Ube2b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ube2b
ubiquitin-conjugating enzyme E2B
MGI:102944

34 phenotypes from 3 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ube2b^{tm1a(EUCOMM)Wtsi}/Ube2b⁺ C57BL/6N-Ube2b^{tm1a(EUCOMM)Wtsi}/Ics	abnormal behavior	J:165965
	decreased circulating triglyceride level	J:165965
	increased circulating triglyceride level	J:165965
Ube2b^{tm1b(EUCOMM)Wtsi}/Ube2b⁺ C57BL/6N-Ube2b^{tm1b(EUCOMM)Wtsi}/Ics	abnormal coat appearance	J:211773
	abnormal gait	J:211773
	decreased basophil cell number	J:211773
	decreased neutrophil cell number	J:211773
	enlarged heart	J:211773
	increased leukocyte cell number	J:211773
	increased lymphocyte cell number	J:211773
	limb grasping	J:211773
Ube2b^{tm1b(EUCOMM)Wtsi}/Ube2b^{tm1b(EUCOMM)Wtsi} C57BL/6N-Ube2b^{tm1b(EUCOMM)Wtsi}/Ics	preweaning lethality, incomplete penetrance	J:211773
Ube2b^tm1Jhjh/Ube2b^tm1Jhjh either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB/N)	abnormal chiasmata formation	J:81811
	abnormal male meiosis	J:81811
	abnormal spermatocyte morphology	J:81811
	abnormal spermatogenesis	J:81811
	abnormal synaptonemal complex	J:81811
	abnormal telomere morphology	J:81811
	increased male germ cell apoptosis	J:81811
	male infertility	J:81811
Ube2b^tm1Jhjh/Ube2b^tm1Jhjh involves: 129 * C57BL/6	abnormal manchette morphology	J:83771
	abnormal outer dense fiber morphology	J:83771
	abnormal sperm fibrous sheath morphology	J:83771
	abnormal sperm flagellum morphology	J:83771
	abnormal spermatid morphology	J:83771
	ectopic manchette	J:83771
Ube2b^tm1Jhjh/Ube2b^tm1Jhjh involves: 129P2/OlaHsd	abnormal double-strand DNA break repair	J:177475
Ube2b^tm1Jhjh/Ube2b^tm1Jhjh involves: 129P2/OlaHsd * FVB/NJ	abnormal sperm head morphology	J:35244
	abnormal sperm midpiece morphology	J:35244
	abnormal spermatocyte morphology	J:35244
	abnormal spermatogenesis	J:35244
	asthenozoospermia	J:35244
	decreased testis weight	J:35244
	increased male germ cell apoptosis	J:35244
	male infertility	J:35244
	oligozoospermia	J:35244
	normal reproductive system phenotype	J:35244
	teratozoospermia	J:35244

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24