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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ccr7
C-C motif chemokine receptor 7
MGI:103011
50 phenotypes from 4 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ccr7Gt(hpk)Byg/Ccr7Gt(hpk)Byg
involves: 129 * C57BL/6 		enhanced long-term potentiation J:161269
normal nervous system phenotype J:161269
Ccr7m1Btlr/Ccr7+
C57BL/6J-Ccr7m1Btlr 		decreased macrophage cell number J:221477
Ccr7m1Btlr/Ccr7m1Btlr
C57BL/6J-Ccr7m1Btlr 		decreased macrophage cell number J:221477
increased single-positive T cell number J:221477
Ccr7tm1Dgen/Ccr7tm1Dgen
involves: 129P2/OlaHsd * C57BL/6 		chronic inflammation J:101679
Ccr7tm1Rfor/Ccr7tm1Rfor
B6.129P2(C)-Ccr7tm1Rfor/J 		decreased susceptibility to bacterial infection J:210086
Ccr7tm1Rfor/Ccr7tm1Rfor
B6.129P2-Ccr7tm1Rfor 		abnormal dendritic cell physiology J:183989
abnormal exocrine gland morphology J:110910
abnormal lacrimal gland morphology J:110910
abnormal leukocyte migration J:93960, J:110910
abnormal parotid gland morphology J:110910
abnormal physiological response to xenobiotic J:110910
abnormal submandibular gland morphology J:110910
abnormal thymus cortex morphology J:93960
normal immune system phenotype J:93960
increased inflammatory response J:110910
increased susceptibility to autoimmune disorder J:110910
lacrimal gland inflammation J:110910
parotid gland inflammation J:110910
salivary gland inflammation J:110910
small thymus medulla J:93960
submandibular gland inflammation J:110910
Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 		abnormal dendritic cell physiology J:134784
Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd 		abnormal dendritic cell chemotaxis J:223508
decreased CD11b-high dendritic cell number J:223508
decreased CD103-positive CD11b-low dendritic cell number J:223508
Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c 		abnormal B cell activation J:57976
abnormal class switch recombination J:57976
abnormal dendritic cell physiology J:57976
abnormal humoral immune response J:57976
abnormal leukocyte migration J:57976
abnormal lymph node cortex morphology J:57976
abnormal lymph node germinal center morphology J:57976
abnormal lymph node T cell domain morphology J:57976
abnormal Peyer's patch T cell area morphology J:57976
abnormal spleen marginal sinus morphology J:57976
abnormal spleen periarteriolar lymphoid sheath morphology J:57976
abnormal spleen red pulp morphology J:57976
abnormal T cell physiology J:57976
decreased CD4-positive, alpha-beta T cell number J:57976
decreased dendritic cell number J:57976
decreased IgG3 level J:57976
decreased susceptibility to type IV hypersensitivity reaction J:57976
decreased T cell number J:57976
enlarged spleen J:57976
impaired B cell migration J:57976
increased CD4-positive, alpha-beta T cell number J:57976
increased IgE level J:57976
increased IgG1 level J:57976
increased IgG2a level J:57976
increased T cell number J:57976
small lymph nodes J:57976
small Peyer's patches J:57976
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory