Txk Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Txk
TXK tyrosine kinase
MGI:102960

8 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Itk^tm1Litt/Itk^tm1Litt Txk^tm1Pls/Txk^tm1Pls involves: 129S4/SvJae * 129S6/SvEvTac	decreased CD4-positive, alpha-beta T cell number	J:54449
	decreased single-positive T cell number	J:54449
	decreased T cell proliferation	J:54449
	increased susceptibility to parasitic infection	J:54449
Itk^tm1Ljb/Itk^tm1Ljb Txk^tm1Pls/Txk^tm1Pls B6.129-Txk^tm1Pls Itk^tm1Ljb	abnormal CD8-positive, alpha-beta T cell physiology	J:113408
	increased CD8-positive, alpha-beta T cell number	J:113408
	increased interferon-gamma secretion	J:113408
	increased memory T cell number	J:113408

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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