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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Wee1
WEE 1 homolog 1 (S. pombe)
MGI:103075
15 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tg(CAG-cre/Esr1*)5Amc/0
Wee1tm1Cxd/Wee1tm1Cxd
involves: 129S6/SvEvTac * C57BL/6 * CBA 		abnormal cell cycle checkpoint function J:228492
abnormal cell morphology J:228492
increased apoptosis J:228492
Wee1Tg(Tyr)2416BOve/Wee1Tg(Tyr)2416BOve
FVB/N-Wee1Tg(Tyr)2416BOve 		embryonic lethality between implantation and somite formation J:175597
Wee1tm1.1Cxd/Wee1tm1.1Cxd
involves: 129S6/SvEvTac * FVB/N 		abnormal cell cycle checkpoint function J:228492
decreased embryonic epiblast cell proliferation J:228492
embryonic lethality before implantation, incomplete penetrance J:228492
embryonic lethality between implantation and somite formation, complete penetrance J:228492
increased cellular sensitivity to gamma-irradiation J:228492
increased embryonic epiblast cell apoptosis J:228492
Wee1tm1b(EUCOMM)Wtsi/Wee1+
C57BL/6N-Wee1tm1b(EUCOMM)Wtsi/Tcp 		decreased mean corpuscular hemoglobin J:211773
decreased mean corpuscular hemoglobin concentration J:211773
increased circulating alanine transaminase level J:211773
Wee1tm1b(EUCOMM)Wtsi/Wee1tm1b(EUCOMM)Wtsi
C57BL/6N-Wee1tm1b(EUCOMM)Wtsi/Tcp 		embryonic lethality prior to organogenesis J:211773
embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory