotype	J:211215
	decreased body weight	J:211215
	decreased circulating adiponectin level	J:211215
	decreased circulating glucose level	J:211215
	decreased circulating insulin level	J:211215
	decreased gonadal fat pad weight	J:211215
	decreased insulin secretion	J:211215
	improved glucose tolerance	J:211215
	increased bone ossification	J:211215
	increased bone trabecula number	J:211215
	increased bone volume	J:211215
	increased circulating osteocalcin level	J:211215
	increased insulin sensitivity	J:211215
	increased trabecular bone thickness	J:211215
Fosl2^tm1Wag/Fosl2^tm1Wag involves: 129 * C57BL/6	abnormal cartilage morphology	J:94393
	abnormal chondrocyte differentiation	J:94393
	abnormal long bone epiphysis morphology	J:94393
	abnormal skeleton development	J:94393
	abnormal vertebrae development	J:94393
	abnormal vertebrae morphology	J:94393
	abnormal vertebral arch morphology	J:94393
	decreased width of hypertrophic chondrocyte zone	J:94393
	delayed endochondral bone ossification	J:94393
	postnatal growth retardation	J:94393
	postnatal lethality, complete penetrance	J:94393
Fosl2^tm2.1Wag/Fosl2^tm2.1Wag involves: 129P2/OlaHsd	decreased body size	J:125028
	postnatal growth retardation	J:125028
	postnatal lethality, complete penetrance	J:125028
Fosl2^tm2.1Wag/Fosl2^tm2.1Wag involves: 129P2/OlaHsd * C57BL/6	abnormal osteoclast differentiation	J:137646
	abnormal osteoclast morphology	J:137646
	abnormal osteoclast physiology	J:137646
	decreased bone mineral density	J:137646
	hypoxia	J:137646
	increased bone resorption	J:137646
	increased osteoclast cell number	J:137646
Fosl2^tm2Wag/Fosl2^tm2Wag Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal osteoclast differentiation	J:137646
Fosl2^tm2Wag/Fosl2^tm2Wag Meox2^tm1(cre)Sor/Meox2⁺ involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6	normal skeleton phenotype	J:137646
Fosl2^tm2Wag/Fosl2^tm2Wag Tg(COL2A1-cre)1Wag/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal chondrocyte morphology	J:94393
	decreased body size	J:94393
	decreased body weight	J:94393
	decreased bone mineralization	J:94393
	decreased width of hypertrophic chondrocyte zone	J:94393
	kyphosis	J:94393
	postnatal growth retardation	J:94393
	postnatal lethality, complete penetrance	J:94393
Fosl2^tm2Wag/Fosl2^tm2Wag Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 involves: 129P2/OlaHsd * C57BL/6 * CD-1	abnormal osteoblast morphology	J:211215
	abnormal osteoblast physiology	J:211215
	abnormal osteoclast morphology	J:211215
	normal adipose tissue phenotype	J:211215
	decreased bone ossification	J:211215
	decreased bone trabecula number	J:211215
	decreased bone volume	J:211215
	decreased circulating glucose level	J:211215
	decreased circulating osteocalcin level	J:211215
	decreased trabecular bone thickness	J:211215
	impaired glucose tolerance	J:211215
	increased body weight	J:211215
	increased gonadal fat pad weight	J:211215
	insulin resistance	J:211215
Tg(H2-K-Fosl2,-EGFP)13Wag/0 B6.Cg-Tg(H2-K-Fosl2,-EGFP)13Wag	abnormal lung vasculature morphology	J:238723
	lung inflammation	J:238723
	pulmonary fibrosis	J:238723
	vascular smooth muscle hyperplasia	J:238723
Tg(H2-K-Fosl2,-EGFP)13Wag/0 either: 129.Cg-Tg(H2-K-Fosl2,-EGFP)13Wag or B6.Cg-Tg(H2-K-Fosl2,-EGFP)13Wag	abnormal lung morphology	J:139032
	abnormal pulmonary artery morphology	J:139032
	cardiac fibrosis	J:139032
	esophagus fibrosis	J:139032
	hunched posture	J:139032
	increased bone mass	J:139032
	increased fibrosarcoma incidence	J:139032
	increased lung weight	J:139032
	liver fibrosis	J:139032
	premature death	J:139032
	pulmonary fibrosis	J:139032
	normal renal/urinary system phenotype	J:139032
	respiratory distress	J:139032
	skin fibrosis	J:139032
	stomach fibrosis	J:139032
	tachypnea	J:139032
	thymus fibrosis	J:139032

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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