Cdk7 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cdk7
cyclin dependent kinase 7
MGI:102956

34 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst} involves: 129S2/SvPas * C57BL/6 * SJL	absent fibroblast proliferation	J:183925
Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst} Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 involves: 129S/SvPas * 129S2/SvPas * C57BL/6 * SJL	abnormal bone marrow morphology	J:183925
	abnormal coat/hair pigmentation	J:183925
	abnormal hair follicle bulge morphology	J:183925
	abnormal hair follicle morphology	J:183925
	abnormal kidney morphology	J:183925
	abnormal skin morphology	J:183925
	abnormal small intestine crypts of Lieberkuhn morphology	J:183925
	alopecia	J:183925
	decreased bone mineral content	J:183925
	decreased hematopoietic stem cell number	J:183925
	decreased small intestinal villus size	J:183925
	decreased subcutaneous adipose tissue amount	J:183925
	decreased telomere length	J:183925
	decreased trabecular bone mass	J:183925
	kyphosis	J:183925
	nephrocalcinosis	J:183925
	premature aging	J:183925
	thin dermal layer	J:183925
	weight loss	J:183925
Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst} Tg(KRT5-cre)1Tak/0 involves: 129S2/SvPas * C3H * C57BL/6 * SJL	abnormal epidermal layer morphology	J:183925
	abnormal epidermis suprabasal layer morphology	J:183925
	abnormal keratinocyte morphology	J:183925
	abnormal skin development	J:183925
	decreased birth body size	J:183925
	decreased hair follicle number	J:183925
	postnatal lethality, complete penetrance	J:183925
	scaly skin	J:183925
	sparse hair	J:183925
	thin epidermis suprabasal layer	J:183925
Cdk7^{Gt(D032B11)Wrst}/Cdk7^{Gt(D032B11)Wrst} involves: 129S2/SvPas	abnormal inner cell mass apoptosis	J:183925
	abnormal trophoblast layer morphology	J:183925
	embryonic lethality, complete penetrance	J:183925
	increased embryonic tissue cell apoptosis	J:183925

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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