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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Stat1
signal transducer and activator of transcription 1
MGI:103063
92 phenotypes from 15 alleles in 23 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Stat1fae/Stat1fae
C57BL/6JSfdAnu-Stat1fae/Anu 		abnormal T cell activation J:105311
abnormal T-helper 2 physiology J:105311
increased IgG level J:105311
Stat1m1Anu/Stat1m1Anu
C57BL/6JSfdAnu-Stat1m1Anu 		abnormal response to infection J:104190
Stat1m1Btlr/Stat1m1Btlr
C57BL/6J-Stat1m1Btlr 		abnormal macrophage physiology J:105543
increased susceptibility to Herpesvirales infection J:105543
increased susceptibility to Riboviria infection J:105543
Stat1m2Btlr/Stat1m2Btlr
C57BL/6J-Stat1m2Btlr 		decreased interferon-gamma secretion J:134096
decreased NK cell degranulation J:134096
impaired natural killer cell mediated cytotoxicity J:134096
increased susceptibility to Herpesvirales infection J:134096
Stat1m3Btlr/Stat1m3Btlr
C57BL/6J-Stat1m3Btlr 		impaired natural killer cell mediated cytotoxicity J:254835
Stat1m4Btlr/Stat1m4Btlr
C57BL/6J-Stat1m4Btlr 		abnormal CD8-positive, naive alpha-beta T cell number J:264800
decreased B cell number J:264800
decreased B-1 B cell number J:264800
decreased CD8-positive, alpha-beta T cell number J:264800
decreased NK cell number J:264800
decreased single-positive T cell number J:264800
increased CD4-positive, alpha-beta T cell number J:264800
increased effector memory CD8-positive, alpha-beta T cell number J:264800
increased NK T cell number J:264800
Stat1m5Btlr/Stat1m5Btlr
C57BL/6J-Stat1m5Btlr 		abnormal CD4-positive T cell differentiation J:274938
abnormal CD8-positive, alpha-beta T cell differentiation J:274938
abnormal T cell differentiation J:274938
decreased CD8-positive, naive alpha-beta T cell number J:274938
decreased cytotoxic T cell cytolysis J:274938
increased CD4-positive, alpha-beta T cell number J:274938
increased effector memory CD4-positive, alpha-beta T cell number J:274938
increased effector memory CD8-positive, alpha-beta T cell number J:274938
increased T cell number J:274938
Stat1tm1.2Mmul/Stat1tm1.2Mmul
B6.129P2-Stat1tm1.2Mmul 		no abnormal phenotype detected J:183580
Stat1tm1Dlv/Stat1tm1Dlv
B6.129-Stat1tm1Dlv 		increased susceptibility to Herpesvirales infection J:81243
increased susceptibility to Togaviridae infection J:81243
Stat1tm1Dlv/Stat1tm1Dlv
B6.129S-Stat1tm1Dlv 		abnormal NK cell physiology J:79552
impaired natural killer cell mediated cytotoxicity J:79552
increased circulating interferon-gamma level J:79552
increased circulating interleukin-12b level J:79552
increased mammary adenocarcinoma incidence J:216040
Stat1tm1Dlv/Stat1tm1Dlv
either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1) 		abnormal intestine morphology J:31325
abnormal leukocyte physiology J:31325
decreased body size J:31325
increased susceptibility to Coronaviridae infection J:31325
increased susceptibility to Riboviria infection J:31325
lethality at weaning, complete penetrance J:31325
multifocal hepatic necrosis J:31325
Stat1tm1Dlv/Stat1tm1Dlv
involves: 129S/SvEv 		abnormal MHC II cell surface expression on macrophages J:130622
decreased level of surface class I molecules J:130622
decreased susceptibility to endotoxin shock J:130622
normal immune system phenotype J:99728
increased circulating interferon-gamma level J:130622
increased susceptibility to bacterial infection J:130622
increased susceptibility to Riboviria infection J:130622
normal vision/eye phenotype J:88422
Stat1tm1Mam/Stat1tm1Mam
Tg(MMTV-cre)#Mam/0
involves: 129S/SvEv * FVB 		normal integument phenotype J:169262
Stat1tm1Mam/Stat1tm1Mam
Tg(Wap-cre)11738Mam/0
involves: 129S/SvEv * C57BL/6 * SJL 		normal integument phenotype J:169262
Stat1tm1Rds/Stat1tm1Rds
129S6/SvEv-Stat1tm1Rds/Tac 		abnormal macrophage physiology J:136368
abnormal nitric oxide homeostasis J:122801
abnormal osteoclast differentiation J:131353
abnormal redox activity J:122801
bronchiolitis J:286237
decreased circulating interferon-gamma level J:122801
decreased hepatocyte apoptosis J:122801
decreased interleukin-1 beta secretion J:136368
decreased susceptibility to neuronal excitotoxicity J:116659
increased cardiomyocyte apoptosis J:120449
increased mammary adenocarcinoma incidence J:216040
increased myocardial infarct size J:120449
increased NK T cell number J:122801
increased susceptibility to Coronaviridae infection J:286237
increased susceptibility to Coronaviridae infection induced morbidity/mortality J:286237
lung inflammation J:286237
peritoneal inflammation J:286237
pleuritis J:286237
pulmonary edema J:286237
pulmonary necrosis J:286237
Stat1tm1Rds/Stat1tm1Rds
B6.129-Stat1tm1Rds 		abnormal osteoblast differentiation J:84894
abnormal tibia morphology J:84894
increased bone mass J:84894
increased bone resorption J:84894
increased compact bone thickness J:84894
increased compact bone volume J:84894
increased osteoclast cell number J:84894
increased trabecular bone volume J:84894
Stat1tm1Rds/Stat1tm1Rds
C3.129-Stat1tm1Rds 		tumor regression J:108303
Stat1tm1Rds/Stat1tm1Rds
either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) 		abnormal cell physiology J:31326
increased susceptibility to bacterial infection J:31326
increased susceptibility to Riboviria infection J:31326
Stat1tm1Rds/Stat1tm1Rds
involves: 129 		abnormal cell cycle J:109408
abnormal common myeloid progenitor cell morphology J:109408
abnormal cornea morphology J:62316
decreased sensitivity to induced cell death J:62316
increased susceptibility to Herpesvirales infection J:81243
increased susceptibility to Riboviria infection J:66564
increased susceptibility to Togaviridae infection J:81243
Stat1tm1Tdec/Stat1tm1Tdec
involves: 129P2/OlaHsd * BALB/c 		abnormal macrophage physiology J:130622
abnormal MHC II cell surface expression on macrophages J:130622
decreased susceptibility to endotoxin shock J:130622
increased susceptibility to bacterial infection J:130622
increased susceptibility to Riboviria infection J:130622
Stat1tm1Uvin/Stat1tm1Uvin
involves: 129 * C57BL/6 		increased macrophage nitric oxide production J:174863
Stat1tm2.1Uvin/Stat1tm2.1Uvin
B6.129P2-Stat1tm2.1Uvin 		decreased susceptibility to endotoxin shock J:209388
normal immune system phenotype J:209388
increased susceptibility to bacterial infection J:209388
increased susceptibility to bacterial infection induced morbidity/mortality J:209388
Stat1tm2b(EUCOMM)Wtsi/Stat1tm2b(EUCOMM)Wtsi
C57BL/6N-Stat1tm2b(EUCOMM)Wtsi/Orl 		abnormal gait J:211773
decreased bone mineral content J:211773
decreased circulating alkaline phosphatase level J:211773
decreased lymphocyte cell number J:211773
decreased mean corpuscular hemoglobin J:211773
decreased mean corpuscular volume J:211773
enlarged lymph nodes J:211773
impaired righting response J:211773
increased basophil cell number J:211773
increased eosinophil cell number J:211773
increased large unstained cell number J:211773
increased leukocyte cell number J:211773
increased lymphocyte cell number J:211773
increased monocyte cell number J:211773
increased neutrophil cell number J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory