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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		H2-Ab1
histocompatibility 2, class II antigen A, beta 1
MGI:103070
67 phenotypes from 11 alleles in 16 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
H2-Ab1b-tm1.1Jssh/H2-Ab1b-tm1.1Jssh
C57BL/6-H2-Ab1b-tm1.1Jssh 		abnormal dendritic cell antigen presentation J:201198
abnormal T cell differentiation J:201198
decreased regulatory T cell number J:201198
H2-Ab1b-tm1.1Koni/H2-Ab1b-tm1.1Koni
Tg(Tek-cre)12Flv/0
involves: 129X1/SvJ * C3H * C57BL/6 * C57BL/6J 		preweaning lethality, incomplete penetrance J:131774
H2-Ab1b-tm1.1Sish/H2-Ab1b-tm1.1Sish
involves: 129S1/Sv * 129X1/SvJ 		abnormal dendritic cell physiology J:157516
decreased interleukin-12 secretion J:157516
decreased tumor necrosis factor secretion J:157516
H2-Ab1b-tm1Doi/H2-Ab1+
involves: 129S2/SvPas * C57BL/6 * NOD/Lt 		insulitis J:93557
H2-Ab1b-tm1Doi/H2-Ab1b-tm1Doi
involves: 129S2/SvPas 		abnormal neuron proliferation J:170591
H2-Ab1b-tm1Doi/H2-Ab1b-tm1Doi
involves: 129S2/SvPas * C57BL/6 		abnormal B cell physiology J:65736
abnormal CD4-positive, alpha beta T cell morphology J:65736
abnormal CD4-positive, alpha-beta T cell physiology J:65736
abnormal cytokine secretion J:64283
abnormal immune system cell morphology J:65736
abnormal immune system morphology J:65736
abnormal immune system organ morphology J:65736
abnormal immune system physiology J:65736
abnormal lymph node cell ratio J:65736
abnormal spleen B cell follicle morphology J:65736
abnormal spleen marginal zone morphology J:65736
abnormal spleen morphology J:65736
abnormal spleen periarteriolar lymphoid sheath morphology J:65736
abnormal T cell physiology J:65736
absent spleen germinal center J:65736
decreased CD4-positive, alpha-beta T cell number J:51885, J:65736
decreased IgG1 level J:65736
decreased susceptibility to parasitic infection J:64283
increased CD4-positive, alpha-beta T cell number J:64283
increased CD8-positive, alpha-beta T cell number J:64283, J:65736
increased susceptibility to parasitic infection J:64283
postnatal growth retardation J:65736
reduced fertility J:65736
H2-Ab1b-tm1Doi/H2-Ab1b-tm1Doi
involves: 129S2/SvPas * C57BL/6 * NOD/Lt 		insulitis J:93557
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
B6.129S2-H2-Ab1b-tm1Gru 		abnormal B cell physiology J:91341
abnormal lymphocyte physiology J:91341
decreased CD4-positive, alpha-beta T cell number J:91341
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
involves: 129S2/SvPas 		abnormal artery development J:134875
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
involves: 129S2/SvPas * C57BL/6 		abnormal level of surface class II molecules J:67941
decreased CD4-positive, alpha-beta T cell number J:67941
decreased IgG1 level J:67941
decreased IgM level J:67941
decreased single-positive T cell number J:67941
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
involves: 129S2/SvPas * C57BL/6J 		abnormal humoral immune response J:74418
abnormal response to transplant J:91742
decreased CD4-positive, alpha-beta T cell number J:74418
decreased IgG level J:74418
increased CD8-positive, alpha-beta T cell number J:74418
increased IgM level J:74418
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
NOD.129S2-H2-Ab1b-tm1Gru 		normal cardiovascular system phenotype J:86540
normal immune system phenotype J:86540
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(Ab1TL)1Gru/0
B6.Cg-H2-Ab1b-tm1Gru Tg(Ab1TL)1Gru 		abnormal CD4-positive T cell differentiation J:91341
abnormal macrophage antigen presentation J:91341
abnormal professional antigen presenting cell physiology J:91341
H2-Ab1b-tm1Hpl/H2-Ab1+
involves: 129S4/SvJae 		no abnormal phenotype detected J:78940
H2-Ab1b-tm1Koni/H2-Ab1b-tm1.1Koni
Tg(Tek-cre)12Flv/0
involves: 129X1/SvJ * C3H * C57BL/6 * C57BL/6J 		abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology J:131774
abnormal T cell activation J:131774
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:131774
decreased level of surface class II molecules J:131774
normal immune system phenotype J:131774
increased CD4-positive, alpha-beta T cell number J:131774
H2-Ab1b-tm1Koni/H2-Ab1b-tm1Koni
involves: 129X1/SvJ * C57BL/6J 		no abnormal phenotype detected J:75115
H2-Ab1b-tm1Wug/H2-Ab1b-tm1Wug
involves: C57BL/6 		abnormal B cell physiology J:204951
abnormal dendritic cell physiology J:204951
absent CD4-positive, alpha-beta T cells J:204951
decreased susceptibility to experimental autoimmune encephalomyelitis J:204951
H2-Ab1b-tm1Wug/H2-Ab1b-tm1Wug
Cd19tm1(cre)Cgn/Cd19+
involves: 129S2/SvPas * C57BL/6 		abnormal B cell physiology J:204951
abnormal dendritic cell physiology J:204951
decreased susceptibility to experimental autoimmune encephalomyelitis J:204951
normal immune system phenotype J:204951
H2-Ab1bm12/H2-Ab1bm12
B6(C)-H2-Ab1bm12/KhEgJ 		abnormal level of surface class II molecules J:100194
abnormal T cell physiology J:100123
decreased susceptibility to autoimmune disorder J:100123
decreased susceptibility to experimental autoimmune myasthenia gravis J:100213
decreased susceptibility to parasitic infection J:48242
H2-Ab1bm12/H2-Ab1bm12
NZB.B6(C)-H2-Ab1bm12 		abnormal immunoglobulin level J:104189
abnormal level of surface class II molecules J:104189
abnormal response/metabolism to endogenous compounds J:104189
autoimmune response J:4554
decreased CD8-positive, alpha-beta T cell number J:4554
hemolytic anemia J:4554
increased anti-double stranded DNA antibody level J:104189
increased anti-erythrocyte antigen antibody level J:4554
increased anti-single stranded DNA antibody level J:104189
increased B cell number J:104189
increased CD4-positive, alpha-beta T cell number J:4554
increased double-negative T cell number J:4554
increased urine protein level J:104189
premature death J:104189
H2-Ab1g7-em1Ygch/H2-Ab1g7-em1Ygch
NOD/ShiLtJ-H2-Ab1g7-em1Ygch 		decreased CD4-positive, alpha-beta T cell number J:101977
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11/12/2024
MGI 6.24 		The Jackson Laboratory