Ube2b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ube2b
ubiquitin-conjugating enzyme E2B
MGI:102944

34 phenotypes from 3 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ube2b^{tm1a(EUCOMM)Wtsi}/Ube2b⁺ C57BL/6N-Ube2b^{tm1a(EUCOMM)Wtsi}/Ics	abnormal behavior	J:165965
	decreased circulating triglyceride level	J:165965
	increased circulating triglyceride level	J:165965
Ube2b^{tm1b(EUCOMM)Wtsi}/Ube2b⁺ C57BL/6N-Ube2b^{tm1b(EUCOMM)Wtsi}/Ics	abnormal coat appearance	J:211773
	abnormal gait	J:211773
	decreased basophil cell number	J:211773
	decreased neutrophil cell number	J:211773
	enlarged heart	J:211773
	increased leukocyte cell number	J:211773
	increased lymphocyte cell number	J:211773
	limb grasping	J:211773
Ube2b^{tm1b(EUCOMM)Wtsi}/Ube2b^{tm1b(EUCOMM)Wtsi} C57BL/6N-Ube2b^{tm1b(EUCOMM)Wtsi}/Ics	preweaning lethality, incomplete penetrance	J:211773
Ube2b^tm1Jhjh/Ube2b^tm1Jhjh either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB/N)	abnormal chiasmata formation	J:81811
	abnormal male meiosis	J:81811
	abnormal spermatocyte morphology	J:81811
	abnormal spermatogenesis	J:81811
	abnormal synaptonemal complex	J:81811
	abnormal telomere morphology	J:81811
	increased male germ cell apoptosis	J:81811
	male infertility	J:81811
Ube2b^tm1Jhjh/Ube2b^tm1Jhjh involves: 129 * C57BL/6	abnormal manchette morphology	J:83771
	abnormal outer dense fiber morphology	J:83771
	abnormal sperm fibrous sheath morphology	J:83771
	abnormal sperm flagellum morphology	J:83771
	abnormal spermatid morphology	J:83771
	ectopic manchette	J:83771
Ube2b^tm1Jhjh/Ube2b^tm1Jhjh involves: 129P2/OlaHsd	abnormal double-strand DNA break repair	J:177475
Ube2b^tm1Jhjh/Ube2b^tm1Jhjh involves: 129P2/OlaHsd * FVB/NJ	abnormal sperm head morphology	J:35244
	abnormal sperm midpiece morphology	J:35244
	abnormal spermatocyte morphology	J:35244
	abnormal spermatogenesis	J:35244
	asthenozoospermia	J:35244
	decreased testis weight	J:35244
	increased male germ cell apoptosis	J:35244
	male infertility	J:35244
	oligozoospermia	J:35244
	normal reproductive system phenotype	J:35244
	teratozoospermia	J:35244

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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