Stat5b Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Stat5b
signal transducer and activator of transcription 5B
MGI:103035

80 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Akr1c18^tm1Jni/Akr1c18^tm1Jni Stat5b^tm1Hwd/Stat5b^tm1Hwd involves: 129P2/OlaHsd * C57BL/6	normal reproductive system phenotype	J:95560
Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze}/Gt(ROSA)26Sor⁺ Stat5a^tm2Mam Stat5b^tm1Mam/Del(11Stat5a-Stat5b)1Mam Tg(Mx1-cre)1Cgn/0 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA	abnormal CD4-positive T cell differentiation	J:204829
Myf5^tm3(cre)Sor/Myf5⁺ Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Alb1-cre)1Dlr/0 involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N	decreased body length	J:119237
	decreased body weight	J:119237
	decreased circulating insulin-like growth factor I level	J:119237
	decreased lean body mass	J:119237
	increased total body fat amount	J:119237
Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Alb1-cre)7Gsc/0 involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N	decreased body weight	J:121556
Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Alb1-cre)7Gsc/0 involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N	decreased body weight	J:121556
Stat5a^tm1.1Wjl/Stat5a^tm1.1Wjl Stat5b^tm2.1Wjl/Stat5b^tm2.1Wjl involves: 129S6/SvEvTac * C57BL/6J * FVB/N	abnormal leukocyte morphology	J:187325
	abnormal regulatory T cell physiology	J:187325
	abnormal T cell subpopulation ratio	J:187325
	decreased CD8-positive, alpha-beta T cell number	J:187325
	decreased erythrocyte cell number	J:187325
	decreased hematocrit	J:187325
	decreased hemoglobin content	J:187325
	decreased NK cell number	J:187325
	decreased T cell proliferation	J:187325
	increased T cell apoptosis	J:187325
Stat5a^tm1Jni/Stat5a^tm1Jni Stat5b^tm2Jni/Stat5b^tm2Jni either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)	abnormal fat pad morphology	J:77412
	abnormal liver physiology	J:77412
	abnormal myelopoiesis	J:77412
	decreased body weight	J:77412
	decreased corpora lutea number	J:77412
	decreased leukocyte cell number	J:77412
	decreased T cell number	J:77412
	female infertility	J:77412
	increased neutrophil cell number	J:77412
Stat5a^tm1Jni/Stat5a^tm1Jni Stat5b^tm2Jni/Stat5b^tm2Jni involves: 129 * C57BL/6	abnormal mast cell differentiation	J:84889
	abnormal mast cell physiology	J:84889
	absent mast cells	J:84889
	decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:122463
	premature death	J:122463
Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b⁺ involves: 129S6/SvEvTac	abnormal lymphopoiesis	J:258967
Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam involves: 129S6/SvEvTac * Black Swiss	no abnormal phenotype detected	J:92770
Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Myf5^tm3(cre)Sor/Myf5⁺ involves: 129S4/SvJaeSor * 129S6/SvEvTac	decreased body length	J:119237
	decreased body weight	J:119237
	decreased circulating insulin-like growth factor I level	J:119237
	decreased lean body mass	J:119237
	impaired glucose tolerance	J:119237
	increased circulating triglyceride level	J:119237
	increased total body fat amount	J:119237
Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Alb1-cre)7Gsc/0 involves: 129S6/SvEvTac * FVB/N	decreased body weight	J:121556
Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Cd4-cre)1Cwi/0 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2	increased circulating interleukin-17 level	J:120176
	increased interleukin-17 secretion	J:120176
Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Ins2-cre)25Mgn/0 involves: 129S6/SvEvTac * C57BL/6 * DBA	decreased insulin secretion	J:127051
	disorganized pancreatic islets	J:127051
	impaired glucose tolerance	J:127051
	increased circulating free fatty acids level	J:127051
	increased circulating glucose level	J:127051
	increased circulating leptin level	J:127051
	increased total body fat amount	J:127051
	obese	J:127051
Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Lck-cre)I57Jxm/0 involves: 129 * 129S6/SvEvTac * C57BL/6 * ICR	abnormal acute inflammation	J:122463
	abnormal T cell subpopulation ratio	J:122463
	decreased CD8-positive, alpha-beta T cell number	J:122463
	enlarged spleen	J:122463
Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(MMTV-cre)1Mam/0 involves: 129S6/SvEvTac * FVB/N	abnormal mammary gland alveolus morphology	J:153755
	abnormal mammary gland growth during lactation	J:153755
	lactation failure	J:153755
Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(MMTV-cre)1Mam/0 Tg(MMTV-rtTA)1Lach/0 Tg(tetO-Stat5a)#Mam/0 involves: 129S6/SvEvTac * C57BL/6J * FVB/N	normal endocrine/exocrine gland phenotype	J:153755
	normal reproductive system phenotype	J:153755
Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(MMTV-cre)4Mam/0 involves: 129S6/SvEvTac * Black Swiss * FVB	abnormal branching of the mammary ductal tree	J:92770
	abnormal milk ejection	J:92770
Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Mx1-cre)1Cgn/0 involves: 129S6/SvEvTac * C57BL/6 * CBA	abnormal leukopoiesis	J:155489
	abnormal neutrophil differentiation	J:155489
	abnormal neutrophil physiology	J:155489
	anemia	J:155489
	decreased cell proliferation	J:155489
	decreased erythrocyte cell number	J:155489
	decreased hematocrit	J:155489
	decreased hemoglobin content	J:155489
	decreased leukocyte cell number	J:155489
	decreased lymphocyte cell number	J:155489
	decreased monocyte cell number	J:155489
	decreased neutrophil cell number	J:155489
	increased apoptosis	J:155489
Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Nes-cre)1Kln/0 involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL	abnormal fat pad morphology	J:132806
	decreased oxygen consumption	J:132806
	impaired adaptive thermogenesis	J:132806
	impaired glucose tolerance	J:132806
	increased circulating free fatty acids level	J:132806
	increased circulating insulin level	J:132806
	increased circulating leptin level	J:132806
	increased circulating triglyceride level	J:132806
	increased lean body mass	J:132806
	increased percent body fat/body weight	J:132806
	increased total body fat amount	J:132806
	increased total fat pad weight	J:132806
	insulin resistance	J:132806
	obese	J:132806
	polyphagia	J:132806
Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Pdx1-cre)89.1Dam/0 involves: 129S6/SvEvTac * C57BL/6 * CBA	disorganized pancreatic islets	J:127051
	impaired glucose tolerance	J:127051
Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Tek-cre)1Ywa/0 involves: 129S6/SvEvTac * C57BL/6 * SJL	abnormal proerythroblast morphology	J:138904
	anisocytosis	J:138904
	decreased erythrocyte cell number	J:138904
	decreased erythroid progenitor cell number	J:138904
	decreased hematocrit	J:138904
	decreased mean corpuscular hemoglobin	J:138904
	hypochromic microcytic anemia	J:138904
	increased apoptosis	J:138904
	increased circulating iron level	J:138904
	increased liver iron level	J:138904
	increased red blood cell distribution width	J:138904
	microcytosis	J:138904
	poikilocytosis	J:138904
	reticulocytosis	J:138904
Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Wap-cre)11738Mam/0 involves: 129S6/SvEvTac * Black Swiss	abnormal mammary gland alveolus morphology	J:92770
	abnormal mammary gland epithelium physiology	J:92770
	increased mammary gland apoptosis	J:92770
Stat5b^tm1Mam/Stat5b^tm1Mam Tg(MMTV-cre)1Mam/0 Tg(MMTV-rtTA)1Lach/0 Tg(tetO-Stat5a)#Mam/0 involves: 129S6/SvEvTac * C57BL/6J * FVB/N	normal endocrine/exocrine gland phenotype	J:153755
	normal reproductive system phenotype	J:153755

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