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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Il15
interleukin 15
MGI:103014
76 phenotypes from 7 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Il15m1Hwata/Il15m1Hwata
Not Specified 		abnormal interleukin secretion J:184570
abnormal NK T cell number J:184570
decreased interferon-gamma secretion J:184570
decreased NK cell number J:184570
decreased NK T cell number J:184570
Il15tm1.1Iku/Il15+
B6.Cg-Il15tm1.1Iku 		normal immune system phenotype J:206571
Il15tm1b(EUCOMM)Hmgu/Il15tm1b(EUCOMM)Hmgu
C57BL/6N-Il15tm1b(EUCOMM)Hmgu/H 		enlarged heart J:211773
impaired glucose tolerance J:211773
increased grip strength J:211773
limb grasping J:211773
Il15tm1Imx/Il15tm1Imx
C57BL/6-Il15tm1Imx 		abnormal dendritic cell physiology J:123902
Il15tm1Imx/Il15tm1Imx
C57BL/6-Il15tm1Imx/Tac 		abnormal CD8-positive, alpha-beta T cell differentiation J:111786
abnormal thymus cell ratio J:111786
decreased CD8-positive, alpha-beta T cell number J:111786
Il15tm1Imx/Il15tm1Imx
involves: C57BL/6 		abnormal CD8-positive, alpha-beta T cell physiology J:95221
abnormal cytokine secretion J:97620
abnormal decidualization J:84009
abnormal immune system morphology J:60915
abnormal immune system physiology J:60915
abnormal lymphocyte morphology J:60915
abnormal susceptibility to infection J:60915
abnormal uterine artery morphology J:84009
absent uterine NK cells J:84009
decreased body weight J:84009
decreased CD8-positive, alpha-beta T cell number J:60915, J:113408
decreased CD8-positive, gamma-delta intraepithelial T cell number J:155298
decreased dendritic cell number J:97620
decreased IgG level J:97620
decreased IgM level J:97620
decreased immunoglobulin level J:97620
decreased interferon-gamma secretion J:97620
decreased interleukin-12 secretion J:97620
decreased memory T cell number J:132730
decreased NK cell number J:60915, J:132730, J:142654
decreased regulatory T cell number J:208318
decreased susceptibility to bacterial infection induced morbidity/mortality J:84009
decreased susceptibility to type IV hypersensitivity reaction J:87137
impaired natural killer cell mediated cytotoxicity J:97620
increased susceptibility to Herpesvirales infection induced morbidity/mortality J:97038
increased susceptibility to parasitic infection J:97620
increased susceptibility to Poxviridae infection induced morbidity/mortality J:60915
small lymph nodes J:60915
Tg(ACTA1-Il15)10941Lsq/0
involves: C3H * C57BL/6 		abnormal interleukin level J:145611
normal adipose tissue phenotype J:145611
normal growth/size/body region phenotype J:145611
normal hematopoietic system phenotype J:145611
normal homeostasis/metabolism phenotype J:145611
normal skeleton phenotype J:145611
Tg(ACTA1-Il15*)11650Lsq/0
involves: C3H * C57BL/6 		abnormal body weight J:145611
abnormal interleukin level J:145611
decreased abdominal adipose tissue amount J:145611
decreased body weight J:145611
decreased circulating leptin level J:145611
decreased extensor digitorum longus weight J:145611
decreased fat cell size J:145611
decreased percent body fat/body weight J:145611
normal hematopoietic system phenotype J:145611
increased bone mineral content J:145611
increased circulating interleukin-15 level J:145611
increased lean body mass J:145611
Tg(H2-D-Il15)3304Clgr/?
FVB/N-Tg(H2-D-Il15)3304Clgr 		abnormal inflammatory response J:67478
abnormal liver morphology J:67478
abnormal lung morphology J:67478
abnormal lymphocyte physiology J:67478
abnormal T cell morphology J:67478
abnormal T cell subpopulation ratio J:67478
alopecia J:67478
dermatitis J:67478
enlarged liver J:67478
enlarged lymph nodes J:67478
enlarged spleen J:67478
epidermal hyperplasia J:67478
hair follicle degeneration J:67478
hyperkeratosis J:67478
increased bone marrow cell number J:67478
increased leukemia incidence J:67478, J:97873
increased lymphocyte cell number J:67478
increased memory T cell number J:67478
increased NK cell number J:67478
increased spleen white pulp amount J:67478
premature death J:67478
spontaneous skin ulceration J:67478
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory