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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Vdr
vitamin D (1,25-dihydroxyvitamin D3) receptor
MGI:103076
36 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cyp24a1tm1Star/Cyp24a1tm1Star
Vdrtm1Mbd/Vdrtm1Mbd
involves: 129S4/SvJae 		normal skeleton phenotype J:63457
Fgf23tm1Blan/Fgf23tm1Blan
Vdrtm1Rge/Vdrtm1Rge
involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6 		epidermal cyst J:121006
normal homeostasis/metabolism phenotype J:121006
increased circulating alkaline phosphatase level J:121006
increased circulating parathyroid hormone level J:121006
Il10tm1Cgn/Il10tm1Cgn
Vdrtm1Mbd/Vdrtm1Mbd
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		abnormal CD4-positive, alpha-beta T cell physiology J:107077
abnormal cytokine level J:107077
abnormal lymph node cell ratio J:107077
abnormal splenic cell ratio J:107077
abnormal thymus corticomedullary boundary morphology J:107077
abnormal thymus involution J:107077
absent spleen white pulp J:107077
anemia J:107077
colitis J:107077
decreased lymphocyte cell number J:107077
decreased T cell proliferation J:107077
enlarged mesenteric lymph nodes J:107077
enlarged spleen J:107077
increased macrophage cell number J:107077
increased neutrophil cell number J:107077
increased spleen red pulp amount J:107077
increased T cell apoptosis J:107077
intestinal inflammation J:107077
rectal prolapse J:107077
thymus hypoplasia J:107077
Tg(VDR*L233S,luc)T807Pike/0
Vdrtm1Mbd/Vdrtm1Mbd
involves: 129S4/SvJae * C57BL/6 		abnormal epiphyseal plate morphology J:218709
abnormal skeleton physiology J:218709
decreased bone mineral density J:218709
decreased bone mineral density of femur J:218709
decreased circulating calcium level J:218709
decreased circulating phosphate level J:218709
increased activity of parathyroid J:218709
increased circulating parathyroid hormone level J:218709
normal integument phenotype J:218709
parathyroid gland hyperplasia J:218709
rickets J:218709
short tibia J:218709
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory