Stat4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Stat4
signal transducer and activator of transcription 4
MGI:103062

25 phenotypes from 4 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Stat4^em1(IMPC)Mbp/Stat4^em1(IMPC)Mbp C57BL/6N-Stat4^em1(IMPC)Mbp/MbpMmucd	abnormal kidney morphology	J:211773
	abnormal vitreous body morphology	J:211773
	cataract	J:211773
	cornea opacity	J:211773
	small kidney	J:211773
Stat4^ity14/Stat4^ity14 involves: 129S1/Sv * 129X1/SvJ	decreased circulating interferon-gamma level	J:207092
	decreased interferon-gamma secretion	J:207092
	increased circulating interleukin-12 level	J:207092
	increased susceptibility to bacterial infection	J:207092
	increased susceptibility to bacterial infection induced morbidity/mortality	J:207092
Stat4^ity14/Stat4^tm1Gru involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	increased susceptibility to bacterial infection induced morbidity/mortality	J:207092
Stat4^tm1Gru/Stat4⁺ NOD.129S2-Stat4^tm1Gru	abnormal circulating glucose level	J:90600
Stat4^tm1Gru/Stat4^tm1Gru C.129S2-Stat4^tm1Gru	abnormal CD4-positive T cell differentiation	J:143729
	abnormal kidney physiology	J:84825
	decreased circulating interferon-gamma level	J:90600
	decreased circulating interleukin-2 level	J:90600
Stat4^tm1Gru/Stat4^tm1Gru involves: 129S2/SvPas	abnormal cytokine secretion	J:112600
Stat4^tm1Gru/Stat4^tm1Gru involves: 129S2/SvPas * BALB/c	abnormal lymphocyte physiology	J:34059
	abnormal NK cell physiology	J:34059
	abnormal T cell proliferation	J:34059
	abnormal T-helper 1 physiology	J:34059
	abnormal T-helper 2 physiology	J:34059
	decreased circulating interferon-gamma level	J:163843
	decreased interferon-gamma secretion	J:34059
	increased susceptibility to bacterial infection	J:163843
	increased susceptibility to bacterial infection induced morbidity/mortality	J:163843
Stat4^tm1Gru/Stat4^tm1Gru NOD.129S2-Stat4^tm1Gru	abnormal inflammatory response	J:90600
	abnormal insulin secretion	J:90600
	abnormal pancreatic beta cell morphology	J:90600
	decreased circulating interferon-gamma level	J:90600
	decreased circulating interleukin-2 level	J:90600
	decreased susceptibility to autoimmune diabetes	J:90600
Stat4^tm1Jni/Stat4^tm1Jni involves: 129P2/OlaHsd * C57BL/6	abnormal NK cell physiology	J:79552
	decreased circulating interferon-gamma level	J:79552
	decreased susceptibility to autoimmune diabetes	J:96338
	increased interleukin-4 secretion	J:96338

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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