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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Vdr
vitamin D (1,25-dihydroxyvitamin D3) receptor
MGI:103076
161 phenotypes from 11 alleles in 17 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tg(Col1a1-cre)1Kry/0
Vdrtm2Ska/Vdrtm2Ska
involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj * FVB/N 		abnormal osteoclast differentiation J:196471
decreased bone resorption J:196471
decreased osteoclast cell number J:196471
normal homeostasis/metabolism phenotype J:196471
increased bone mass J:196471
increased bone mineral density J:196471
increased trabecular bone volume J:196471
normal skeleton phenotype J:196471
Vdrem1(IMPC)Hmgu/Vdrem1(IMPC)Hmgu
C57BL/6NCrl-Vdrem1(IMPC)Hmgu/Ieg 		abnormal bone structure J:211773
abnormal coat/ hair morphology J:211773
abnormal coat/hair pigmentation J:211773
abnormal gait J:211773
abnormal head morphology J:211773
abnormal locomotor behavior J:211773
decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased grip strength J:211773
decreased locomotor activity J:211773
decreased startle reflex J:211773
decreased vertical activity J:211773
increased lean body mass J:211773
increased neutrophil cell number J:211773
increased prepulse inhibition J:211773
short tibia J:211773
tremors J:211773
Vdrtm1.1Gcm/Vdrtm1.1Gcm
involves: 129 * BALB/c * C57BL/6 * Swiss 		abnormal vitamin D level J:72578
decreased body weight J:72578
decreased bone mineral density J:72578
decreased circulating calcium level J:72578
decreased intestinal calcium absorption J:72578
increased circulating parathyroid hormone level J:72578
rickets J:72578
Vdrtm1.1Gcm/Vdrtm1.1Gcm
involves: 129S1/Sv * 129X1/SvJ 		abnormal bone mineralization J:111515
abnormal urine homeostasis J:111515
abnormal vitamin D level J:111515
decreased bone mineral density J:111515
decreased circulating calcium level J:111515
decreased uterus weight J:111515
rickets J:111515
Vdrtm1.1Sgcg/Vdrtm1.2Sgcg
Myl2tm1(cre)Krc/Myl2+
involves: 129 * C57BL/6 * CBA * SJL 		abnormal heart ventricle morphology J:189471
cardiac hypertrophy J:189471
normal cardiovascular system phenotype J:189471
decreased mean systemic arterial blood pressure J:189471
decreased systemic arterial diastolic blood pressure J:189471
normal endocrine/exocrine gland phenotype J:189471
normal homeostasis/metabolism phenotype J:189471
increased circulating atrial natriuretic factor J:189471
increased heart left ventricle weight J:189471
increased myocardial fiber size J:189471
thick interventricular septum J:189471
thick ventricular wall J:189471
Vdrtm1.2Sgcg/Vdrtm1.2Sgcg
involves: 129 * C57BL/6 * CBA * SJL 		alopecia J:189471
decreased body weight J:189471
decreased circulating calcium level J:189471
increased activity of parathyroid J:189471
increased circulating atrial natriuretic factor J:189471
increased heart left ventricle weight J:189471
Vdrtm1Gcm/Vdrtm1Gcm
Tg(Col2a1-cre)1Bhr/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal mineral homeostasis J:117377
abnormal trabecular bone morphology J:117377
abnormal vitamin D level J:117377
decreased angiogenesis J:117377
decreased osteoclast cell number J:117377
delayed endochondral bone ossification J:117377
increased circulating phosphate level J:117377
Vdrtm1Mbd/Vdr+
involves: 129S4/SvJae 		increased bone mass J:196471
increased bone mineral density J:196471
increased trabecular bone volume J:196471
Vdrtm1Mbd/Vdr+
involves: 129S4/SvJae * C57BL/6 		normal cardiovascular system phenotype J:120353
increased heart weight J:120353
Vdrtm1Mbd/Vdrtm1Mbd
involves: 129S4/SvJae 		abnormal bone mineralization J:42815
abnormal tibia morphology J:42815
alopecia J:42815
decreased body weight J:42815
decreased circulating calcium level J:42815, J:78067
dermal cyst J:42815
dilated hair follicle J:42815
disorganized long bone epiphyseal plate J:42815
enlarged parathyroid gland J:42815
hypertension J:78067
increased circulating angiotensin II level J:78067
increased circulating angiotensinogen level J:78067
increased circulating parathyroid hormone level J:42815, J:63291, J:78067
increased circulating renin level J:78067
increased fluid intake J:78067
increased heart weight J:78067
increased renin activity J:78067
increased systemic arterial diastolic blood pressure J:78067
increased systemic arterial systolic blood pressure J:78067
increased urine potassium level J:78067
increased urine sodium level J:78067
increased width of hypertrophic chondrocyte zone J:42815
polyuria J:78067
postnatal growth retardation J:42815
rickets J:42815
short femur J:42815
short tibia J:42815
Vdrtm1Mbd/Vdrtm1Mbd
involves: 129S4/SvJae * C57BL/6 		abnormal enzyme/coenzyme activity J:120340
abnormal interleukin level J:107077
abnormal intestinal epithelium morphology J:130511
abnormal intestinal mucosa morphology J:130511
abnormal large intestine crypts of Lieberkuhn morphology J:130511
abnormal myocardial fiber physiology J:131143
abnormal renin activity J:120353
abnormal tumor necrosis factor level J:107077
cardiac fibrosis J:120340
cardiac hypertrophy J:120340
normal cardiovascular system phenotype J:120353
decreased systemic arterial systolic blood pressure J:120353
normal immune system phenotype J:107077
increased heart weight J:120340, J:120353
increased susceptibility to induced colitis J:130511
increased susceptibility to xenobiotic induced morbidity/mortality J:130511
increased thymus weight J:107077
intestinal inflammation J:107077
intestinal ulcer J:130511
thymus hyperplasia J:107077
weight loss J:130511
Vdrtm1Mbd/Vdrtm1Mbd
involves: 129S4/SvJae * C57BL/6J 		abnormal chondrocyte morphology J:99866
abnormal mineral homeostasis J:99866
decreased circulating phosphate level J:99866
increased width of hypertrophic chondrocyte zone J:99866
rickets J:99866
Vdrtm1Rge/Vdrtm1Rge
B6.129-Vdrtm1Rge 		decreased bone mineral density J:121006
decreased circulating phosphate level J:121006
epidermal cyst J:121006
increased circulating alkaline phosphatase level J:121006
increased circulating parathyroid hormone level J:121006
Vdrtm1Rge/Vdrtm1Rge
involves: 129S1/Sv * 129X1/SvJ 		abnormal response to vitamins J:77748
abnormal vitamin D level J:77748
alopecia J:77748
decreased circulating calcium level J:77748
increased activity of parathyroid J:77748
increased circulating parathyroid hormone level J:77748
increased urine calcium level J:77748
rickets J:77748
slow postnatal weight gain J:77748
Vdrtm1Rge/Vdrtm1Rge
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal macrophage physiology J:134827
abnormal nitric oxide homeostasis J:134827
decreased susceptibility to parasitic infection J:134827
Vdrtm1Ska/Vdrtm1Ska
involves: 129 * C57BL/6NCrlj * CBA/JNCrlj 		abnormal locomotor activation J:95324
abnormal response to new environment J:95324
abnormal startle reflex J:95324
alopecia J:95324
decreased body size J:95324
decreased locomotor activity J:95324
decreased prepulse inhibition J:95324
decreased vertical activity J:95324
impaired coordination J:95324
short stride length J:95324
Vdrtm1Ska/Vdrtm1Ska
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal blood homeostasis J:112519
abnormal bone mineralization J:112519
abnormal bone ossification J:42054
abnormal bone structure J:42054
abnormal coat/ hair morphology J:110729
abnormal colon morphology J:71459
abnormal epidermis stratum granulosum morphology J:110729
abnormal estrous cycle J:83237
abnormal fat-soluble vitamin level J:71459, J:112519
abnormal female reproductive system morphology J:42054
abnormal fertility/fecundity J:42054
abnormal fibula morphology J:42054
abnormal gametogenesis J:83237
abnormal large intestine crypts of Lieberkuhn morphology J:71459
abnormal limb bone morphology J:42054
abnormal long bone hypertrophic chondrocyte zone J:42054
abnormal long bone metaphysis morphology J:42054
abnormal macrophage chemotaxis J:112519
abnormal male reproductive system morphology J:83237
abnormal skin development J:110729
abnormal spermatogenesis J:83237
abnormal tibia morphology J:42054
abnormal trabecular bone morphology J:42054
abnormal vitamin D level J:42054
absent mature ovarian follicles J:42054
alopecia J:42054, J:67149, J:110729
asthenozoospermia J:83237
decreased body weight J:42054, J:72578
decreased bone mineral density J:42054, J:72578
decreased circulating calcium level J:42054, J:69822, J:71459, J:72578, J:83237, J:112519
decreased circulating phosphate level J:42054
decreased compact bone thickness J:42054
decreased hair follicle cell proliferation J:110729
decreased intestinal calcium absorption J:72578
decreased splenocyte proliferation J:112519
decreased susceptibility to autoimmune diabetes J:112519
dermal cyst J:110729
dermatitis J:111828
dilated hair follicle J:110729
dilated seminiferous tubule J:83237
female infertility J:42054, J:69822
flat face J:42054
increased circulating alkaline phosphatase level J:42054
increased circulating follicle stimulating hormone level J:83237
increased circulating luteinizing hormone level J:83237
increased long bone epiphyseal plate size J:42054
increased osteoblast cell number J:42054
increased testis weight J:83237
normal integument phenotype J:111828
male infertility J:42054, J:69822
oligozoospermia J:83237
postnatal growth retardation J:42054, J:110729
premature death J:42054, J:69822
reduced female fertility J:69822
reduced male fertility J:69822
rickets J:72578, J:110729
short snout J:42054
sparse vibrissae J:42054
uterus hypoplasia J:42054
Vdrtm1Ska/Vdrtm1Ska
NOD.Cg-Vdrtm1Ska/CmatJ 		abnormal chemokine secretion J:127787
abnormal dendritic cell differentiation J:127787
abnormal glucose tolerance J:127787
abnormal interleukin-1 secretion J:127787
abnormal T cell number J:127787
alopecia J:127787
decreased bone mineral density J:127787
decreased circulating calcium level J:127787
decreased interleukin-6 secretion J:127787
decreased regulatory T cell number J:127787
increased long bone epiphyseal plate size J:127787
increased susceptibility to autoimmune diabetes J:127787
postnatal growth retardation J:127787
Vdrtm1Tyam/Vdrtm1Tyam
involves: C57BL/6 * CBA 		abnormal femur morphology J:101456
abnormal vitamin D level J:101456
decreased body weight J:101456
decreased bone mineral density of femur J:101456
decreased circulating calcium level J:101456
decreased circulating phosphate level J:101456
increased circulating parathyroid hormone level J:101456
increased width of hypertrophic chondrocyte zone J:101456
postnatal growth retardation J:101456
short femur J:101456
Vdrtm2.1Ska/Vdr+
involves: C57BL/6 * CBA/JNCrlj * SJL 		increased bone mass J:196471
increased bone mineral density J:196471
increased trabecular bone volume J:196471
Vdrtm2.1Ska/Vdrtm2.1Ska
involves: C57BL/6 * CBA/JNCrlj * SJL 		abnormal bone ossification J:196471
abnormal vitamin D level J:196471
alopecia J:196471
decreased circulating calcium level J:196471
decreased circulating phosphate level J:196471
disorganized long bone epiphyseal plate J:196471
increased activity of parathyroid J:196471
increased osteoid volume J:196471
postnatal growth retardation J:196471
premature death J:196471
weight loss J:196471
Vdrtm2Ska/Vdrtm2Ska
involves: C57BL/6NCrlj * CBA/JNCrlj 		ear inflammation J:111828
mixed cellular infiltration to dermis J:111828
Vdrtm2Ska/Vdrtm2Ska
Tg(KRT14-cre)1Ipc/0
involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL 		normal integument phenotype J:111828
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory