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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Foxn1
forkhead box N1
MGI:102949
160 phenotypes from 22 alleles in 36 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Foxn1nu-2J/Foxn1nu-2J
B6(SJL)-Foxn1nu-2J/GrsrJ 		abnormal hair follicle bulb morphology J:192383
abnormal vibrissa morphology J:192383
absent vibrissae J:192383
athymia J:192383
brittle hair J:192383
curly vibrissae J:192383
decreased body size J:192383
decreased litter size J:192383
hairless J:192383
increased or absent threshold for auditory brainstem response J:192383
premature death J:192383
reduced female fertility J:192383
short vibrissae J:192383
sparse vibrissae J:192383
underdeveloped hair follicles J:192383
wrinkled skin J:192383
Foxn1nu-Bc/Foxn1nu-Bc
involves: SELH/Bc 		abnormal hair growth J:65317
hairless J:65317
Foxn1nu-StL/Foxn1nu-StL
involves: C57BL/6 		absent T cells J:63313
athymia J:63313
hairless J:63313
Foxn1nu-StL/Foxn1tm1Tbo
involves: 129S1/Sv * C57BL/6 		abnormal thymus development J:63313
athymia J:63313
Foxn1nu-str/Foxn1nu-str
AKR/J-Foxn1nu-str/J 		abnormal humoral immune response J:30715
abnormal immune system cell morphology J:30715
abnormal immune system morphology J:24755
abnormal immune system organ morphology J:30715
abnormal immune system physiology J:30715
abnormal Peyer's patch germinal center morphology J:30715
abnormal Peyer's patch morphology J:30715
athymia J:24755
cachexia J:30715
decreased immunoglobulin level J:30715
decreased incidence of tumors by chemical induction J:43880
decreased lymphocyte cell number J:30715
decreased lymphoma incidence J:30715
decreased T cell number J:30715
hairless J:24755
increased eosinophil cell number J:30715
increased granulocyte number J:30715
increased length of allograft survival J:30715
increased neutrophil cell number J:30715
increased sarcoma incidence J:30715
lymph node hypoplasia J:30715
premature death J:30715
spleen hypoplasia J:30715
Foxn1nu-Y/Foxn1nu-Y
101/HY-Foxn1nu-Y 		abnormal thymus development J:4060
absent T cells J:4060
athymia J:4060, J:29022
decreased body weight J:4060
hairless J:4060
postnatal lethality, incomplete penetrance J:4060
Foxn1nu/Foxn1+
B6N.Cg-Foxn1nu 		small thymus J:7330
Foxn1nu/Foxn1+
C3N.Cg-Foxn1nu 		small thymus J:7330
Foxn1nu/Foxn1+
C.Cg-Foxn1nu 		small thymus J:7330
Foxn1nu/Foxn1+
involves: BALB/c 		blepharitis J:12543
cornea vascularization J:12543
increased incidence of corneal inflammation J:12543
increased susceptibility to Herpesvirales infection J:12543
Foxn1nu/Foxn1+
NFS.Cg-Foxn1nu 		abnormal thymus morphology J:7330
small thymus J:7330
Foxn1nu/Foxn1nu
B6.Cg-Foxn1nu 		abnormal compact bone morphology J:145330
abnormal trabecular bone morphology J:145330
increased bone mineral density J:145330
Foxn1nu/Foxn1nu
B6NTac.Cg-Foxn1nu/Tac 		decreased susceptibility to parasitic infection J:64283
Foxn1nu/Foxn1nu
involves: BALB/c 		abnormal circulating cytokine level J:50903
abnormal nail morphology J:173664
ascites J:40405
blepharitis J:12543
chromosomal instability J:40405
decreased circulating alanine transaminase level J:50903
decreased circulating interleukin-2 level J:50903
decreased circulating interleukin-6 level J:50903
decreased circulating tumor necrosis factor level J:50903
decreased interferon-gamma secretion J:50903
decreased susceptibility to bacterial infection J:50903
deformed nails J:173664
increased plasmacytoma incidence J:40405
increased susceptibility to Herpesvirales infection J:12543
increased susceptibility to Herpesvirales infection induced morbidity/mortality J:12543
short nails J:173664
Foxn1nu/Foxn1nu
involves: C57BL/10 		abnormal muscle morphology J:95776
decreased skeletal muscle fiber size J:95776
decreased skeletal muscle mass J:95776
Foxn1nu/Foxn1nu
involves: C57BL/10Sn * C57BR/cd 		abnormal thymus development J:7898
Foxn1nu/Foxn1nu
involves: CBA 		abnormal lymph node morphology J:202808
abnormal spleen physiology J:202299
abnormal T cell activation J:202299
decreased leukocyte cell number J:202299
decreased lymphocyte cell number J:202299
decreased T cell number J:202808
increased length of allograft survival J:202299
Foxn1nu/Foxn1nu
involves: CD-1 		abnormal circulating gonadotropin level J:106251
athymia J:106251
decreased circulating follicle stimulating hormone level J:106251
decreased circulating luteinizing hormone level J:106251
normal endocrine/exocrine gland phenotype J:106251
Foxn1nu/Foxn1nu
involves: NIH Swiss 		premature death J:5583
Foxn1nu/Foxn1nu
involves: NMRI 		abnormal coat/ hair morphology J:94187
abnormal corneocyte morphology J:466
abnormal cutaneous collagen fibril morphology J:466
abnormal embryonic tissue morphology J:6363
abnormal epidermal layer morphology J:466
abnormal epidermis stratum basale morphology J:466
abnormal epidermis stratum corneum morphology J:466
abnormal epidermis stratum granulosum morphology J:466
abnormal hair cortex keratinization J:466
abnormal hair cortex morphology J:466
abnormal hair cuticle J:466
abnormal hair follicle inner root sheath morphology J:466
abnormal hair follicle morphology J:466
abnormal hair shaft morphology J:466
abnormal nail matrix morphology J:94187
abnormal nail morphology J:94187
abnormal nail plate morphology J:94187
abnormal thymus development J:6363
deformed nails J:94187
normal endocrine/exocrine gland phenotype J:6363
nail dystrophy J:94187
reduced hair shaft melanin granule number J:466
short nails J:94187
Foxn1nu/Foxn1nu
Not Specified 		abnormal estrous cycle J:5043
abnormal liver morphology J:5043
abnormal lymph node T cell domain morphology J:202296
abnormal Peyer's patch germinal center morphology J:202296
abnormal spleen morphology J:202296
abnormal splenic cell ratio J:202296
abnormal thymus morphology J:202297
abnormal venule morphology J:202296
absent vibrissae J:5043
asthenozoospermia J:5043
athymia J:5059, J:202296
coiled sperm flagellum J:5043
decreased body size J:5043
decreased body weight J:5043
decreased leukocyte cell number J:5059
female infertility J:5043
hairless J:5043, J:30772
impaired spatial learning J:90695
postnatal growth retardation J:5043
postnatal lethality, incomplete penetrance J:5043
premature death J:5043, J:30772
reduced male fertility J:5043
short vibrissae J:5043
small ovary J:5043
small spleen J:202296
thin skin J:5043
wavy vibrissae J:5043
Foxn1nu/Foxn1nu
NU/J 		abnormal nail matrix morphology J:94187
abnormal nail morphology J:94187
abnormal nail plate morphology J:94187
nail dystrophy J:94187
Foxn1nu/Foxn1nu
Tg(Foxn1)E1Hon/0
involves: CD-1 		athymia J:33866
hairless J:33866
Foxn1nu/Foxn1nu
Tg(Foxn1)G2Hon/0
involves: CD-1 		hairless J:33866
infertility J:33866
Foxn1nu/Foxn1tm1.1Dmsu
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129/Sv * C57BL/6 * CBA * SJL 		abnormal thymus epithelium morphology J:159773
decreased thymocyte number J:159773
increased thymocyte apoptosis J:159773
Foxn1sepe/Foxn1sepe
BALB/c-Foxn1sepe 		athymia J:227974
hairless J:227974
Foxn1tm1.1(KOMP)Vlcg/Foxn1tm1.1(KOMP)Vlcg
C57BL/6N-Foxn1tm1.1(KOMP)Vlcg/Tcp 		abnormal skin morphology J:211773
abnormal thymus morphology J:211773
athymia J:211773
preweaning lethality, incomplete penetrance J:211773
Foxn1tm1.1Cbln/Foxn1+
involves: 129P2/OlaHsd * C57BL/6 		thymus hyperplasia J:177992
Foxn1tm1.1Cbln/Foxn1+
Tg(Zp3-cre)3Mrt/?
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N 		normal immune system phenotype J:177992
Foxn1tm1.1Cbln/Foxn1tm1.1Cbln
involves: 129P2/OlaHsd * C57BL/6 		abnormal lymphocyte cell number J:177992
decreased single-positive T cell number J:177992
increased DN1 thymic pro-T cell number J:177992
increased double-positive T cell number J:177992
thymus hypoplasia J:177992
Foxn1tm1.1Cbln/Foxn1tm1Tbo
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 		abnormal hair growth J:177992
absent T cells J:177992
small thymus J:177992
Foxn1tm1.1Cbln/Foxn1tm1Tbo
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 		normal immune system phenotype J:177992
Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu
involves: 129/Sv * C57BL/6 * SJL 		no abnormal phenotype detected J:159773
Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129/Sv * C57BL/6 * CBA * SJL 		abnormal thymus morphology J:159773
decreased double-positive T cell number J:159773
decreased thymocyte number J:159773
small thymus J:159773
thymus atrophy J:159773
Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu
Tg(KRT5-cre/ERT2)2Ipc/0
involves: 129/Sv * C57BL/6 * SJL 		abnormal thymus corticomedullary boundary morphology J:159773
abnormal thymus medulla morphology J:159773
decreased thymocyte number J:159773
small thymus J:159773
thymus atrophy J:159773
Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu
Tg(KRT18-cre/ERT2)1Rgo/0
involves: 129/Sv * C57BL/6 * FVB/N * SJL 		normal immune system phenotype J:159773
Foxn1tm1Dmsu/Foxn1tm1Dmsu
involves: 129/Sv * C57BL/6 		athymia J:159773
hairless J:159773
Foxn1tm1Nrm/Foxn1+
involves: 129X1/SvJ * C57BL/6J 		no abnormal phenotype detected J:86255
Foxn1tm1Nrm/Foxn1tm1Nrm
involves: 129X1/SvJ * C57BL/6J 		abnormal CD4-positive, alpha beta T cell morphology J:86255
abnormal CD8-positive, alpha beta T cell morphology J:86255
abnormal T cell differentiation J:86255
abnormal thymus development J:86255
abnormal thymus epithelium morphology J:86255
absent thymus cortex J:86255
absent thymus medulla J:86255
decreased CD4-positive, alpha-beta T cell number J:86255
decreased double-negative T cell number J:86255
decreased double-positive T cell number J:86255
decreased T cell number J:86255
decreased thymocyte number J:86255
normal integument phenotype J:86255
small thymus J:86255
thymus cyst J:86255
Foxn1tm1Tbo/Foxn1tm1Tbo
involves: 129S1/Sv 		abnormal hair follicle development J:61394
abnormal leukocyte cell number J:33796
abnormal thymus development J:33796
abnormal thymus epithelium morphology J:177992
abnormal thymus morphology J:33796
absent T cells J:33796
athymia J:33796
hairless J:33796
increased B cell number J:33796
Foxn1tm2Nrm/Foxn1tm2Nrm
either: (involves: 129/Sv) or (involves: C57BL/6) 		normal immune system phenotype J:125817
Foxn1tm2Tbo/Foxn1tm2Tbo
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		hairless J:110046
Foxn1tm2Tbo/Foxn1tm2Tbo
Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		increased T cell number J:110046
Foxn1tm3(cre)Nrm/Foxn1tm3(cre)Nrm
either: (involves: 129/Sv) or (involves: C57BL/6) 		normal immune system phenotype J:125817
Foxn1tw/Foxn1tw
involves: 129 * C57BL/6 		abnormal skin pigmentation J:85194
hairless J:85194
underdeveloped hair follicles J:85194
Gt(ROSA)26Sortm1(CAG-Foxn1/ERT2,-GFP)Cbln/Gt(ROSA)26Sor+
Foxn1tm3(cre)Nrm/Foxn1+
involves: 129P2/OlaHsd * C57BL/6 		abnormal thymus involution J:208852
normal endocrine/exocrine gland phenotype J:208852
increased T cell number J:208852
Tg(Foxn1)1Jlb/0
involves: C57BL/6 * DBA 		absent eyelids J:56641
decreased body size J:56641
flaky skin J:56641
impaired skin barrier function J:56641
neonatal lethality, complete penetrance J:56641
shiny skin J:56641
tight skin J:56641
Tg(Foxn1)6Jlb/0
involves: C57BL/6 * DBA 		alopecia J:56641
curly vibrissae J:56641
decreased birth body size J:56641
delayed hair appearance J:56641
hydronephrosis J:56641
kinked vibrissae J:56641
loss of vibrissae J:56641
premature death J:56641
scaly muzzle J:56641
short hair J:56641
sparse hair J:56641
underdeveloped hair follicles J:56641
ureter urothelium hyperplasia J:56641
waved hair J:56641
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory