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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Stat6
signal transducer and activator of transcription 6
MGI:103034
42 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd28tm1Mak/Cd28tm1Mak
Stat6tm1Gru/Stat6tm1Gru
C.129S2(B6)-Cd28tm1Mak Stat6tm1Gru 		increased susceptibility to parasitic infection J:90987
Fbn1Tsk/Fbn1+
Stat6tm1Gru/Stat6tm1Gru
involves: 129S2/SvPas * C57BL/10 * DBA/2 		decreased interleukin-4 secretion J:57957
emphysema J:57957
normal integument phenotype J:57957
Foxp3tm1Tch/Y
Stat6tm1Gru/Stat6tm1Gru
C.129-Stat6tm1Gru Foxp3tm1Tch 		abnormal cytokine secretion J:117165
normal immune system phenotype J:117165
increased circulating interferon-gamma level J:117165
increased eosinophil cell number J:117165
lethality at weaning, complete penetrance J:117165
normal respiratory system phenotype J:117165
Il4tm1.1Wep/Il4+
Stat6tm1Gru/Stat6tm1Gru
C.129-Stat6tm1Gru Il4tm1.1Wep 		abnormal T-helper 2 cell differentiation J:138827
decreased IgE level J:138827
impaired eosinophil recruitment J:138827
Il4tm1.1Wep/Il4tm1.1Wep
Stat6tm1Gru/Stat6tm1Gru
C.129-Stat6tm1Gru Il4tm1.1Wep 		abnormal T-helper 2 cell differentiation J:138827
decreased IgE level J:138827
impaired eosinophil recruitment J:138827
Nfkbiztm1Aki/Nfkbiz+
Stat6tm1Aki/Stat6tm1Aki
C.129P2-Stat6tm1Aki Nfkbiztm1Aki 		acanthosis J:141704
skin inflammation J:141704
Nfkbiztm1Aki/Nfkbiztm1Aki
Stat6tm1Aki/Stat6tm1Aki
C.129P2-Stat6tm1Aki Nfkbiztm1Aki 		abnormal conjunctival epithelium morphology J:141704
blepharitis J:141704
dermatitis J:141704
epidermal hyperplasia J:141704
eye inflammation J:141704
hyperkeratosis J:141704
skin edema J:141704
skin inflammation J:141704
Socs1tm1Kish/Socs1tm1Kish
Stat6tm1Aki/Stat6tm1Aki
involves: 129P2/OlaHsd * C57BL/6 		decreased body size J:69472
enlarged liver J:69472
normal immune system phenotype J:69472
increased activated T cell number J:69472
liver inflammation J:69472
postnatal growth retardation J:69472
premature death J:69472
thymus atrophy J:69472
Stat4tm1Jni/Stat4tm1Jni
Stat6tm1Jni/Stat6tm1Jni
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 		decreased interleukin-4 secretion J:96338
increased interferon-gamma secretion J:96338
increased susceptibility to autoimmune diabetes J:96338
Stat6tm1Aki/Stat6tm1Aki
Tg(KRT14-CASP1)1Miz/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal circulating histamine level J:78602
decreased IgE level J:78602
decreased IgG1 level J:78602
dermatitis J:78602
excessive scratching J:78602
increased circulating interleukin-18 level J:78602
Stat6tm1Gru/Stat6+
Tg(Scgb1a1-Il13)2Eli/?
involves: 129S2/SvPas * C57BL/6 * CBA 		abnormal lung morphology J:132385
abnormal lung size J:132385
abnormal pulmonary alveolus morphology J:132385
abnormal respiratory system morphology J:132385
abnormal respiratory system physiology J:132385
overexpanded pulmonary alveolus J:132385
respiratory system inflammation J:132385
Stat6tm1Gru/Stat6tm1Gru
Tg(Scgb1a1-Il13)2Eli/?
involves: 129S2/SvPas * C57BL/6 * CBA 		normal respiratory system phenotype J:132385
Stat6tm1Gru/Stat6tm1Gru
Tg(Scgb1a1-Il13)2Eli/?
Tg(Scgb1a1-STAT6)1Erle/?
involves: 129S2/SvPas * C57BL/6 * CBA * FVB 		abnormal respiratory system physiology J:132385
normal respiratory system phenotype J:132385
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory