Stat5a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Stat5a
signal transducer and activator of transcription 5A
MGI:103036

20 phenotypes from 4 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Stat5a^tm1.1Wjl/Stat5a^tm1.1Wjl involves: 129S6/SvEvTac * C57BL/6J * FVB/N	no abnormal phenotype detected	J:187325
Stat5a^tm1Jni/Stat5a^tm1Jni either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)	abnormal branching of the mammary ductal tree	J:77412
	abnormal fat pad morphology	J:77412
	abnormal mammary gland physiology	J:77412
Stat5a^tm1Mam/Stat5a^tm1Mam C.129S6-Stat5a^tm1Mam	abnormal mast cell differentiation	J:101855
	abnormal mast cell morphology	J:101855
	decreased mast cell number	J:101855
Stat5a^tm1Mam/Stat5a^tm1Mam either: 129S6/SvEvTac-Stat5a^tm1Mam or (involves: 129S6/SvEvTac * NIH Black Swiss)	abnormal branching of the mammary ductal tree	J:64278
	abnormal mammary gland development	J:64278
	abnormal mammary gland growth during lactation	J:64278
	abnormal mammary gland growth during pregnancy	J:64278
	lactation failure	J:64278
Stat5a^tm1Mam/Stat5a^tm1Mam involves: 129S6/SvEvTac	abnormal prostate gland epithelium morphology	J:63495
	abnormal prostate gland physiology	J:63495
	prostate gland cyst	J:63495
Stat5a^tm1Mam/Stat5a^tm1Mam involves: 129S6/SvEvTac * C57BL/6	decreased NK cell number	J:112035
	decreased splenocyte number	J:112035
	impaired natural killer cell mediated cytotoxicity	J:112035
Stat5a^tm2Mam/Stat5a^tm2Mam Tg(Ins2-cre)23Herr/0 involves: 129S6/SvEvTac * C57BL/6J * CBA/J	decreased pancreatic beta cell mass	J:284574
	decreased pancreatic beta cell proliferation	J:284574
	decreased serotonin level	J:284574

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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